Locally active "soft" antiandrogens

a local active, anti-androgen technology, applied in the field of antiandrogenic compounds, can solve the problems of increasing the risk of high-grade prostate cancer, interfering with androgen action, and having clinical ramifications for women, so as to reduce the likelihood of acne, baldness, seborrhea or hirsutism, and the lik

Inactive Publication Date: 2014-01-09
YALE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides new compounds and compositions that can be used to prevent acne, baldness, seborrhea, and hirsuitism. This helps to reduce the likelihood of these skin conditions occurring or coming back.

Problems solved by technology

While the availability of this wide array of therapeutic agents makes it possible to treat most forms of hyperandrogenic syndromes, this systemic therapy is not without its pitfalls.
This has raised the possibility that this large number of young men who would take Propecia for most of their lives for the treatment of alopecia, might be at increased risk of high-grade prostate cancer (14).
As discussed above, interfering with androgen action has clinical ramifications for women as well as men since women also have androgen dependent processes.
Thus, producing an androgen deficiency syndrome by pharmacological inhibition of androgen action carries significant health risks for both men and women.
While it is apparent that the inhibition of androgen action to treat acne and baldness in men and women, and hirsutism in women, is efficacious, it can carry serious risks.

Method used

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  • Locally active "soft" antiandrogens
  • Locally active "soft" antiandrogens
  • Locally active "soft" antiandrogens

Examples

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Embodiment Construction

[0019]The following terms shall be used throughout the specification to describe the present invention.

[0020]The term “patient” is used throughout the specification to describe an animal, preferably a human, to whom treatment, including prophylactic treatment, with the compounds according to the present invention is provided. For treatment of the symptomology, conditions or disease states which are specific for a specific animal such as a human patient, the term patient refers to that specific animal. In most instances in the present invention, the patient is a human with acne, some degree of baldness (including complete baldness) or hirsutism.

[0021]The term “effective amount” is used throughout the specification to describe concentrations or amounts of compounds according to the present invention which may be used to produce a favorable change in the symptomology, disease or condition treated, whether that change is a decrease in or reversal of the effects of symptomology or diseas...

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Abstract

The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient. These compounds have the general chemical structure I, II, III or IV:

Description

RELATED APPLICATIONS AND GRANT SUPPORT[0001]The present application claims the basis of priority from U.S. provisional application Ser. No. 60 / 927,427, filed May 3, 2007, of identical title, the entire contents of which is incorporated by reference herein.[0002]The subject matter of this application was supported by NIH grant nos. NIH R01 CA-37799 and HL-61432. Consequently, the United States government retains certain rights in the invention.FIELD OF THE INVENTION[0003]The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient.BACKGROUND OF THE INVENTION[0004]Androgen action is the result of a physiologically complex sequence that is ultimately controlled by opposing pathways of steroid biosynthesis and catabolism. For decades it was assumed that the testicular secretory product, testosterone, is the predominant and...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07J41/00C07J21/00C07C235/74C07J1/00
CPCC07J41/0038C07J1/0051C07J21/003C07C235/74C07J1/007A61P17/00A61P17/02A61P17/08A61P17/10A61P17/14A61P5/00A61P5/28
Inventor HOCHBERG, RICHARD
Owner YALE UNIV
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