Stable non-aqueous single phase viscons vehicles and formulations utilizing such vehicles

A non-aqueous, carrier-based technology, applied in the field of stable uniform mixed preparations, which can solve problems such as toxicity
CN1339962AInactive Publication Date: 2002-03-13INTARCIA THERAPEUTICS INC

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INTARCIA THERAPEUTICS INC
Publication Date
2002-03-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1 x 10<7> reciprocal second.
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Description

field of invention

[0001] The present invention relates to stable non-aqueous single-phase adhesive biocompatible carriers that can suspend beneficial substances and uniformly disperse said substances at low flow rates, and in particular relate to beneficial substances in a stable non-aqueous single-phase biocompatible viscosity A stable homogeneously mixed formulation in a carrier. references

[0002] The numbers in square brackets ([ ]) in relevant parts of this specification refer to the following documents. 1. Wang, et al. J. Parenteral Sci. Tech., 42: S4-S26 (1988). 2. Desai, et al. J. Am. Chem. Soc., 116:9420-9422 (1994). 3. Chang, et al. Pharm. Tech., pp. 80-84 (June, 1996). 4. Manning, et al. Pharm. Res., 6:903-918 (1989). 5. Hageman, Drug Dev. Ind. Pharm, 14:2047-2070 (1988). 6. Bell,. Biopolymers, 35:201-209 (1995) 7. Zhang, et al. Pharm. Res., 12:1447-1452 (1995). 8. PCT Publication No. 98 / 001589. PCT Publication No. 981625010. Knepp, et al. Pharm. Res., 15(7...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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