Application of laurazolette polypeptide in preparation of medicine for relieving doxorubicin cardiotoxicity
A larezole polypeptide and larezole technology are applied in the directions of drug combinations, pharmaceutical formulations, peptide/protein components, etc., to achieve the effects of preventing and treating cardiotoxicity, reducing myocardial enzyme content, and improving systolic and diastolic functions.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0031] 1. Experimental animals and grouping
[0032] SPF grade 6-8 week-old male C57BL / 6 mice, weighing about 18-20 g, were purchased from Beijing Speifu Laboratory Animal Co., Ltd. Raised in the Experimental Animal Center of Zhengzhou University.
[0033] The experimental groups included: oral PBS group (PBS group), oral PBS+injection Dox group (Dox group), oral Laazotide group (LA group), oral Laazotide+injection Dox group (LA+Dox group).
[0034] 2. Processing method
[0035] PBS group and Dox group: 1 week before the first injection of Dox, both groups were intragastrically administered 200 μl of PBS every day, and continued to be administered by intragastric administration every other day after the first Dox injection until the end of the experiment.
[0036] LA group and LA+Dox group: 1 week before the first injection of Dox, 200 μl of Larazotide was administered by gavage every day, after the first Dox injection, it was continued by gavage every other day until the en...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com