Biodegradable vehicles and delivery systems of biologically active substances
A bioactive substance and biodegradation technology, applied in the field of biodegradable carriers and release systems of bioactive substances, can solve the problem of difficulty in individualizing BAS dosage, and achieve the effect of easy injection and easy preparation
Inactive Publication Date: 2003-08-27
A・J・舒克拉
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
It is therefore often difficult, if not impossible, to individualize the dose of BAS (or vary the BAS loading in these delivery systems)
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment example 1
[0061] Example 1 Preparation of biodegradable carrier.
[0062] The polymer (50% w / w 50 / 50 poly(lactic-co-glycolic acid) or poly(lactide-co-glycolide)) was dissolved in a minimum amount of acetone. Then add 50% triethyl citrate (TEC), and stir well. With continuous stirring, the mixture was heated to 60-75°C to evaporate the acetone. The resulting formulation is a gel-like base. Example 2
example 2
[0063] Repeat Example 1 with 10% w / w 50 / 50 poly(lactic-co-glycolic acid) or poly(lactide-glycolide) and 90% w / w TEC to prepare a liquid matrix. Example 3
example 3
[0064] Repeat Example 1 with 20% w / w 50 / 50 poly(lactic-co-glycolic acid) or poly(lactide-glycolide) and 80% w / w TEC to obtain a viscous liquid matrix. Example 4
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Biodegradable vehicle and delivery systems of physiologically, pharmacologically and biologically active substance(s) (BAS) are provided. The biodegradable vehicles may be prepared by blending biodegradable polymers and plasticizers using a novel solvent evaporation method. This method involves dissolving the biodegradable polymer or copolymer and a plasticizer or mixtures of plasticizers into a volatile solvent or mixtures of volatile solvents. The volatile solvent is then removed using vacuum or at an elevated temperature or using a combination of both vacuum and elevated temperature. The biodegradable vehicle can be used as filler or spacer in the body. Biologically active substances (BAS) can be added to the biodegradable vehicle at any step during or after preparing the biodegradable vehicle, or just prior to using the biodegradable delivery system. This biodegradable delivery system provides controlled release of the BAS over the desired period of time. The biodegradable vehicle or BAS-loaded biodegradable delivery system can be injected, implanted, smeared or applied in vivo in an animal, bird or human.
Description
[0001] Cross References to Related Applications [0002] This application claims priority to US Patent Application Serial No. 09 / 605,661, filed June 28, 2000, the teachings of which are incorporated herein by reference. field of invention [0003] The present invention provides biodegradable carriers and delivery systems that can be mixed with one or more physiologically, pharmacologically and biologically active substances (BAS). The biodegradable carrier (without carrying any BAS) can be used as a biodegradable filler or spacer to fill in cavities or tissues in animals, birds and humans. One or more BASs can be mixed with a biodegradable carrier. A delivery system loaded with BAS can be used to control the release of BAS from the delivery system over an extended period of time. The viscosity, rheology, hydrophilicity and hydrophobicity, and in vivo degradation rate of the biodegradable carrier and the release system loaded wit...
Claims
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IPC IPC(8): A61K47/30A61F2/00A61F13/00A61K9/00A61K9/06A61K9/08A61K9/16A61K9/22A61K31/00A61K38/00A61K47/08A61K47/10A61K47/14A61K47/16A61K47/22A61K47/32A61K47/34A61K47/42A61L27/00A61L31/04A61L31/14A61L31/16C08L101/16
CPCA61K9/1694A61K9/0024C08K5/11A61L31/16A61L31/148A61K47/10A61K47/14A61K47/34A61K9/1647A61K31/00A61L2300/602A61L31/141A61K47/22A61K9/06A61K9/0019A61L31/041
Inventor A·J·舒克拉
Owner A・J・舒克拉
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