Composition for treating upper respiratory tract infection and application

A technology for compositions and medicinal additives, which can be applied in the directions of drug combinations, respiratory diseases, medical preparations containing active ingredients, etc., and can solve the problems of increased bacterial resistance and uneconomical antibiotics.

Inactive Publication Date: 2006-02-22
江苏省药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although clinically this disease is often mixed with bacterial infection, long-term use of antibiotics is uneconomical and will lead to increased bacterial resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: The expectorant effect of Radix japonica oil / eucalyptus oil on mice (tracheal segment phenol red method)

[0017] Mice were randomly divided into four groups according to their body weight, blank control group (0.5ml / mice with normal saline) and intragastric administration group (0.1g / kg, 0.2g / kg, 0.3g / kg). 1 hour later, 0.5 ml / a 0.5% phenol red solution was intraperitoneally injected, and the animals were sacrificed 30 minutes later, the tissue around the trachea was stripped, an incision was cut from the thyroid cartilage, and 0.5 ml of alkaline saline was drawn with a gavage needle to flush the trachea. Aspirate the tracheal secretions for four consecutive times, combine the tracheal secretions, measure the OD value with a 721 spectrophotometer at a wavelength of 546, use phenol red as a standard curve, calculate the phenol red content (μg / ml) according to the curve, and compare it with the control. group comparison. The results showed that the oil of sag...

Embodiment 2

[0020] Example 2: Anti-inflammatory effect of Radix japonica oil / eucalyptus oil (1:1) on mice (mouse ear swelling method)

[0021] The healthy male mice were randomly divided into four groups, the blank control group (0.5ml / gavage of normal saline), the gavage administration group (0.2g / kg, 0.4g / kg, 0.6g / kg), and half of the mice were administered. After 1 hour, the left ear of each mouse was smeared with croton oil mixed with inflammatory agent for 25 hours, and the animals were sacrificed after 4 hours, and the same size ear pieces were placed on the same part of the ear with a 9mm steel gun and weighed, and the degree of edema was expressed as the weight gain of left and right ear edema. , the results show (see Table 2), the croton oil-induced inflammation of the mouse ear swelling has a significant inhibitory effect, and a good dose-effect relationship.

[0022]

[0023] Note: Compared with blank control group: * P ** P *** P<0.001

Embodiment 3

[0024] Example 3: Formulation composition

[0025] The medicinal composition provided by the present invention contains arborvitae oil, eucalyptus oil, medicinal diluent and medicinal excipients. The pharmaceutical composition can be administered orally, topically and intravenously, preferably orally.

[0026] Take soft capsules as an example: gelatin, glycerin, and water are used as capsule materials, and Nibelgin ethyl ester is used as preservatives. Astragalus seed oil / eucalyptus oil has exudation effect on capsule material, so add diluent (refined vegetable oil), the ratio of Astragalus seed oil / eucalyptus oil to diluent can be 1:0.2~5, preferably 1:0.5~2 . Each capsule contains fenugreek oil / eucalyptus oil (1:0.1-10) 50mg-350mg.

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PUM

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Abstract

The invention relates to a composition comprising litsea cubeba oil and eucalyptus oil by the weight ratio of 1:0.1-10. The composition has the actions of dispersing pathogenic wind, relieving pain, relieving cough and resolving phlegm.

Description

technical field [0001] The present invention relates to a composition comprising fenugreek oil and eucalyptus oil, which is preferably used for the treatment of upper respiratory tract infections such as acute and chronic bronchitis, acute and chronic sinusitis, acute and chronic rhinitis and the like. Background technique [0002] Upper respiratory tract infection is one of the most common diseases, mainly caused by bacterial infection, physical, chemical irritation or allergic substances caused by inflammation of the respiratory tract mucosa, cold, humid environment is often the cause of this disease, and viral infection is often this important factor in the pathogenesis of the disease. In the early stage of the disease, the respiratory mucosa is congested and edematous, and polymorphonuclear granulocytes and lymphocytes infiltrate the mucosa, resulting in an increase in respiratory secretions. After granulocytes enter the mucus, the mucus becomes purulent. As the diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61P11/02A61P11/00
Inventor 施敏锋陈家英苏国强
Owner 江苏省药物研究所有限公司
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