Lyophilized injection of lentinan and preparation process thereof
A technology of freeze-dried powder injection and lentinan, which is applied in the direction of freeze-drying transportation, antiviral agent, powder transportation, etc., can solve the problems of uneven suspension of aqueous solution, reduced use safety, loss of lentinan, etc., and achieve reduction of lentinan Loss, clinical use safety, the effect of uniform solution
Inactive Publication Date: 2010-08-25
成都普瑞法科技开发有限公司
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Problems solved by technology
At present, there are also reports of lentinan injection, which uses a single mannitol as a scaffold agent. The current production adopts the pH adjustment to neutrality and then filters, and dissolves with high-concentration sodium hydroxide, which is likely to cause the loss and decomposition of lentinan. Inhomogeneous suspension and other phenomena lead to reduced safety in use
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Abstract
The invention discloses a freeze dried of mushroom polysaccharide, which comprises the following steps: adopting neutral amino acid as rack agent; blending evenly; reducing the density of sodium hydroxide; filtering; adjusting pH value.
Description
technical field The invention relates to a lentinan freeze-dried powder injection, which belongs to the field of medicines. Background technique Lentinan is an active substance isolated from shiitake mushrooms with obvious anti-cancer effects. It was first discovered in Japan in 1969. It was first produced in Japan in 1986 and prepared into powder injections for sale abroad. It is mainly used clinically for gastric cancer, For rectal cancer and other digestive system cancers, its main route of administration is intravenous drip or injection. In 1988, my country began to import Japanese Ajinomoto lentinan and apply it clinically. Since 1982, Sichuan Institute of Antibiotics and Henan Pharmaceutical Industry Research Institute have successively extracted lentinan from the liquid of shiitake mushrooms cultured by submerged fermentation, named "lentinan", to distinguish lentinan from fruiting bodies. In 1986, Henan Kaifeng Pharmaceutical Factory produced Lentinan tablets. In th...
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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K9/19A61P35/00A61P1/16A61P31/20
Inventor 吴四灵王小林
Owner 成都普瑞法科技开发有限公司
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