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Method for preparing traditional Chinese medicine by utilizing compound microorganism fermentation liquor, composition and application of composition

A technology of compounding microorganisms and fermentation liquid, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems that the adaptability of traditional Chinese medicinal materials needs to be improved, the extraction of full medicinal properties cannot be achieved, and the fermentation is incomplete. Significant immune bidirectional regulation, improving the fermentation efficiency of traditional Chinese medicine, avoiding structural damage and volatilization loss

Active Publication Date: 2022-07-01
周洪龙
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The prior art discloses a method of fermenting Chinese herbal medicines to prepare compound Chinese medicines, but the adaptability of the usual fermentation methods to Chinese herbal medicines needs to be improved, and the extraction of full medicinal properties cannot be realized, especially in large-scale production, the fermentation is not complete, and the fermentation products The efficiency is low and the fermentation cycle is long, so there is a need for a high-efficiency fermentation method that can be applied to the preparation of traditional Chinese medicine compositions

Method used

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  • Method for preparing traditional Chinese medicine by utilizing compound microorganism fermentation liquor, composition and application of composition
  • Method for preparing traditional Chinese medicine by utilizing compound microorganism fermentation liquor, composition and application of composition
  • Method for preparing traditional Chinese medicine by utilizing compound microorganism fermentation liquor, composition and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] In this example, five different traditional Chinese medicine formulations were used as fermentation substrates, and the addition of red yeast rice (treatment 1), the addition of composite microorganisms (treatment 2), the simultaneous addition of red yeast rice and composite microorganisms (treatment 3), and the addition of composite microorganism fermentation broth (treatment 3) were used. Treatment 4), simultaneously add steamed glutinous rice and compound microorganism fermentation broth (treatment 5) five different microbial strain cultures and inoculation methods, carry out 90-day low-temperature solid fermentation to the Chinese medicinal material, and observe the fermented medicinal substrate with the naked eye after the fermentation is completed. and the appearance of the filtrate. A total of five treatments were set in the experiment, and for each prescription, a medicinal substrate that was added with 20Wt% steamed glutinous rice and inoculated with strains and...

Embodiment 2

[0110]In this embodiment, the traditional Chinese medicine composition is prepared by using the red yeast yeast fermentation broth and the composite microorganism fermentation broth for low-temperature solid fermentation of the traditional Chinese medicinal materials of the same traditional Chinese medicine formula. The fermented liquid was prepared as the traditional Chinese medicine composition 2.

[0111] Among them, the traditional Chinese medicine formula is: 2000 grams of steamed black rice, 2000 grams of Gynostemma pentaphyllum, 1000 grams of turtle shell, 1000 grams of turtle shell, 1000 grams of wolfberry fruit, 1000 grams of epimedium, 1000 grams of honey, and 300 grams of Trichospora , Ganoderma lucidum 300 grams.

[0112] The red yeast rice fermentation broth is prepared as follows: 6wt% red yeast rice (that is, 6% of the total weight of Chinese medicinal materials) is added 15 times (by weight) and soaked in cooling boiled water for more than 40 hours, and steamed...

Embodiment 3

[0200] In this example, large-scale low-temperature solid fermentation of traditional Chinese medicinal materials is carried out by preparing a composite microbial fermentation broth.

[0201] 1. Preparation of compound microbial fermentation broth

[0202] Preparation of red yeast fermentation broth: take 200 kilograms of red yeast rice, add 1.6 tons of cooled boiled water to soak for 48 hours, add 300 kilograms of steamed black rice and honey, and stir well, then add 300 kilograms of compound microorganism bacteria liquid, at 28-30 ℃ Under the conditions, the viscous liquid with fluidity is obtained by fermenting for 2 weeks, which is the composite microorganism fermentation broth.

[0203] 2. Preparation of medicinal bases

[0204] The medicinal substrate is prepared by mixing the traditional Chinese medicinal materials and the prepared composite microorganism fermentation broth.

[0205] The Chinese medicinal materials include: 0.8 ton steamed glutinous rice / 0.8 ton stea...

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Abstract

The invention discloses a method for preparing a traditional Chinese medicine composition by using a compound microorganism fermentation broth, which is characterized by comprising the following steps: mixing traditional Chinese medicinal materials and the compound microorganism fermentation broth to prepare a medicinal matrix, the compound microorganism fermentation liquid is prepared by mixing bacteria, saccharomycetes and monascus purpureus and performing liquid fermentation; performing low-temperature solid fermentation on the medicinal substrate to obtain a fermented medicinal substrate; and extracting the fermented medicinal matrix by adopting a liquid medium, and filtering to remove medicine residues to obtain filtrate, namely the traditional Chinese medicine composition. According to the method, structural damage and volatilization loss of effective components caused by high temperature when traditional Chinese medicines are extracted in a traditional decoction mode can be avoided, extraction of the effective components of the traditional Chinese medicines is improved, meanwhile, low-temperature fermentation can keep the naturalness of the medicines in the formula, ganoderma lucidum is generated in the fermentation process, and the medicine properties of the traditional Chinese medicine formula are exerted to the maximum extent.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for preparing traditional Chinese medicines by using compound microorganisms, a traditional Chinese medicine composition prepared by the method, and uses thereof. Background technique [0002] The prior art discloses a method for preparing compound traditional Chinese medicines by fermenting Chinese medicinal materials, but the adaptability of the usual fermentation methods to traditional Chinese medicinal materials needs to be improved, and the extraction of full medicinal properties cannot be achieved, especially in large-scale production, the fermentation is not complete, and the fermentation products The rate is low and the fermentation period is long, so a high-efficiency fermentation method that can be applied to the preparation of traditional Chinese medicine compositions is required. SUMMARY OF THE INVENTION [0003] The present application disclose...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K36/815A61P1/16A61P3/00A61P37/04A61P37/02A61P39/00A61K35/586A61K35/644
CPCA61K36/899A61K36/424A61K35/586A61K36/815A61K36/296A61K35/644A61K36/068A61K36/074A61P1/16A61P3/00A61P37/04A61P37/02A61P39/00A61K2236/19A61K2236/331A61K2300/00Y02A50/30
Inventor 周洪龙李坤
Owner 周洪龙
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