Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof

A technology of polyglutamate and hydrogel, which is applied in the direction of dressing preparations, skin care preparations, cosmetics, etc., can solve the problems of skin oiliness and achieve the effect of increasing health value and excellent moisturizing effect

Active Publication Date: 2010-04-21
TUNG HAI BIOTECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although, squalane has the advantage of moisturizing the skin surface by preventing water from evaporating from the skin surface, its oily nature makes the user's skin feel greasy

Method used

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  • Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof
  • Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof
  • Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0033] In this experimental example, a standard skin revitalizing moisturizing cream with the following formula was prepared to demonstrate that the Mg++ form of γ-polyglutamate and γ-polyglutamate hydrogel (made of Na+ form of γ-polyglutamate glutamate preparation) water retention effect. Propylene glycol was used as a control group for comparison, hyaluronic acid (HA) was used as a relative reference example, a small molecular weight Mg++ form of gamma-polyglutamate (called LM) with 200,000 to 400,000 daltons (called LM), with 1.15x106 Gamma-polyglutamate in the form of high molecular weight Mg++ to 1.35x106 daltons (called HM), and γ-polyglutamate with a molecular weight of 15x106 to 100x106 daltons or higher (cross-linked with polyglycerol polyglycidyl ether) - Polyglutamate hydrogel (prepared from γ-polyglutamate in Na+ form) as long-lasting moisturizer. The types and ratios of ingredients contained in exemplary cream formulations are listed in Table 2.

[0034] Table 2...

experiment example 2

[0038] The water retention effect on the skin was evaluated for the cosmetic product of Experimental Example 1. Take 0.2 grams of samples from each of the five products and spray evenly on an area of ​​about 25 cm2 on the skin surface of the inner side of the volunteer's arm. 10 volunteers participated in this experiment. The water retention of the skin surface was measured using a probe of a skin analyzer SHP88 manufactured by Courage+Khazaka Electronic Gmbh, Germany at 23° C. in an environment of a relative humidity of 60%. The water retention effect is expressed by the increase ratio (%) of electrical conductivity, as shown in Table 3. The results showed that products containing γ-polyglutamate in Mg++ form and γ-polyglutamate hydrogel (prepared from γ-polyglutamate in Na+ form) had better and longer-lasting water retention properties.

[0039] Table 3. Change in water retention over time after application of revitalizing moisturizing cream expressed as percent increase i...

experiment example 3

[0042]The cosmetic product of Experimental Example 1 was also evaluated for its effect on skin elasticity improvement. Take 0.25 grams of samples from each of the five products and evenly spray them on an area of ​​about 25 cm2 on the skin surface of the inner side of the volunteer's arm, once a day for one month. 10 volunteers participated in this experiment. The apparent skin elasticity was measured with a probe of Cutometer SEM 575 (manufactured by Courage+Khaazaka Electronic Gmbh, Germany) at 23°C in an environment with a relative humidity (RH) of 60%, once a week and expressed as the value of the apparent elasticity index R2. The higher the R2 value of the appearance elasticity index, the better the skin elasticity. The results are shown in Table 4. The results showed that γ-polyglutamate (HM) in the form of Mg++, γ-polyglutamate in the form of Mg++ (LM) and γ-polyglutamate hydrogels (composed of γ-polyglutamate in the form of Na+ Amino acid salt preparation) 4% 1CL co...

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Abstract

The present invention relates to the use of -polyglutamic acid ( -PGA, H form), and / or one or more of its salts (i.e., -polyglutamate in Na + form, -polyglutamate in K + form, -polyglutamate in NH4 + form, -polyglutamate in Mg ++ form, -polyglutamate in Ca ++ form) and / or -polyglutamate hydrogel as super moisturizer(s) in cosmetic products and personal care products.

Description

technical field [0001] The present invention relates to γ-polyglutamic acid (γ-PGA, H form), Na + Forms of γ-polyglutamate, K + Forms of γ-polyglutamate, NH 4 + Form of γ-polyglutamate, Mg ++ Forms of γ-polyglutamate and / or Ca ++ Form of γ-polyglutamate and / or cross-linked γ-polyglutamate hydrogel (by Na + Forms of γ-polyglutamate, K + Forms of γ-polyglutamate, NH 4 + Form of γ-polyglutamate, Mg ++ Forms of γ-polyglutamate and / or Ca ++ Form of γ-polyglutamate prepared) in cosmetics and personal care products to provide desired functions, the functions include high moisturizing and water retention, improved wettability and low TEWL (transdermal moisture loss), softness and suppleness, smoothness and dryness, long-lasting effect, improved skin elasticity, good biocompatibility and improved skin health. Background technique [0002] Proper hydration and nutrition are integral to the health and beauty of human skin and hair. Excessive dryness caused by low humidity o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/84A61K8/86A61K8/72A61Q19/00A61Q5/00
CPCA61Q19/00A61K8/44A61K8/042A61Q19/02A61K8/88A61Q19/007
Inventor 何观辉杨头雄杨正
Owner TUNG HAI BIOTECH CORP
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