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Temperature controllable heat therapeutic embolizing sponge powder an its preparation process

A technology for embolizing sponges and granules, used in powder delivery, drug combination, anti-tumor drugs, etc., can solve the problems of inability to achieve chemoembolization, difficult to maintain hyperthermia, and inability to achieve complete embolization, and achieve strong vascular wall adhesion. , Improve the effect of embolization

Active Publication Date: 2008-04-30
杭州艾力康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned methods all have obvious deficiencies: with Fe 3 o 4 Or the drug-loaded magnetic microspheres prepared by reduced iron powder as a magnetic material are difficult to solve the problem of drug loading of chemotherapy drugs, and the drug loaded on the microspheres is not enough to maintain the drug concentration at the tumor site for a long time; at the same time, the aggregation guided by an external magnetic field cannot achieve complete embolization , failing to achieve the dual purpose of chemoembolization
The hyperthermia method of implanting magnets is itself traumatic, and in order to make the hyperthermia have no blind spots, about 150 magnets need to be implanted for a 5cm×5cm×5cm tumor; It is not possible to adjust its distribution
Encapsulated ferrofluid is currently a relatively well-developed targeted hyperthermia preparation, but ferrofluid easily enters the body circulation from the tumor site and is finally excreted through the kidneys, making it difficult to maintain the effect of hyperthermia
Moreover, hyperthermia alone is likely to cause thermal tolerance of tumor tissue, thereby reducing the effect of hyperthermia.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] ——Dissolve 5 grams of polyvinyl alcohol in 200ml of distilled water in a water bath at 60°C, at 600-1500r·min -1Adding 2g of manganese-zinc ferrite material with a particle size of less than 0.5 microns and a Curie temperature of 40-65°C under stirring conditions to form a solution containing magnetic polymers;

[0036] ——Add appropriate amount of dilute sulfuric acid and stir to make the mixture even;

[0037] ——at 600-1500r·min -1 Add 20ml of 3.7% (g / g) formaldehyde solution under stirring condition; continue stirring until solidification is formed;

[0038] ——Wash the cured product in ethanol;

[0039] ——Treat the cured product at -25°C for more than 0.5 hours;

[0040] —— Use mechanical crushing equipment to crush the cured product to the required particle size range, 50-2000 microns, under low temperature conditions;

[0041] ——put the obtained hyperthermia microspheres in a shaker, and shake for 24 hours;

[0042] ——pass through a 400-mesh sieve in ethanol so...

Embodiment 2

[0047] ——Dissolve 20 grams of gelatin in 250ml of distilled water in a water bath at 45°C, at 600-1500r·min -1 Adding 10 g of manganese-zinc ferrite material with a particle size of less than 0.5 microns and a Curie temperature of 40-65° C. under stirring conditions to form a solution containing magnetic polymers;

[0048] ——at 600-1500r·min -1 Add 20ml of 3.7% (g / g) formaldehyde solution under stirring condition; continue stirring until solidification is formed;

[0049] ——Wash the cured product in ethanol;

[0050] ——Treat the cured product at -25°C for more than 0.5 hours;

[0051] —— Use mechanical crushing equipment to crush the cured product to the required particle size range, 50-2000 microns, under low temperature conditions;

[0052] ——put the obtained hyperthermia microspheres in a shaker, and shake for 24 hours;

[0053] ——pass through a 400-mesh sieve in ethanol solution, and use the pharmacopoeia double sieving method for preliminary sieving;

[0054] ——Colle...

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PUM

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Abstract

The invention relates to temperature controlled thermotherapy embolism sponge particles, which comprise macromolecular material and magnetic responding particles contained therein, the magnetic responding particles made of alloy material having a Curie temperature of 40-65 deg. C are dispersed in a cross-linked network formed by high polymers, the thermotherapy embolism sponge particles have grain diameter of 50-2000um, the water absorption rate is no less than 5 times of the amount of the particles, the magnetic responding particles account to 0.5-45 wt% of the total embolism sponge particles. The invention also discloses the process for preparing the embolism sponge particles.

Description

technical field [0001] The invention relates to thermotherapy embolization sponge particles and a preparation method thereof, in particular to temperature-controllable thermotherapy embolization sponge particles and a preparation method thereof. Background technique [0002] According to the statistics of "Top Ten Disease Death Rates and Causes of Death in Some Cities and Counties in 2003" in "Summary of Health Statistics in China in 2004", the mortality rate of malignant tumors in China in 2003 was 134.54 / 100,000, which was significantly higher than that in the Cerebrovascular disease ranks second in the mortality rate (105.40 / 100,000). Malignant tumors have become the biggest killer threatening the life and health of our people. General conventional treatment: surgical resection, systemic chemotherapy, radiotherapy, etc., the treatment effect is poor, and it is easy to relapse. [0003] The discovery and application of arterial embolization brought about a great leap for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61P35/00
Inventor 严文伟郑隆泗
Owner 杭州艾力康医药科技有限公司
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