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Growth promoting pharmaceutical implant

a technology of growth stimulating agents and pharmaceutical implants, which is applied in the field of growth promoting pharmaceutical implants, can solve the problems of respiratory disease and its consequent growth impairment, and achieve the effects of promoting physiological growth of an animal, simple and efficient and economical manufacturing, and enhancing the effect of growth stimulating agents

Inactive Publication Date: 2005-08-04
IVY ANIMAL HEALTH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0018] Therefore, the principal objects and advantages of the present invention are: to provide an animal growth promoting composition having in combination a growth stimulating pharmaceutical agent and at least one supplemental agent selected from parasiticides, antimicrobials, estrus suppressing compositions, somatotropins, gonadotropins and other agents that enhance the effect of the growth stimulating agents; to provide such a composition having a pellet system for the implantation in an animal; to provide such a composition having immediate as well as sustained delivery of both a growth stimulating pharmaceutical agent and at least one supplemental agent in order to synergistically promote physiological growth of an animal; to provide such a system which includes an implanter apparatus for subcutaneously injecting pellets in an animal through the bore of a hypodermic needle which is operably coupled with a pellet magazine and simultaneously introduces both growth stimulating pharmaceutical and supplemental agent doses that are contained in separate or common pellets; to provide such a system and method which permits injection of predetermined doses in a solid bio-erodi

Problems solved by technology

The procedure must also be performed quickly, since the animals are not entirely cooperative and may shake their heads to free the held ear.
Respiratory disease and its consequent growth impairment is a particular problem among crowded animals, such as is found in feedlots.

Method used

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  • Growth promoting pharmaceutical implant

Examples

Experimental program
Comparison scheme
Effect test

example i

[0050] An implant is produced of multiple pellets sized, shaped and numbered to fit as a stack in a single bore of a pellet magazine of an implanter. The pellets include six discrete pellets including a total of 20 milligrams of estradiol benzoate alternated with pellets including a total of 300 milligrams of ivermectin. One of the implants is placed subcutaneously in each pastured cow to be treated beneath the hide of the ear and the process is repeated every 150 days.

example ii

[0051] An implant is produced of multiple pellets sized, shaped and numbered to fit as a stack in a single bore of a pellet magazine of an implanter. The pellets include certain pellets having a total dose of 200 milligrams of trenbolone acetate and others having a total dose of 60 milligrams of melengestrol acetate. The implant is injected beneath the skin of the ear of a feedlot heifer.

example iii

[0052] A solid implant is produced containing a composition in a pellet form sized and shaped to fit a single bore of a magazine of a pellet implanter. The pellet composition comprises a total of 25 milligrams of estradiol and 1000 milligrams of tilmicosin phosphate. The implant is injected under the hide of the ear of a feed yard cow for promotion of growth coupled with and augmented by prophylactic treatment for respiratory disease.

[0053] As used herein the term supplemental agent is an agent that cooperates with the growth stimulating agent to provide greater physical growth in the animal receiving an implant with both a growth stimulating agent and the supplemental agent than would be expected from just the growth stimulating agent.

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Abstract

A combination growth promoting pharmaceutical pellet system which delivers doses of both a growth stimulating pharmaceutical agent and a supplemental agent that enhances the growth produced by the growth stimulating agent as part of a single procedure wherein the doses have a synergistic or augmentative effect on physiological growth and weight gain. The system includes an implanter apparatus for subcutaneously implanting pellets in an animal through the bore of a hypodermic needle which is operably coupled to a pellet magazine, and a plurality of pellets sized to be implanted through the needle and positioned in the magazine for selective alignment of a pellet with the needle. The pellets include at least one growth stimulating pharmaceutical agent dose pellet. The implant also includes a supplemental agent dose selected from the group of parasiticides, antibiotics, estrus suppressing compositions, somatotropins, gonadotropins and mixtures thereof. The various agents preferably include both immediate release and time delayed release components.

Description

BACKGROUND OF THE INVENTION [0001] The present invention is broadly concerned with a pellet implant system that administers a growth stimulating pharmaceutical pellet dosage in combination with a parasiticidal, antimicrobial, estrus suppressant and / or other supplemental pellet dosage subcutaneously in a single procedure in order to promote physiological growth which is synergistically augmented and promoted by control of parasites, microbes and / or estrus and the like. [0002] More particularly, it is concerned with an implantation device having a pellet magazine containing pellets having a growth stimulating pharmaceutical in combination with a parasiticide, an antimicrobial agent and / or an estrus suppressant or other supplemental agent in a growth promoting combination as well as an injection needle and structure permitting injection of the pellets from the magazine through the needle for implantation under the skin of an animal. The pellets are formulated to simultaneously deliver ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/565A61K31/57A61K31/7048A61K38/24A61K38/27A61K45/06
CPCA61K9/0024A61K31/565A61K31/57A61K31/7048A61K38/24A61K45/06A61K38/27A61K2300/00A61P5/00A61P33/00
Inventor KENISON, DALE C.ZOLLERS,, WILLIAM G. JR.
Owner IVY ANIMAL HEALTH
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