Wide focal domain phased array focusing ultrasonic system for heating deep tumour focus

Abstract

The present invention relates to a large focal field phase-controlled focusing ultrasonic system for heating deep tumor focus. Said system includes large focal field phase-controlled array focussing ultrasonic transducer activator device formed from N phase-controlled signal formation subsystems and N controllable power amplifier, large focal field phase-controlled array focusing ultrasonic transducer combined therapeutic head, medium water bag, stereo-combined motion device, circulating medium water treating device, several temperature detection devices and computer intelligent subsystem containing man-machine interactive peripheral equipment and computer aided therapeutic plane software package. Said invention also provides the concrete function and action of the above-mentioned every portion and working principle of said system.

Description

technical field [0001] The invention relates to an ultrasonic system for heating, in particular to a large focal area phase-controlled focused ultrasonic system for heating deep tumor lesions, and belongs to the technical field of biomedical engineering. Background technique [0002] As a drug carrier, the nanoparticle thermosensitive liposome with temperature as the key switch can carry the drug into the target tissue of the human body. When the target tissue of the human body is directional and conformally heated to 40-45°C, the liposome shell is opened, and the drug loaded in it is released at a specific point. This technology not only increases the local concentration of the drug, improves the lethality of tumor cells in the target tissue, but also avoids the harm caused by systemic administration to the human body, and greatly reduces the toxic and side effects. This kind of heating can not only open the drug carrier in the target tissue, but also increase the permeabi...

AI Technical Summary

Problems solved by technology

This technology has obvious shortcomings: the system uses a planar ultrasonic transducer, and its sound waves radiate along the vertical direction, and the energy is dispersed. The lower the sound intensity in the body, in order to ensure sufficient effective heating depth, the ultrasonic transducer must have a high enough radiation power, which will make the patient feel pain, burn the skin on the body surface, and even superficial tissues; only 16 arrays The elements are arranged and combined to form different shapes, and the conformability is poor; when the ultrasonic energy is radiated to the target tissue in the body, only the attenuation is not enhanced, so the effective heating depth is short, and it is difficult to meet the treatment requirements

There are obvious deficiencies in this technology: the system can only form a limited "focus area" and is not conformal. For tumor tissues with a certain shape and size, it must be focused and irradiated point by point to form a series of "ultrasonic therapy" to Completely covers the entire lesion tissue

Therefore, it is not suitable for tumor hyperthermia with a large therapeutic range, warm (the temperature of the target tissue is kept at about 43°C for a long time), and it is not suitable for directional opening of thermosensitive liposomes and carrier thermosensitive drugs. thermal synergistic therapy

Images