Suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process

A technology of iodized oil and suspension, which is applied in the field of medicine and preparation of magnetic microspheres to treat tumors, and can solve the problems of difficulty in selectively entering the embolization target area, insufficient thorough and long-lasting embolization, etc.

Inactive Publication Date: 2006-12-06
KUNMING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

with Fe 3 o 4 As a permanent peripheral embolic agent, microparticles have been proved to have a good embolism effect through basic experiments and clinical research, and Fe 3 o 4 While blocking the blood flow, the magnetic field of the microparticles can still inhibit the tumor cells to a certain extent; however, it is difficult to selectively enter the embolization target area.
As a pro-tumor carrier, lipiodol can carry anticancer drugs selectively into tumor tissue, and has good orientation and certain embolization effect. The effect is not thorough and long-lasting

Method used

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  • Suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process
  • Suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process
  • Suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process

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Embodiment Construction

[0081] The embodiment consistent with the subject matter of the technical solution of the present invention has the following modes:

[0082] 1. Embolization of rabbit renal artery.

[0083] Take Fe3O4 particles with a particle size of 250μm and mix them with lipiodol at 100mg: 1ml, and inject them in vitro with a 3-6F catheter to observe the passage of the suspension; 15 New Zealand white rabbits with qualified certificates are used for group control experiments. , using rabbit femoral artery puncture, intubation to the right rabbit renal artery, the experimental group (10) was embolized with STML with a particle size of 250 μm, and the control group (5) was embolized with iodized oil. The animals in the experimental group underwent angiography at 3 days, 1 week, 2 weeks, 4 weeks, 6 weeks, and 8 weeks after the operation; the animals in the control group underwent angiography to observe the embolism at 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after the operation, respect...

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Abstract

The invention relates to a suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process, wherein the suspension wherein the suspension is prepared by fully mixing 50um-300um Fe3O4 particles with non-limited specification and iodized oil by the proportion of 85-110mg : 1ml.

Description

Technical field [0001] The invention belongs to a medicine for treating tumors with magnetic microspheres and a preparation method, and particularly relates to a magnetic microsphere suspension for treating liver and kidney tumors through arterial guided embolization and a preparation method. Background technique [0002] The onset of liver cancer is insidious, and most patients are already in the middle or late stage at the time of diagnosis. Combined with the background of liver disease and the high recurrence rate of surgery, the surgical resection rate of liver cancer is low. Therefore, most patients with liver cancer are treated non-surgically. At present, hepatic artery embolization has become the main method for the treatment of middle and advanced liver cancer among the non-surgical therapy with definite curative effect. However, while embolizing tumor blood vessels, common embolic agents also cause embolization of some normal blood vesse...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/26A61K47/02A61K45/08A61K9/107A61P35/00
Inventor 袁曙光阎东顾亚律郭立王家平程新宝李迎春普成荣韩正林
Owner KUNMING MEDICAL UNIVERSITY
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