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High performance antibiotic medicine composition

A technology of antibacterial drugs and compositions, which is applied in the field of high-efficiency antibacterial drug compositions, can solve the problems of no azlocillin sodium and tazobactam, achieve good chemical stability, be easy to popularize and apply, and enhance the effect of antibacterial activity

Inactive Publication Date: 2005-03-02
陶灵刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No combination of azlocillin sodium and tazobactam has been used so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 1.0 g of azlocillin sodium and 10.0000 g of tazobactam, mix them, and pack them in a 100-grade clean area with a relative humidity below 45% and meet the requirements of GMP.

Embodiment 2

[0031] Take 2.0 g of azlocillin sodium and 0.2000 g of tazobactam, mix them, and pack them in a 100-class clean area with a relative humidity of 45% or less and meeting GMP requirements.

Embodiment 3

[0033] Take 1.0 g of azlocillin sodium and 1.0000 g of tazobactam, mix them, and pack them in a 100-class clean area with a relative humidity of 45% or less and meeting GMP requirements.

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PUM

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Abstract

The present invention relates to high efficiency antibiotic medicine composition containing azlocillin sodium and tazobactam in the weight ratio of 0.1-10, optimally of 1-4. The medicine composition has obvious cooperative effect of azlocillin sodium and tazobactam and antibiotic capacity much higher than azlocillin sodium. The present invention has wide antibiotic spectrum, powerful bactericidal effect, high chemical stability and low toxicity, and the medicine composition is prepared into injection normally.

Description

Technical field [0001] The present invention relates to a high-efficiency antibacterial pharmaceutical composition, and more specifically to a high-efficiency antibacterial pharmaceutical composition containing azlocillin sodium and tazobactam. Background technique [0002] As we all know, due to the long-term and large-scale use of antibiotics in clinical practice, bacteria have become more and more resistant to antibiotics. For example, bacterial meningitis, otitis media, sepsis and pneumonia caused by Streptococcus pneumoniae are important pathogens. , Is the main pathogenic bacteria of children's out-of-hospital infections, and the first pathogenic bacteria for community infections in adults, especially the elderly. Because Streptococcus pneumoniae has developed resistance to penicillin and other β-lactam antibiotics, the 1990s Since penicillin-resistant Streptococcus pneumoniae has spread widely around the world, the therapeutic effect of the drug ...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61P31/04
Inventor 陈胜龙
Owner 陶灵刚
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