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Antithrombin nucleotides and proteins from horn fly

An antithrombin, protein technology, applied in the direction of peptide/protein composition, anti-peptide structure protease inhibitor immunoglobulin, protease inhibitor, etc., can solve the problem that reocclusion is not universally effective and so on

Inactive Publication Date: 2001-10-31
AUBURN UNIV
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Problems solved by technology

Unfortunately, heparin has not proven to be universally effective in preventing reocclusion in patients with myocardial infarction with a degree of vessel occlusion greater than or equal to 70%, especially in patients with severe residual coronary stenosis

Method used

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  • Antithrombin nucleotides and proteins from horn fly
  • Antithrombin nucleotides and proteins from horn fly
  • Antithrombin nucleotides and proteins from horn fly

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Embodiment Construction

[0024] The present invention provides methods and compositions for preventing blood-sucking insects (blood-sucking) in livestock and for treating thrombosis in mammals. The composition comprises proteins from the salivary glands of the blood-sucking insect Hornfly, C. westernis, as described by Yeates et al. (1999) Annu. Rev. Entemol. 44:397-428. Western horn flies belong to the suborder Cyclorrhapha of the order Diptera. Additionally provided is the nucleotide sequence encoding the antithrombin protein. The protein is named thrombostatin, and its main function is to prevent blood clotting by inhibiting the activity of thrombin (factor II).

[0025] By "blood-sucking" is meant that another organism feeds on the blood of the host organism. By "blood-sucking infection" is meant a host-parasite relationship involving the parasite feeding on the blood of the host. By "thrombosis" is meant the formation, development or presence of a thrombus. The so-called "antithrombin activit...

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Abstract

The present invention provides compositions and methods for preventing blood-sucking infection in livestock, isolated protein with antithrombin activity and nucleotide sequence encoding the protein. A protein named thrombostatin was isolated from the salivary gland of horn fly western horn fly. The composition can be used as a veterinary vaccine to prevent infective horn flies from sucking blood on domestic animals. The proteins of the invention are also useful in the treatment of thrombosis.

Description

field of invention [0001] The present invention relates to veterinary vaccines for preventing livestock from being infected with blood-sucking insects and medical treatment of thrombosis. Background of the invention [0002] It is estimated that livestock production losses due to ectoparasitic infections exceed $2.26 billion annually in the United States (Byford et al. (1992) J. Anim. Sci, 70:579-602). Among the 5-6 major arthropod pest species concerned, the western horn fly, Haematobia irritans linnaeus, is the most important and the most widespread. The economic impact of it on livestock production in the United States is estimated at $730.3 million per year. In Canada, control of this ectoparasite, which affects livestock production, could reduce losses by $71-107 million per year in 1977 dollars (Haufe and Weintraub (1985) Canadian Entomology (Can. Entomol.) 117:901-907). In South America, however, the economic impact of livestock production from this blood-sucking f...

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Application Information

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IPC IPC(8): A61K39/00C07K14/81C12N1/21C12N15/15
CPCA61K2039/51A61K39/00C07K14/811
Inventor E·W·卡普M·S·卡普
Owner AUBURN UNIV
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