Venous injection of secnidazole

A technology of secnidazole and injection, applied in the field of intravenous injection of secnidazole, can solve the problem of no injection production and marketing, etc.

Inactive Publication Date: 2005-10-12
湖南医药工业研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This variety is mainly used clinically for amoebiasis, giardiasis, urogenital trichomoniasis, and bacterial vaginosis. It has been sold in tablets, capsules, and suspensions abroad, with a specification of 250 mg / kg. Tablets, 500mg / tablet and 750mg / tablet, many manufacturers in China are developing tablets and capsules of this variety, but none of these injections are produced and marketed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 2.5g of secnidazole, add about 700ml of water for injection (or isotonic solution), stir to dissolve, add water for injection (or isotonic solution) to 900ml, adjust the pH to 5.5~6.5, stir evenly, filter, and remove from the container Add water for injection (or isotonic solution) to 1000ml, fine filter, check the content of intermediate products, potting (50ml / bottle, 100ml / bottle, 250ml / bottle, 500ml / bottle), sterilize at 115°C for 30 minutes, clarity Check, pack, and serve. The test results are shown in Table 1.

[0016] name

[0017] Grain

Embodiment 2

[0019] Take about 700ml of water for injection, add 250g of secnidazole, 50g of 2-hydroxypropyl-β-cyclodextrin, 100g of mannitol, stir to dissolve, add water for injection to 900ml, adjust the pH to 5.5-6.5, stir well, filter, and Add water for injection to the container to 1000ml, fine filter, check the content of the intermediate product, pack into 2ml / bottle, and freeze-dry.

[0020] name

Embodiment 3

[0022] Take about 700ml of water for injection, add 125g of secnidazole, 100g of β-cyclodextrin, and 150g of hydroxypropyl cellulose sodium, stir to dissolve, add water for injection to 900ml, adjust the pH to 5.5-6.5, stir well, filter, and remove from the container Add water for injection to 1000ml, fine filter, check the content of the intermediate product, pack into 2ml / bottle, and freeze-dry to obtain.

[0023] name

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PUM

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Abstract

An intravenous injection of secindazole is prepared from the secnidazole as active component and the pharmacologically acceptable carrier. Its advantage is quickly taking its high curative effect.

Description

Technical field: [0001] The present invention relates to secnidazole intravenous injection. technical background: [0002] Secnidazole (Secnidazale) belongs to 5-nitroimidazole drugs and metronidazole, tinidazole have the same anti-anaerobic spectrum and anti-anaerobic activity, in the treatment of amoebic protozoa, giardiasis, trichomonas More pronounced features are seen with urogenital disease and bacterial infections of the genitourinary tract. This variety is mainly used clinically for amoebiasis, giardiasis, urogenital trichomoniasis, and bacterial vaginosis. It has been sold in tablets, capsules, and suspensions abroad, with a specification of 250 mg / kg. Tablets, 500mg / tablet and 750mg / tablet, many domestic manufacturers are developing tablets and capsules of this variety, but no injections of this kind are produced and marketed. [0003] In clinical application, injections can directly enter human blood, and the effect is quick and obvious after administration. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4164A61P31/10A61P33/02
Inventor 李梅莲陈海波魏云钟硕宇肖方青马宁
Owner 湖南医药工业研究所有限公司
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