Benpipralin compound preparation for treating cough and preparation method of benpipralin compound preparation

A compound preparation, the technology of benproperine, applied in the field of medicine, can solve the problems of weak antitussive effect, affecting work and life, and not lasting time, and achieve the effect of inhibiting gastric acid secretion

Inactive Publication Date: 2022-05-24
徐娴娴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the cough persists or changes from acute to chronic, it often brings great pain to the patient and affects work and life.
[0003] At present, the single preparation of benproperine used to treat cough has a certain antitussive effect, but the antitussive effect is not strong and the time is not long-lasting

Method used

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  • Benpipralin compound preparation for treating cough and preparation method of benpipralin compound preparation

Examples

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Effect test

preparation example Construction

[0017] A preparation method for the compound preparation of the benproperine for the treatment of cough, is characterized in that: comprise the following steps:

[0018] Step 1, take by weighing the benproperine and cimetidine raw materials of corresponding amounts according to the parts by weight of each component of the compound preparation, for subsequent use;

[0019] Step 2, take an appropriate amount of the auxiliary materials required for the prepared dosage form, for subsequent use;

[0020] Step 3. According to the preparation method of the corresponding preparation in pharmacy, mix the raw materials of benproperine, cimetidine and the auxiliary materials required for the preparation of the modified preparation, and prepare corresponding tablets, capsules, granules, dry mixes respectively. Suspension, oral solution or syrup.

Embodiment 1

[0022] In parts by weight, the compound preparation includes the following components: 0.2 parts of benzproperine, 2 parts of cimetidine, and the rest are auxiliary materials.

[0023] Step 1, take by weighing 2 grams of benproperine and 20 grams of cimetidine crude drugs in corresponding amounts, for subsequent use;

[0024] Step 2, get an appropriate amount of the auxiliary materials required for preparing the above-mentioned crude drug into granules, for subsequent use;

[0025] Step 3: According to the preparation method of pharmaceutical granules, the above-mentioned raw materials and auxiliary materials are mixed to prepare granules, so that each generation contains 20 mg of benproperine and 200 mg of cimetidine.

Embodiment 2

[0027] In parts by weight, the compound preparation includes the following components: 1 part of benproperine, 12 parts of cimetidine, and the rest are auxiliary materials.

[0028] Step 1, take by weighing 1 gram of benproperine and 12 grams of cimetidine raw materials for subsequent use;

[0029] Step 2, take by weighing the appropriate amount of auxiliary materials required to prepare the above-mentioned bulk drug into tablets, for subsequent use;

[0030] Step 3: According to the pharmaceutical tablet preparation method, the above-mentioned raw materials and auxiliary materials are mixed to prepare tablets, so that each tablet contains 20 mg of benproperine and 240 mg of cimetidine.

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Abstract

The invention discloses a benazolin compound preparation for treating cough and a preparation method of the benazolin compound preparation. The compound preparation comprises the following components: benpipralin and cimetidine in a ratio of (0.01-0.03): (0.1-0.3). The raw material medicines in corresponding parts are taken, proper auxiliary materials are added according to corresponding preparation methods of pharmaceutics, and the raw material medicines can be respectively prepared into dosage forms such as tablets, capsules, solutions, syrup, dry suspensions or granules. Benpipralin is a peripheral non-addictive cough relieving medicine and is mainly used for relieving cough caused by various reasons. The cimetidine is a histamine H2 receptor impedance agent, is a hepatodrug enzyme inhibitor, and can inhibit the activity of hepatodrug enzyme and slow down the metabolism of benpipralin, so that the blood concentration of benpipralin is improved, and the curative effect of benpipralin is enhanced; and the cimetidine alleviates the stimulation of the benpipralin to the stomach by inhibiting gastric acid secretion, and reduces the gastrointestinal tract side effect of the benpipralin.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound preparation of benproperine for treating cough and a preparation method thereof. Background technique [0002] Cough is a common symptom of respiratory tract inflammation, which is caused by inflammation, foreign body, physical or chemical stimulation of the trachea, bronchial mucosa or pleura, and has a protective effect of removing foreign bodies and secretions from the respiratory tract. However, if the cough does not stop or changes from acute to chronic, it often brings great pain to patients and affects work and life. [0003] At present, the single preparation of benproperine for treating cough has a certain antitussive effect, but the antitussive effect is not strong and the time is not long. Benzproperine and cimetidine are prepared into compound preparations, because cimetidine is histamine H 2 Receptor antagonists, which are also liver drug enzyme inhibit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4453A61K31/4164A61P11/14A61P1/04
CPCA61K31/4453A61K31/4164A61P11/14A61P1/04A61K2300/00
Inventor 徐娴娴
Owner 徐娴娴
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