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Complex tissue of tissue-engineered bone and cartilage and external constructing method thereof

A technology of tissue engineering bone and tissue engineering, applied in tissue culture, biochemical equipment and methods, prostheses, etc., can solve the problems of repair failure, easy mutual displacement of tissues, affecting the repair effect of tissue defects, etc., and solve the problem of fixation , maintain structural integrity and reduce the difficulty of construction

Inactive Publication Date: 2005-06-29
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) If a single tissue-engineered bone and tissue-engineered cartilage are transplanted at the same time, the interface is flat, and the two tissues are easy to shift each other, resulting in repair failure. At present, there is no ideal fixation measure for this
(3) The cells of bone and cartilage have completely different functions. If the constructed single tissue-engineered bone and tissue-engineered cartilage are directly compounded, since the scaffold material has a mesh-like structure, the seed cells in different tissues will pass through the tissue interface in the Free movement between the two tissues, which greatly affects the repair effect of tissue defects, and even leads to repair failure

Method used

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  • Complex tissue of tissue-engineered bone and cartilage and external constructing method thereof
  • Complex tissue of tissue-engineered bone and cartilage and external constructing method thereof

Examples

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Effect test

Embodiment 1

[0017] Tissue-engineered bone and cartilage composite tissue, involving tissue-engineered bone tissue and tissue-engineered cartilage tissue, tissue-engineered bone tissue and tissue-engineered cartilage tissue are fitted together through interfacial joints with concave-convex grooves and convex structures. . The groove and protrusion structure of the bonded interface can be as figure 1 and figure 2 As shown, there is a rectangular or trapezoidal protrusion on the tissue engineering bone 1, and a rectangular or trapezoidal groove matching the rectangular or trapezoidal protrusion on the tissue engineering bone 1 binding surface on the tissue engineering cartilage 3, the two kinds of tissue The grooves and the protrusions are fitted together, and there is a biological protein gel layer 2 in the joint interface of the two tissues. In addition to preventing the free migration of different seed cells between the two tissues through the interface, the biological protein gel laye...

Embodiment 2

[0019] This embodiment relates to a method for constructing tissue-engineered bone and tissue-engineered cartilage composite tissue in vitro, and the method includes the following processes:

[0020] (1) Preparation of scaffold materials for tissue construction in vitro: Prepare or purchase scaffold materials of the desired shape that can be used for tissue engineered bone or tissue engineered cartilage with molds, and perform interface pretreatment to make the tissue engineered bone scaffold materials and tissue The interface of engineering cartilage scaffold materials combined with each other becomes the interface with mutual concave-convex relationship; the combined concave-convex structure can be as follows: figure 1 and figure 2 The shape shown in .

[0021] (2) In vitro construction of a single tissue-engineered bone and tissue-engineered cartilage: using existing tissue-engineered bone and tissue-engineered cartilage construction methods, a large number of in vitro ex...

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Abstract

The invention discloses a tissue engineering bone and cartilage complexed tissue, wherein the tissue engineering bone and tissue engineering cartilage are bonded together through recesses and projections in concave-convex relation arranged on the bonding interfaces, biological albumen gel is sprayed into the two tissue interface. The invention also discloses the method for constructing the complex tissue extracorporally. The disclosed tissue structure has the advantages of perfect histological structure, secure and convenient assembly and easy accessible raw materials.

Description

technical field [0001] The invention relates to a tissue-engineered bone-cartilage composite tissue for repairing tissue and organ defects, and a method for constructing the composite tissue in vitro. Background technique [0002] At present, the effective measure for the clinical treatment of serious defects or dysfunction of tissues and organs is tissue and organ transplantation, but this treatment method has many defects, such as: limited source of donor tissues and organs, immune rejection of transplanted tissues and organs, and increased probability of viral infection Wait. In the 1980s, with the in-depth development of basic disciplines such as cell biology and engineering materials, scientists began to boldly explore new methods to reasonably solve this world medical problem. The concept of "tissue engineering" was born from this, which is to apply the principles and methods of engineering and life sciences to prepare biologically active substitutes to restore, maint...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/00C12N5/08
Inventor 段小军杨柳
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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