Medicinal composition, preparation method and quality control method

A composition and drug technology, applied in the directions of drug combination, testing drug preparation, drug formula, etc., can solve the problems of reducing plasma TXB2 level and ratio, and achieve the effect of convenient use and portability and good curative effect.

Inactive Publication Date: 2007-02-21
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Animal experiments show that intravenous administration can reduce the level of plasma TXB2, reduce the ratio of Keto-PGF12 / TXB2, inhibit platelet aggregation caused by different inducers, and prevent cerebral infarction caused by the middle cerebral artery in rats. A single preparation has been widely used in the treatment of cardiovascular and cerebrovascular diseases, but so far, there has been no report on the combination of the two preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: preparation hawthorn leaf extract: 10 parts of hawthorn leaves (part is: kilogram or gram)

[0030] Take hawthorn leaves, crush them into a coarse powder that passes through a 10-mesh sieve, add 10 times the volume of 60% ethanol to reflux and extract for 3 times, combine the extracts, filter, recover the filtrate, and concentrate the ethanol to 60 ° C to measure the relative density of 1.05 to 1.15, add Heat and dissolve 2 times the weight and volume of medicinal materials in water, filter, pass the filtrate through a ZTC-1 macroporous adsorption resin column, wash the resin column with water 5 times the volume of the resin, then desorb with 30% ethanol, collect the 30% ethanol desorption solution, and recycle the ethanol to obtain Thick paste, namely the hawthorn leaf extract.

Embodiment 2

[0031] Embodiment 2: preparation hawthorn leaf extract: 1000 parts of hawthorn leaves (kg or gram)

[0032] Take hawthorn leaves, crush them into coarse powder, use ethanol as solvent to carry out percolation according to the percolation method under flow extract and extract, collect percolation liquid, recover ethanol under reduced pressure to a certain concentration, add an equal amount of water to dilute Finally, add petroleum ether for extraction, separate the water layer, extract with ethyl acetate, recover ethyl acetate under reduced pressure, and concentrate to dryness to obtain the hawthorn leaf extract.

Embodiment 3

[0033]Embodiment 3: preparation hawthorn leaf extract: 3000 parts of hawthorn leaves (kg or gram)

[0034] Take hawthorn leaves, add 60% ethanol to reflux extraction for 2 hours, filter, add 60% ethanol to the residue, wash 3 times, combine with the filtrate, recover ethanol, concentrate into a paste, add water to refrigerate, pass the water through the macroporous resin, and elute with ethanol , and recover ethanol under reduced pressure to obtain hawthorn leaf extract.

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PUM

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Abstract

A composite medicine in the form of injection or orally taken medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, apoplexy sequelae, cerebral thrombus, etc, is prepared from haw leaf or its extract and ozagrel. Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as a preparation method and a quality control method of the composition, belonging to the technical field of medicines. technical background [0002] Cardiovascular and cerebrovascular diseases, such as coronary heart disease, myocardial infarction, and thromboembolic cerebrovascular disease are a major chronic disease that threatens healthy people in the world, and become the number one killer that threatens human health. According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in recent decades, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth among the causes of death in my country, and rose to second and third respectively after 1975. Cardiovascular and cerebrova...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61K9/00A61P9/10A61P7/02G01N33/15A61K31/4164
Inventor于文风
OwnerBEIJING QI YUAN YI DE PHARMA RESEARCH CENTER