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Layered Bodies, Compositions Containing Them and Processes for Producing Them

a technology of compositions and layers, applied in the field of layers, compositions containing them and production processes, can solve the problems of limited performance of conventional carriers, e.g. those used in macroscale drug delivery applications, and the challenge of creating micro- or nanometers, and achieve the effect of increasing the non-linear effect of ultrasound diagnostics

Inactive Publication Date: 2014-02-20
UCL BUSINESS PLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about layered bodies that can be used in various applications such as drug delivery, catalysis, and protecting sensitive agents. These bodies have advantages over prior art methods and can be produced quickly using electrohydrodynamic processes. The thickness of the layers can be controlled, allowing for more accurate prediction of degradation and release of active agents. The invention also provides a way to control the energy absorption characteristics of the layered bodies, which can be useful in ultrasound applications.

Problems solved by technology

Because of their small size, it is a considerable challenge to create the micro- or nanometre scale multilayer particles, capsules and fibres with specific properties.
Some methods of manufacturing the micro- or nanoscale species, while appearing initially promising, have suffered from their requirement to use surfactants or certain additives.
Conventional carriers, e.g. those used in macroscale drug delivery applications, are limited in their performance for a number of reasons, and may not be suitable for use in the techniques for making the micro- or nanometer scale multilayer particles, capsules and fibres.
A drawback of layer by layer deposition is the considerable time it takes to produce the multilayered species, and the required use of certain material to produce the adherence between adjacent layers.
While the process of Ahmed et al offered advantages over the prior art, it was limited in the types of multilayered structures it can produce.

Method used

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  • Layered Bodies, Compositions Containing Them and Processes for Producing Them
  • Layered Bodies, Compositions Containing Them and Processes for Producing Them
  • Layered Bodies, Compositions Containing Them and Processes for Producing Them

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0160]In this example, the syringe 1 of the device was loaded with the compound PFH (perfluorohexane), obtained from F2 Chemicals Ltd. This was supplied to channel W at a rate of 300 μl per minute.

[0161]Syringe 2 was loaded with ethanol containing 18 wt % of the polymer polymethylsilsesquioxane (PMSQ), obtained from Wacker Chemie AG, GmbH. This was supplied to channel X at a rate of 600 μl per minute.

[0162]Syringe 3 was loaded with PFH. This was supplied to channel Y at a rate of 300 μl per minute.

[0163]Syringe 4 was loaded with ethanol containing 18 wt % of the polymer polymethylsilsesquioxane (PMSQ). This was supplied to channel Z at a rate of 600 μl per minute.

[0164]The voltage applied to the needles was 20 kV.

[0165]A jet was found to form, which broke up to form droplets or capsules, i.e. an embodiment of the layered bodies of the invention. It is considered that the cross section of the capsules may be represented schematically by FIG. 4C. A collection of the capsules is shown ...

example 2

[0166]In this example, the syringe 1 of the device was loaded with the compound PFH (perfluorohexane), obtained from F2 Chemicals Ltd. This was supplied to channel W at a rate of 300 μl per minute.

[0167]Syringe 2 was loaded with ethanol containing 18 wt % of the polymer polymethylsilsesquioxane (PMSQ), obtained from Wacker Chemie AG, GmbH. This was supplied to channel X at a rate of 300 μl per minute.

[0168]Syringe 3 was loaded with PFH. This was supplied to channel Y at a rate of 300 μl per minute.

[0169]Syringe 4 was loaded with ethanol containing 18 wt % of the polymer polymethylsilsesquioxane (PMSQ). This was supplied to channel Z at a rate of 300 μl per minute.

[0170]The voltage applied to the needles was 20 kV.

[0171]A jet was found to form, which broke up to form droplets or capsules, i.e. an embodiment of the layered bodies according to the invention. It is considered that the cross section of the capsules may be represented schematically by FIG. 4C. A collection of the capsules...

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Abstract

A layered body comprising: a core region; at least one intermediate layer disposed around the core region; and an outer layer disposed around the at least one intermediate layer, wherein at least one of the at least one intermediate layers comprises a gas, the layered body having at least one dimension, measured across the body and through the core region, of 100 μm or less.

Description

[0001]The present invention relates to layered bodies, which may be in capsule or thread form, that typically have a size in the micro- or nanometer scale.BACKGROUND[0002]Micro- or nanometre scale multilayer particles, capsules and fibres are of increasing interest in a number of fields, including diagnostic and therapeutic applications. They can be used, for example, to deliver therapeutic agents, contrast agents, living cells, and other species to desired sites in vivo. Because of their small size, it is a considerable challenge to create the micro- or nanometre scale multilayer particles, capsules and fibres with specific properties. Some methods of manufacturing the micro- or nanoscale species, while appearing initially promising, have suffered from their requirement to use surfactants or certain additives. It would be desirable to produce micro- or nanometer scale multilayer particles, capsules and fibres without surfactants or potentially harmful additives.[0003]One of the des...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/70A61K9/48B29C47/06B29C48/21
CPCA61K9/70A61K9/4808B29C47/065A61K49/226B01J13/22A61K9/4816A61K9/4891Y10T428/2938Y10T428/2933B29C48/21
Inventor EDIRISINGHE, MOHANCHANG, MING-WEISTRIDE, ELEANOR
Owner UCL BUSINESS PLC
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