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Novel ceramide compound with cell fading inducing activity and its preparing method

A technology of ceramides and inducing cells, applied in the fields of organic chemistry, drug combination, anti-tumor drugs, etc., can solve the problems of compound reports with new skeleton structure, etc., and achieve the effect of rich sources

Inactive Publication Date: 2005-05-18
SHENYANG PHARMA UNIVERSITY
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Problems solved by technology

[0003] Ceramides are a class of compounds composed of sphingosine and long-chain fatty acids. In all isolated ceramides, the sphingosine moiety is 1,3,4-trihydroxyl or 1,3-dihydroxyl Type, 1-position sugar or no sugar, so far, there has been no report of a compound with a new skeleton structure like Altermides

Method used

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  • Novel ceramide compound with cell fading inducing activity and its preparing method
  • Novel ceramide compound with cell fading inducing activity and its preparing method
  • Novel ceramide compound with cell fading inducing activity and its preparing method

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Embodiment Construction

[0011] The raw material marine fungus used in the present invention is isolated from starfish collected from the sea area near Yantai, and identified as Alternalia sp. by Professor Tian Li from the First Institute of Oceanography of the State Oceanic Administration. Of course, the raw material is not limited to the above-mentioned areas, as long as the starfish can be used.

[0012] The marine fungus Alternalia sp. is purified and cultivated on potato medium (both fermentation and solid medium use this medium). The medium formula is: 200ml of potato juice, 2g of peptone, 1g of yeast powder, 10g of glucose, 15g of NaCl, and MgCl 2 ·6H 2 O 1.3g, KCl 0.1g, FePO 4 0.01g, H 2 O 1000ml.

[0013] The colony of the strain on the medium is dark brown, the conidiophores are dark, single branches, the conidia are dark brown to brown, with longitudinal and transverse septa, elliptic or oval, often arranged in chains, with beak-like appendages at the top, Based on this feature, it was ...

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Abstract

The present invention discloses a new kind of ceramide compound Altermides, which is extracted and separated from marine fungus Alternalia sp. fermenting liquid and has cell apoptosis activity. By means of the combined solvent extraction and column chromatography technology, one series of ceramide compounds is obtained from the fermenting liquid. The compounds have wide material source and is expected to become new anticancer medicine.

Description

Technical field: [0001] The invention relates to the extraction and separation of biologically active compounds from the fermentation liquid of marine fungi, in particular to the novel ceramide compound Altermides which has the activity of inducing cell apoptosis and is extracted and separated from the fermentation liquid of marine fungus Alternalia sp. Background technique: [0002] Marine microorganisms have proven to be a rich source of novel antibiotic, antineoplastic and antiinflammatory drugs (Fenical, W. Chem. Rev., 93, 1673-1683 (1993).). In recent years, a lot of active compounds with novel structures have been isolated from the metabolites of marine microorganisms. The research on marine microorganisms mainly includes marine bacteria, fungi, actinomycetes and marine cyanobacteria. With the deepening of research on marine bacteria In recent years, there have been more and more studies on marine fungi. It has been proved that marine fungi can produce more new active ...

Claims

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Application Information

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IPC IPC(8): A61P35/00C07D207/14
Inventor 裴月湖张海龙田黎
Owner SHENYANG PHARMA UNIVERSITY
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