Methods of treating vascular diseases characterized by nitric oxide insufficiency

a vascular disease and nitric oxide technology, applied in the field of vascular diseases characterized by nitric oxide insufficiency, can solve the problems of many advances in cardiovascular medicine, the overall improvement of cardiovascular health in the general population has not translated into comparable racial benefits, and the cardiovascular events are worse for blacks than whites, so as to improve the overall health of the general population, enhance the endogenous level, and stimulate endogenous synthesis
US20090226407A9Inactive Publication Date: 2009-09-10NITROMED
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
NITROMED
Publication Date
2009-09-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides methods of treating and / or preventing vascular diseases characterized by nitric oxide insufficiency by administering a therapeutically effective amount of at least one nitrosated angiotensin-converting enzyme inhibitor, nitrosated beta-adrenergic blocker, nitrosated cholesterol reducer, nitrosated calcium channel blocker, nitrosated endothelin antagonist, nitrosated angiotensin II receptor antagonist, nitrosated renin inhibitor, and optionally at least one compound used to treat cardiovascular diseases and / or at least one antioxidant, or a pharmaceutically acceptable salt thereof, and / or at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The antioxidant may preferably be a hydralazine compound or a pharmaceutically acceptable salt thereof. The compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase may preferably be isosorbide dinitrate and / or isosorbide mononitrate. The vascular diseases characterized by nitric oxide insufficiency include a cardiovascular disease and a disease resulting from oxidative stress.
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Description

RELATED APPLICATIONS

[0001] This application is (i) a continuation-in-part of U.S. application Ser. No. 10 / 679,257 filed Oct. 7, 2003, which is a continuation of U.S. application Ser. No. 09 / 697,317, filed Oct. 27, 2000, issued as U.S. Pat. No. 6,635,273, which claims priority to U.S. Provisional Application No. 60 / 179,020 filed Jan. 31, 2000, and U.S. Provisional Application No. 60 / 162,230 filed Oct. 29, 1999; and is (ii) a continuation of U.S. Application No. 10 / ______ filed Oct. 20, 2003, which is a continuation of U.S. application Ser. No. 10 / 415,136 filed Apr. 25, 2003, which is a § 371 of PCT / US01 / 14245 filed May 2, 2001 which claims priority to PCT / US00 / 29582 filed Oct. 27, 2000.FIELD OF THE INVENTION

[0002] The present invention provides methods of treating and / or preventing vascular diseases characterized by nitric oxide insufficiency by administering a therapeutically effective amount of at least one antioxidant or a pharmaceutically acceptable salt thereof, and at least o...

Claims

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