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Compositions Comprising Solid Particles Entrapped In Collapsed Polymeric Microspheres, And Methods Of Making The Same

Inactive Publication Date: 2009-06-18
ELC MANAGEMENT LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]In one aspect, the present invention relates to a topical composition comprising a dispersion of microspheres in a cosmetically or pharmaceutic

Problems solved by technology

However, whenever there are changes in the pH and temperature in the surrounding environment, the dispersed or suspended particles may agglomerate with one another and precipitate out of the composition.
Further, the smaller the particle size, the larger the active surface area, and the more susceptible such particulate components are toward adverse interactions or interference with other ingredients or components in the cosmetic or topical compositions, which may destabilize the cosmetic or topical compositions or reduce the overall performance thereof.

Method used

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  • Compositions Comprising Solid Particles Entrapped In Collapsed Polymeric Microspheres, And Methods Of Making The Same
  • Compositions Comprising Solid Particles Entrapped In Collapsed Polymeric Microspheres, And Methods Of Making The Same
  • Compositions Comprising Solid Particles Entrapped In Collapsed Polymeric Microspheres, And Methods Of Making The Same

Examples

Experimental program
Comparison scheme
Effect test

example i

[0061]Expancel 551 DE 20 d 60 (DE 20 stands for average particle size of 20 microns)—about 800 g is placed into a mixing chamber. Acetone in an amount of about 4,000 mL is added under 20 RPM. A gel is formed and about 343 g of ultra fine titanium dioxide (D 50 2 microns) are added to the gel. The combination of titanium dioxide and the gel is mixed until homogeneous. The acetone is removed by heating the combination in a vacuum chamber. The titanium dioxide particles are entrapped in the microspheres and the outer layer of the microsphere is over-coated with about 14 percent by weight of a Dow Corning 1107 silicone polymer. The final particle size of the TiO2-entrapping microspheres is measured using a Malvern Particle Size Analyzer, available from Malvern Instrument Scirocco 2000 at Worcestershire, UK and the result is between 5 to 8 microns.

example ii

[0062]Following the process outlined in Example I using Expancel 461 DE 40 d60 the same result is obtained, the final particle size of the TiO2-entrapping microspheres is between 5 to 8 microns.

example iii

[0063]Example I was repeated with irregular solid particles of Dow Chemical Saran F 310 (Polyvinylidene Chloride). This experiment was performed in order to prove ability of particles to be dispersed in a gelled polymer, regardless it's original shape or composition.

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Abstract

The present invention relates to topical compositions containing solid particles that are stabilized via entrapment by microspheres. Each of the microspheres contains a collapsed polymeric shell that has entrapped therein one or more solid particles. The solid particles are preferably formed of zinc oxide or titanium dioxide or both, which can readily be used either alone or in combination with other sunscreen agents to form sunscreen compositions of broader UV protection spectrum and enhanced photostability.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application No. 61 / 014,235 filed Dec. 17, 2007.FIELD OF THE INVENTION[0002]The present invention relates to topical compositions comprising stabilized particulate components, as well as methods of making the same.BACKGROUND OF THE INVENTION[0003]Cosmetic or topical compositions typically comprise one or more particulate components, such as, for example, pigments or dyes, fillers, thickeners, sunscreen agents, and the like. Such particulate components are often insoluble in the respective solvent or carrier system and if so remain dispersed or suspended in the cosmetic or topical compositions.[0004]However, whenever there are changes in the pH and temperature in the surrounding environment, the dispersed or suspended particles may agglomerate with one another and precipitate out of the composition. Further, the smaller the particle size, the larger the active surface area, and the...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K33/24A61K33/30A61Q17/04
CPCA61K8/0275A61K8/27A61K8/29A61K8/8164A61K9/0014A61K9/5026A61K8/025A61K33/24A61K33/30A61K2800/412A61Q17/04A61K2800/63A61K9/5073
Inventor SOJKA, MILAN F.CUMMINS, PHILLIPFTHENAKIS, CHRISTINA G.XAVIER, JEAN HARRY
Owner ELC MANAGEMENT LLC