Medicine composition for treating tumor and cardiac and cerebral vascular diseases

A composition and cardiovascular technology, applied in the direction of cardiovascular system diseases, drug combinations, anti-tumor drugs, etc., can solve the problems of large side effects and adverse reactions, insignificant therapeutic effects, affecting treatment and use, etc., to reduce drug side effects and Adverse reactions, improvement of biochemical indicators, effect of shrinking tumor mass

Inactive Publication Date: 2003-02-26
蔡海德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The defects when the above drugs are used alone as drugs are: single curative effect, some drugs only treat cardiovascular and cerebrovascular diseases, and some drugs only treat tumors, and the therapeutic effect is not obvious, and the side effects and adverse reactions are relatively large, which affects the treatment and use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1   and ：10μg，0.1mg，10mg。 preparation approach ：GMP()，，， to ，0.22μm、、、，。 Embodiment 2   and ：2000μg，200mg，2000mg，3000mg。 preparation approach ：GMP，，，、、。 Embodiment 3  200μg，100mg，200mg，250mg。 preparation approach ：GMP，，，、。 Embodiment 4  ：800μg，100mg。，100mg。 preparation approach ：GMP，，，，、、、。 Embodiment 5   and ：300μg，200mg，150mg，100mg。 preparation approach ：GMP，，，，，3～5μm，，、、，。 Embodiment 6   and ：100mg，200μg，300mg。GMP，，，，、、。 Embodiment 7

[0021] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Example 1 The composition of the present invention is made into a small-volume injection. Components and contents: 10 μg of alprostadil, 0.1 mg of aspirin, and 10 mg of ribonucleic acid. Preparation method: according to the GMP standard for drug production (good manufacturing practice for pharmaceuticals), and according to the composition formula, add appropriate amount of auxiliary materials, dissolve in water for injection to completely dissolve each component, filter with 0.22 μm membrane, fill, press stopper, Sterilized and made into small-volume injections. Example 2 The composition and content of the suppository made from the composition of the present invention: 2000 μg of alprostadil, 200 mg of ribonucleic acid, 2000 mg of aspirin, and 3000 mg of reduced glutathione. Preparation method: According to the GMP standard of drug production and according to the composition formula, the components are mixed, an appropri...

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PUM

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Abstract

The present invention is one kind of medicine composition for treating tumor and cardiac and cerebral vascular diseases and the composite medicine contains Prostaglandin E1, ribonucleic acid, aspirin or aspirin-DL-lysine and reductive glutathione. The medicine may be prepared into various forms, and has obvious clinical curative effect. The medicine composition can be used to treat both tumor and cardiac and cerebral vascular diseases and has less side effect and adverse reaction.

Description

technical field [0001] The present invention relates to the pharmaceutical composition of treatment tumor, and cardiovascular and cerebrovascular diseases, particularly relate to by alprostadil (prostaglandin E 1 ), ribonucleic acid, aspirin (or lysine-pirin), a pharmaceutical composition composed of reduced glutathione. Background technique [0002] It is known that alprostadil can treat cardiovascular and cerebrovascular diseases, resist radiation and regulate immunity, improve microcirculation, and be used as an adjuvant drug for tumor radiotherapy and chemotherapy, but its use is affected by its side effects and adverse reactions such as injection pain. [0003] It is known that ribonucleic acid can directly or indirectly inhibit the DNA synthesis of cells and thus lead to the death of tumor cells, but it cannot treat cardiovascular and cerebrovascular diseases. [0004] It is known that aspirin and lysine are drugs for treating cardiovascular and cerebrovascular diseas...

Claims

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Application Information

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IPC IPC(8): A61K31/7088A61P9/10A61P35/00
Inventor 蔡海德
Owner 蔡海德
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