Luotongding oral cavity disintegration tablet and preparation thereof

Abstract

An oral disintegrating tablet of rotundine is prepared through pretreating and tabletting. Its advantages are high dissolving speed and less consumption of auxiliaries.

Description

technical field The invention relates to a rotundine orally disintegrating tablet and a preparation method thereof. Background technique Rotundine, whose chemical name is 2,3,9,10-tetramethoxy-5,8,13,13α-tetrahydro-6H-dibenzo[α,g]quinazine, is clinically used for analgesia , sedative, hypnotic, non-addictive analgesics, suitable for visceral pain caused by digestive system diseases (such as gastric ulcer and duodenal ulcer pain), general headache, menstrual pain and postpartum uterine contraction pain. Because it also has sedative and hypnotic effects in addition to its analgesic effect, it relieves the suffering of pain patients. Because of its clear curative effect and small side effects, Rotundine Tablets have been listed as Class A OTC drugs, but for many elderly people and children with weak swallowing function, it is not suitable for ordinary oral drug dosage forms such as tablets, capsules, etc. The drug compliance of the dosage form is poor; for the seriously ill p...

AI Technical Summary

Problems solved by technology

In addition, because light and high temperature can change the color of rotundine, the prepared tablets are often mottled or yellow, so how to prepare orally disintegrating tablets with uniform color and good appearance is another difficulty

Images