Pharmaceutical composition for treating rheumatic and rheumatoid diseases and its preparation process

Abstract

The invention discloses a pharmaceutical composition for treating rheumatic and rheumatoid diseases and its preparation process, wherein the medicinal composition is obtained through mixing Chinese ephedra, common juniper, Myricaria laxiflora, Artemisia sieversiana Willd and fragrant rhododendron leaf with root of red rooted saliva and astragalus root.

Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine, relates to a pharmaceutical composition for treating rheumatism and rheumatoid diseases, and also relates to a preparation process of the pharmaceutical composition. Background technique

[0002] Rheumatism and rheumatoid arthritis are autoimmune diseases mainly characterized by chronic inflammation of the joints. It is also one of the most difficult diseases to cure in the world. The pathogenesis is still unclear. According to the survey, it is preliminarily determined that there are more than 3.6 million patients with this disease. At present, most of the clinical analgesic and anti-inflammatory treatments are based on chemical drugs. Western medicines such as "aspirin", "butazone", and "ibuprofen" can only relieve symptoms and reduce pain, but they have many side effects and cause pain. Patients bring other pains and burdens, while most domestic technologies are still in the stage ...

Examples

Embodiment 1

[0099] Embodiment 1: the preparation of pharmaceutical granule of the present invention

[0100] 1. Formula (by weight percentage)

[0101] Ephedra 10%, Juniper 15%, Salvia 10%, Astragalus 10%

[0102] Cypress branch 15%, Artemisia grandis 20%, Rhododendron 20%

[0103] 2. Process

[0104] ① Take the four flavors of Juniper, Rhododendron, Artemisia grandis and Shuibazhi, add 10 times the amount of water, extract the volatile oil by steam distillation, and clathrate the volatile oil with β-cyclodextrin in a water bath at 45°C. Dry and pulverize; extract the medicinal residue and filtrate of volatile oil and keep it for later use;

[0105] ②Extract Salvia miltiorrhiza with 95% ethanol, recover the ethanol in the extract, filter and concentrate to obtain a thick paste;

[0106] ③Decoct the ephedra and astragalus with 10 times the amount of water for 3 times, 1 hour each time, combine the decoction, let it stand, remove the precipitate, filter, and concentrate to obtain a thic...

Embodiment 2

[0110] Embodiment 2: the preparation of pharmaceutical tablet of the present invention

[0111] 1. Formula (by weight percentage)

[0112] Ephedra 20%, Juniper 20%, Salvia 15%, Astragalus 5%

[0113] Cypress branch 20%, Artemisia grandis 10%, Rhododendron 10%

[0114] 2. Process

[0115] ① Take the four flavors of Juniper, Rhododendron, Artemisia grandis and Shuibazhi, add 10 times the amount of water, extract the volatile oil by steam distillation, and clathrate the volatile oil with β-cyclodextrin in a water bath at 45°C. Dry and pulverize; extract the dregs and filtrate of the volatile oil and keep them for later use;

[0116] ②Extract Salvia miltiorrhiza with 95% ethanol, recover the ethanol in the extract, filter and concentrate to obtain a thick paste;

[0117] ③Decoct the ephedra and astragalus with 10 times the amount of water for 3 times, 1 hour each time, combine the decoction, let it stand, remove the precipitate, filter, and concentrate to obtain a thick paste;...

Embodiment 3

[0121] Embodiment 3: the preparation of medicine capsule of the present invention

[0122] 1. Formula (by weight percentage)

[0123] Ephedra 15%, Juniper 10%, Salvia 5%, Astragalus 15%

[0124] Cypress branch 20%, Artemisia grandis 20%, Rhododendron 15%

[0125] 2. Process

[0126] ① Take the four flavors of Juniper, Rhododendron lanceolata, Artemisia grandis and Cypress branch, add 10 times the amount of water, extract the volatile oil by steam distillation, and clathrate the volatile oil with β-cyclodextrin in a water bath at 45°C. Dry and pulverize; extract the medicinal residue and filtrate of volatile oil and keep it for later use;

[0127] ②Extract Salvia miltiorrhiza with 95% ethanol, recover the ethanol in the extract, filter and concentrate to obtain a thick paste;

[0128] ③Decoct the ephedra and astragalus with 10 times the amount of water for 3 times, 1 hour each time, combine the decoction, let it stand, remove the precipitate, filter, and concentrate to obta...

technical field

[0001] The invention belongs to the field of traditional Chinese medicine, relates to a pharmaceutical composition for treating rheumatism and rheumatoid diseases, and also relates to a preparation process of the pharmaceutical composition. Background technique

[0002] Rheumatism and rheumatoid arthritis are autoimmune diseases mainly characterized by chronic inflammation of the joints. It is also one of the most difficult diseases to cure in the world. The pathogenesis is still unclear. According to the survey, it is preliminarily determined that there are more than 3.6 million patients with this disease. At present, most of the clinical analgesic and anti-inflammatory treatments are based on chemical drugs. Western medicines such as "aspirin", "butazone", and "ibuprofen" can only relieve symptoms and reduce pain, but they have many side effects and cause pain. Patients bring other pains and burdens, while most domestic technologies are still in the stage ...

Examples

Embodiment 1

[0099] Embodiment 1: the preparation of pharmaceutical granule of the present invention

[0100] 1. Formula (by weight percentage)

[0101] Ephedra 10%, Juniper 15%, Salvia 10%, Astragalus 10%

[0102] Cypress branch 15%, Artemisia grandis 20%, Rhododendron 20%

[0103] 2. Process

[0104] ① Take the four flavors of Juniper, Rhododendron, Artemisia grandis and Shuibazhi, add 10 times the amount of water, extract the volatile oil by steam distillation, and clathrate the volatile oil with β-cyclodextrin in a water bath at 45°C. Dry and pulverize; extract the medicinal residue and filtrate of volatile oil and keep it for later use;

[0105] ②Extract Salvia miltiorrhiza with 95% ethanol, recover the ethanol in the extract, filter and concentrate to obtain a thick paste;

[0106] ③Decoct the ephedra and astragalus with 10 times the amount of water for 3 times, 1 hour each time, combine the decoction, let it stand, remove the precipitate, filter, and concentrate to obtain a thic...

Embodiment 2

[0110] Embodiment 2: the preparation of pharmaceutical tablet of the present invention

[0111] 1. Formula (by weight percentage)

[0112] Ephedra 20%, Juniper 20%, Salvia 15%, Astragalus 5%

[0113] Cypress branch 20%, Artemisia grandis 10%, Rhododendron 10%

[0114] 2. Process

[0115] ① Take the four flavors of Juniper, Rhododendron, Artemisia grandis and Shuibazhi, add 10 times the amount of water, extract the volatile oil by steam distillation, and clathrate the volatile oil with β-cyclodextrin in a water bath at 45°C. Dry and pulverize; extract the dregs and filtrate of the volatile oil and keep them for later use;

[0116] ②Extract Salvia miltiorrhiza with 95% ethanol, recover the ethanol in the extract, filter and concentrate to obtain a thick paste;

[0117] ③Decoct the ephedra and astragalus with 10 times the amount of water for 3 times, 1 hour each time, combine the decoction, let it stand, remove the precipitate, filter, and concentrate to obtain a thick paste;...

Embodiment 3

[0121] Embodiment 3: the preparation of medicine capsule of the present invention

[0122] 1. Formula (by weight percentage)

[0123] Ephedra 15%, Juniper 10%, Salvia 5%, Astragalus 15%

[0124] Cypress branch 20%, Artemisia grandis 20%, Rhododendron 15%

[0125] 2. Process

[0126] ① Take the four flavors of Juniper, Rhododendron lanceolata, Artemisia grandis and Cypress branch, add 10 times the amount of water, extract the volatile oil by steam distillation, and clathrate the volatile oil with β-cyclodextrin in a water bath at 45°C. Dry and pulverize; extract the medicinal residue and filtrate of volatile oil and keep it for later use;

[0127] ②Extract Salvia miltiorrhiza with 95% ethanol, recover the ethanol in the extract, filter and concentrate to obtain a thick paste;

[0128] ③Decoct the ephedra and astragalus with 10 times the amount of water for 3 times, 1 hour each time, combine the decoction, let it stand, remove the precipitate, filter, and concentrate to obta...

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