Locally active "soft" antiandrogens

a local active, anti-androgen technology, applied in the field of antiandrogenic compounds, can solve the problems of increasing the risk of high-grade prostate cancer, interfering with androgen action, and having clinical ramifications for women, so as to reduce the likelihood of acne, baldness, seborrhea or hirsutism, and the lik

a local active, anti-androgen technology, applied in the field of antiandrogenic compounds, can solve the problems of increasing the risk of high-grade prostate cancer, interfering with androgen action, and having clinical ramifications for women, so as to reduce the likelihood of acne, baldness, seborrhea or hirsutism, and the lik

US20140011785A1Inactive Publication Date: 2014-01-09YALE UNIV
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  • Locally active "soft" antiandrogens
  • Locally active "soft" antiandrogens
  • Locally active "soft" antiandrogens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019]The following terms shall be used throughout the specification to describe the present invention.

[0020]The term “patient” is used throughout the specification to describe an animal, preferably a human, to whom treatment, including prophylactic treatment, with the compounds according to the present invention is provided. For treatment of the symptomology, conditions or disease states which are specific for a specific animal such as a human patient, the term patient refers to that specific animal. In most instances in the present invention, the patient is a human with acne, some degree of baldness (including complete baldness) or hirsutism.

[0021]The term “effective amount” is used throughout the specification to describe concentrations or amounts of compounds according to the present invention which may be used to produce a favorable change in the symptomology, disease or condition treated, whether that change is a decrease in or reversal of the effects of symptomology or diseas...

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Abstract

The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient. These compounds have the general chemical structure I, II, III or IV:

Description

RELATED APPLICATIONS AND GRANT SUPPORT[0001]The present application claims the basis of priority from U.S. provisional application Ser. No. 60 / 927,427, filed May 3, 2007, of identical title, the entire contents of which is incorporated by reference herein.[0002]The subject matter of this application was supported by NIH grant nos. NIH R01 CA-37799 and HL-61432. Consequently, the United States government retains certain rights in the invention.FIELD OF THE INVENTION[0003]The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient.BACKGROUND OF THE INVENTION[0004]Androgen action is the result of a physiologically complex sequence that is ultimately controlled by opposing pathways of steroid biosynthesis and catabolism. For decades it was assumed that the testicular secretory product, testosterone, is the predominant and...

Claims

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Application Information

Patent Timeline
09 Jan 2014
Publication
US20140011785A1
IPC
C07J41/00; C07J21/00; C07C235/74; C07J1/00
CPC
C07J41/0038; C07J1/0051; C07J21/003; C07C235/74; C07J1/007; A61P17/00; A61P17/02; A61P17/08
Inventors
HOCHBERG, RICHARD