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Kadsura longipedunculata lignin extract and its preparing method and use

A technology of Schisandra chinensis and extract, which is applied in the field of extraction technology of effective parts of traditional Chinese medicine, can solve the problems of high cost and complicated process

Active Publication Date: 2006-08-09
NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent application adopts the steps of supercritical CO2 extraction followed by distillation, vacuum concentration, resin adsorption and ethanol elution, the process is complicated and the cost is high
However, there is no relevant literature report on the isolation and identification of the effective part of Schisandra chinensis for the treatment of insomnia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0044] Example 1-4 Extraction and detection of lignans from Schisandra chinensis

[0045] 1. Materials and Instruments

[0046] Materials: Schisandra chinensis (purchased from Anhui Bozhou Medicinal Materials Market, identified by Professor Wu Qinan from Nanjing University College of Traditional Chinese Medicine); macroporous resin (purchased from Xi'an Lanshen Exchange Adsorption Material Co., Ltd.); ethanol (purchased from Suzhou Dongwu Distillery ).

[0047] Instruments: multifunctional extraction tank (Wujin Menghe Pharmaceutical Machinery Factory); Shimadzu UV-1240 spectrophotometer; Shimadzu LC-10ATVP high performance liquid chromatography.

Embodiment 1

[0049] Take 50 kg of dried fruit of Schisandra chinensis, crush it, steam distill it with 10 times the amount of medicinal material for 3 hours, and filter to obtain medicinal residues. The dregs were decocted and extracted with 6 times the amount of medicinal materials in water for 30 minutes, filtered, and the filtrate was discarded (repeated twice). 90% ethanol reflux extraction of 10 times the amount of medicinal material, extracted twice, each time for 1 hour, combined two ethanol extracts, filtered to obtain 15L medicinal liquid, the obtained medicinal liquid was passed through a resin adsorption column (LSA-10), and the amount of resin It is 1 times the amount of medicinal material, and after the medicinal solution passes through the column bed, it is eluted with 95% ethanol, and the ethanol solution (including the flow-through and eluent) is collected, filtered, and the ethanol is recovered, evaporated to dryness in a water bath, and dried at 60°C to obtain Southern Sc...

Embodiment 2

[0051] Take 50kg of dried fruit of Schisandra chinensis, crush it, steam distill it with 8 times the amount of medicinal material for 4 hours, and filter to obtain medicinal residues. The dregs were decocted and extracted with 6 times the amount of medicinal materials, filtered, and the filtrate was discarded (repeated once). 95% ethanol reflux extraction of 8 times the amount of medicinal materials, extracted twice, each time for 1.5 hours, combined twice ethanol extracts, filtered to obtain 13L medicinal liquid, the obtained medicinal liquid was passed through a resin adsorption column (LSA-7), the amount of resin 1.5 times the amount of the medicinal material, the medicinal solution was eluted with 95% ethanol after passing through the column bed, the ethanol solution (including the flow-through liquid and the eluent) was collected, filtered, the ethanol was recovered, evaporated to dryness in a water bath, and dried at 70°C to obtain Southern Schisandra Lignan Extract.

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Abstract

The present invention relates to a method for preparing southern schisandra berry lignin extract. Said method includes the following steps: (a), distilling Chinese medicinal material southern schisandra berry by using water for 1-6 hr, (b), filtering to obtain residue; (c), decocting residue for 10-60 min, filtering; (d), using ethyl alcohol aqueous solution to extract residue, every time is 0.5-3 hr, filtering to obtain filtrate; (e), making the obtained filtrate be passed through resin adsorption column to obtain effluent, the described resin is selected from polar macroporous adsorption resin; (f) using ethyl alcohol to make elution to obtain eluent; and (g), combining effluent and eluent to obtain the liquid southern schisandra berry lignin extract.

Description

technical field [0001] The invention relates to the field of extraction technology of effective parts of traditional Chinese medicines, in particular to the extraction and preparation method and application of lignan extract from Schisandra chinensis. The present invention also relates to the composition containing the lignan extract of Schisandra chinensis and its application. Background technique [0002] Schisandra chinensis is the dry mature fruit of Magnolia plants Schisandra chinensis and Schisandra sphenanthera. The former is recorded as Schisandra chinensis according to the Chinese Pharmacopoeia in 2000, commonly known as northern Schisandra, and the latter is recorded as southern Schisandra. [0003] The chemical composition of southern Schisandra and northern Schisandra is similar, both contain volatile oil and lignans. However, the composition and content of lignans differ between the two. The lignan components of northern Schisandra are: Schisandrin A, Schisand...

Claims

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Application Information

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IPC IPC(8): A61K36/57A61P25/20A61K131/00
Inventor 徐丽华黄芳徐强
Owner NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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