Lyophilized injection of lentinan and preparation process thereof

Abstract

The invention discloses a freeze dried of mushroom polysaccharide, which comprises the following steps: adopting neutral amino acid as rack agent; blending evenly; reducing the density of sodium hydroxide; filtering; adjusting pH value.

Description

Technical field The invention relates to a lentinan freeze-dried powder injection, which belongs to the field of medicine. Background technique Lentinan is an active substance isolated from Lentinus edodes with obvious anti-cancer effects. It was first discovered in Japan in 1969. In 1986, Japan first produced and prepared Lentinan into powder injections and sold them abroad. It is mainly used clinically for gastric cancer, For digestive system cancers such as rectal cancer, the main route of administration is intravenous drip or bolus injection. In 1988, my country began to import lentinan from Ajinomoto of Japan and use it clinically. Since 1982, Sichuan Antimicrobial Research Institute and Henan Pharmaceutical Industry Research Institute have successively extracted lentinan from the mushroom liquid cultured by submerged fermentation, named "lentinan" to distinguish it from the lentinan extracted from the fruiting body. In 1986, Henan Kaifeng Pharmaceutical Factory produce...

AI Technical Summary

Problems solved by technology

At present, there are also reports of lentinan injection, which uses a single mannitol as a scaffold agent. The current production adopts the pH adjustment to neutrality and then filters, and dissolves with high-concentration sodium hydroxide, which is likely to cause the loss and decomposition of lentinan. Inhomogeneous suspension and other phenomena lead to reduced safety in use

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