Sugar water gel liquid emboliaztion agent for hemangioma cure and preparation method thereof

Abstract

The invention discloses a sugar water gel liquid emboliaztion agent for hemangioma cure. The sugar water gel liquid emboliaztion agent for hemangioma cure comprises that an effective embolism component is natural polysaccharide gellan gum, a developing component is metal tantalum powder and a solvent component is organic solvent dimethyl sulfoxide. The natural polysaccharide gellan gum is processed by oxidation of sugar chain cutting technology. The invention further discloses a preparation method of the sugar water gel liquid emboliaztion agent. According to the sugar water gel liquid emboliaztion agent for hemangioma cure and the preparation method of the sugar water gel liquid emboliaztion agent, an embolism condition is groped, the technical problems that the effective embolism and inducing thrombosis are formed in a tumor cavity range and a far-end drifting is prevented under the condition that auxiliary materials of sacculus, a support frame and the like are not needed are solved. The natural polysaccharide gellan gum in the embolism component plays a role in good biology compatibility and promoting the forming of the thrombosis. Requirements that the ideal liquid emboliaztion agent should be provided are met, thus a good embolism effect and high safety are achieved.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and relates to a polysaccharide hydrogel liquid embolic agent for treating hemangioma and a preparation method thereof. Background technique [0002] Hemangiomas include aneurysms, venous aneurysms, and lymphangiomas, which can occur in multiple body parts such as the brain, liver, and lower extremities. Take intracranial aneurysm, a common disease in neurosurgery, as an example. Subarachnoid hemorrhage can occur after aneurysm rupture. The mortality rate of aneurysm rupture is about 30-40% for the first time, and the mortality rate of re-rupture can reach 60%. The only traditional treatment is to clip the aneurysm with a surgical craniotomy. However, the disadvantages of surgical craniotomy are very obvious: 1. The proportion of patients who can accept surgery is limited: or those who are not suitable due to age or health, or those with multiple SAH and HH grades, or those with vaso...

AI Technical Summary

Problems solved by technology

The application disadvantages of these materials are also obvious: for example, NBCA is adhesive, it is easy to make the microcatheter and the blood vessel adhere, and the embolization lesion amount is small each time; the traditional CAP solution does not solve the problem of controlling the distal drift in the tumor cavity. technical challenge

At present, the most mature liquid embolic agent ONYX is based on vinylidene alcohol heteromolecular polymer (EVOH), which also has the problem of being unable to control the distal drift in the tumor cavity. Among the imported products that have been clinically used, it uses The solution is to place a occlusion balloon at the parent artery at the neck of the aneurysm, which not only increases the cost, but also introduces new foreign bodies into the body

In addition, all these materials use artificially synthesized polymers, some of which are commonly used chemical raw materials, and their biocompatibility and bioabsorbability are not very clear, which greatly limits their use in the human body, especially in contact with blood vessels and Intracranial use of liquid embolic agents

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