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Method for preparing composite delayed-release prepn. of non-narcotic analgesic

A technology for sustained-release preparations and analgesics is applied in the field of preparation of compound sustained-release preparations of non-narcotic analgesics to achieve the effects of improving curative effect, convenience of medication and compliance

Inactive Publication Date: 2006-06-14
王鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no compound sustained-release preparation of similar products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] Preparation of the immediate-release part: take an appropriate amount from items 1-6 in the above table, and stir and mix in a high-speed shear mixer granulator or a planetary mixer granulator. The mixture is placed in water or other coagulant to form granules, and then dried in a desiccator. Afterwards, the dried material was ground and then mixed with items 9 and 10 of the above table. Then use a tablet machine to compress it into microtablets with a single weight of 160 mg. The above-mentioned steps are conventional steps in tablet production at present.

[0043] Preparation of the sustained-release part: take an appropriate amount from items 1-3, 7, and 8 in the above table, and mix them in a high-efficiency shear mixing granulator or a planetary mixing granulator. The mixture is placed in water or other coagulant to form granules, and then dried in a desiccator. Afterwards, the dried material was ground and then mixed with items 9 and 10 of the above table. The...

example 4

[0055] Example 4: The present invention finds in experiments that ibuprofen and trimadol are used in combination in an appropriate ratio, which can improve the analgesic effect, reduce the dosage and side effects of trimadol. Similar formulations developed with the above preparations can also be prepared New compound sustained-release analgesic drug,

[0056] When 100mg / kg and 50mg / kg of ibuprofen are used alone, the analgesic effective rates to acetic acid writhing reaction are 40% and 30% respectively. When 30, 20, and 10 mg / kg of tramadol were used alone, the analgesic effective rates for writhing reactions were 50%, 20%, and 10%, respectively. However, after taking ibuprofen 100mg / kg and 50mg / kg respectively, and then giving tramadol 30, 20, and 10mg / kg respectively, the writhing reaction inhibition rate of animals in each group was higher than the corresponding dose of single drug. The analgesic effects of the two drugs showed obvious synergy. This experiment found that...

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Abstract

A composite slow-release non-stupefacient sedative contains fast-release component (25-75%), slow-release component (25-75%), colloidal polymer (6-50%) and enteric coating material (5-40%). Its preparing process is also disclosed.

Description

technical field [0001] The present invention relates to a compound sustained-release preparation containing common anti-inflammatory analgesics, such as ibuprofen or acetaminophen and another non-narcotic strong analgesic composition, such as tramadol hydrochloride and derivatives thereof Preparation and directional control technology, especially the detailed description of paracetamol and tramadol hydrochloride and its derivative compound sustained-release formulation and disintegration method, by improving the dosage and administration time, patients have better compliance sex. Background technique [0002] Acetaminophen plus codeine phosphate (Tylenol  plus codeine), exacerbated oxycodone tartrate (Vicodin  ), Hydroxycodone (Tylox  ) is a compound analgesic commonly used at present to relieve moderate and severe pain. In the two formulations of compound acetaminophen-codeine or compound acetaminophen-hydrocodone, codeine and hydrocodone play the main analgesic effe...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K9/52A61K31/135A61K31/192A61P25/04
Inventor 张书毅王进
Owner 王鸣
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