Treatment for dry eye conditions

a treatment and eye condition technology, applied in the field of treatment of dry eye conditions, can solve the problems of increased incidence of infectious diseases, severe visual impairment and blindness, ulceration and perforation of the cornea, etc., and achieve the effect of easing the symptoms of dry ey

Inactive Publication Date: 2010-09-02
CAN-FITE BIOPHARMA LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alteration, deficiency or absence of the tear film may lead to undesired dryness of the corneal epithelium, ulceration and perforation of the cornea, an increased incidence of infectious disease, and ultimately, severe visual impairment and blindness.
In dry eye the eye becomes dry either because there is abnormally high rate of evaporation of tears or because there is not enough tears being produced.
These solutions and ointments give some temporary relief, but do little to arrest or reverse any damaging conditions.

Method used

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  • Treatment for dry eye conditions
  • Treatment for dry eye conditions
  • Treatment for dry eye conditions

Examples

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Embodiment Construction

[0016]Dry eye conditions and syndromes encompass a constellation of diverse disease processes that produce objective clinical signs of keratoconjunctivitis sicca (KCS). The classic prototype of the dry eye syndrome is Sjögren's syndrome, but there are many other causes of KCS including cicatrising conjunctival diseases such as trachoma and pemphigoid, non-cicatrising syndromes causing specific dry eye findings, and atypical syndromes such as keratomalacia in which the eye is symptomatically and objectively dry but tear production is paradoxically normal.

[0017]The main symptom of dry eye is usually a scratchy or sandy feeling as if something is in the eye. Other symptoms may include stinging or burning of the eye; episodes of excess tearing that follow periods of very dry sensation; a stringy discharge from the eye; and pain and redness of the eye. Sometimes individuals with dry eye experience heaviness of the eyelids or blurred, changing, or decreased vision, although loss of vision...

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Abstract

The present invention provides a method for treating dry eye condition in an individual comprising administrating to said individual an amount of A3 adenosine receptor (A3AR) agonist, the amount being effective to ameliorate symptoms of dry eye in the individual. In accordance with one embodiment, the dry eye condition is manifested by one or more opthalmologic clinical symptoms selected from foreign body sensation, burning, itching, irritation, redness, eye pain, blurred vision, degraded vision and excessive tearing. A preferred A3RAg in accordance with the invention is N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide (IB-MECA).

Description

FIELD OF THE INVENTION[0001]The invention relates to compounds and methods useful in the treatment of dry eye conditions.BACKGROUND OF THE INVENTION[0002]The preocular tear film plays an important role in the maintenance of corneal integrity, the protection against infection and the preservation of visual acuity. A healthy tear film preserves the optical clarity and refractive power, provides lubrication of the ocular surface and protection from environmental and infectious attacks. These functions, in turn, are critically dependent upon the stability, tonicity and / or composition of the tear film structure. Healthy tears contain a complex mixture of proteins such as antimicrobial proteins (lysozyme, lactoferrin) and growth factors and inflammation suppressors, mucin which provides viscosity and stability of the tear and electrolytes for proper osmolarity. Alteration, deficiency or absence of the tear film may lead to undesired dryness of the corneal epithelium, ulceration and perfor...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/52A61P27/04
CPCA61K31/7076A61K31/52A61P27/04
Inventor FISHMAN, PNINAREITBLAT, TATIANACOHN, ILAN
Owner CAN-FITE BIOPHARMA LTD
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