A drug-loadable microsphere and its preparation method

Abstract

The invention discloses a novel drug-loadable microsphere and a preparation method thereof. The preparation method is to pre-mix polyvinyl alcohol aqueous solution and hydroxyapatite particles, then add concentrated hydrochloric acid as a catalyst, and then add a cross-linking agent pentadiene Aldehyde is obtained reaction liquid, after pre-reaction 3 seconds-30 seconds, pre-reaction liquid is added dropwise in the mixed oil phase that comprises liquid paraffin and sorbitan fatty acid ester before pre-reaction liquid condenses, at 50 ℃-60 Stirring and reacting in an oil bath at ℃ for at least 3 hours, and then filtering, washing and drying the reacted mixture to obtain drug-loading microspheres. The method of the present invention is beneficial to mass production, and the drug-loadable microspheres prepared by the method have higher drug-loading capacity and encapsulation efficiency, and the slow-release effect is good, and the hydroxyapatite particles are embedded after the polymerization reaction In polyvinyl alcohol, the drug-loaded microspheres have a certain developing function.

Description

technical field [0001] The invention relates to a drug-loadable microsphere and a preparation method thereof. Background technique [0002] Microspheres can be used as drug-loading carriers in medicine, or as interventional embolic materials. Common drug-loading microsphere materials include polyvinyl alcohol microspheres, gelatin microspheres, sodium alginate microspheres, polylactic acid microspheres, and albumin microspheres. ball and so on. For example, liver cancer can be treated with interventional methods in clinical treatment, and the interventional material is embolic microspheres. The microspheres have two functions: first, the microspheres block the blood vessels in the tumor target blood vessels, blocking the nutrient source of the tumor cells. Second, the microspheres can be loaded with drugs, and the released drugs can play a role in curbing tumor growth. The patent name is "A Preparation Method of Polyvinyl Alcohol / Hydroxyapatite Composite Microspheres" (Ap...

AI Technical Summary

Problems solved by technology

[0010] Among the methods of the above-mentioned prior art, the electrostatic spray method is not suitable for temperature-sensitive, heat-labile protein polypeptide microspheres, and it is also difficult to control the particle size of the microsphere particles

The emulsification cross-linking method takes a long time in the preparation of microspheres, is easily affected by the environment and is not suitable for the large-scale preparation of microspheres, and the cross-linking agent has certain toxicity

The phase separation method needs to use a large amount of organic solvents in the preparation process, but these solvents are difficult to remove from the microspheres and bring certain toxicity, so this method is easily affected by the addition of coagulants and solvent residues

The solvent evaporation method is affected by temperature. If the temperature is too low, the microsphere formation time will be prolonged and the encapsulation efficiency will be reduced; The burst release is severe, and the particle size of the microspheres will become larger

[0011] There are many problems in the existing technology, such as the particle size of the prepared microspheres cannot be adjusted, the production process is complicated and easily affected by the environment, and it is not convenient for mass production, there are restrictions on the loading of temperature-sensitive drugs, the development effect is not good, and the microspheres are loaded with drugs. The rate is not high, the sustained release effect is not ideal, etc.

Therefore, the current microspheres mainly have the problems of complex and unstable production process and low drug loading capacity.

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