Peritoneal dialysate fluid generation system

Abstract

Systems and methods of generating peritoneal dialysate are provided. The systems and methods use a water purification module, a sterilization module and concentrates to prepare a bolus of peritoneal dialysate from source water for use with an non-integrated cycler.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of and priority to U.S. Provisional Patent Application No. 62 / 318,169 filed Apr. 4, 2016, the entire disclosure of which is incorporated by reference herein.FIELD OF THE INVENTION[0002]The invention relates to devices, systems, and methods for generating a peritoneal dialysate having purity and sterility characteristics suitable for Peritoneal Dialysis (PD). The peritoneal dialysate can be generated from water of variable quality using a dialysate generation flow path containing a sterilization module. The sterilization module can be any one or more of an ultrafilter, Ultraviolet (UV) light source, microbial filter, dialyzer, and combinations thereof. Peritoneal dialysate generation system and related methods are described that can automatically generate peritoneal dialysate fluid.BACKGROUND[0003]Peritoneal Dialysis (PD), including Automated Peritoneal Dialysis (APD) and Continuous Ambulatory Peritoneal ...

AI Technical Summary

Benefits of technology

[0056]The features disclosed as being part of the second aspect of the invention can be in the second aspect of the invention, either alone or in combination, or follow a preferred arrangement of one or more of the described elements.

Problems solved by technology

Peritonitis is a serious and common problem in the PD population that results in abdominal pain, fever, and cloudy dialysate.

Moreover, peritonitis is a contributing factor to death in 16% of deaths on PD, and remains a major cause for patients discontinuing PD and switching to HD.

Because traditional peritoneal dialysis systems require FDA-approved, pre-packaged dialysate, the dialysate can be expensive due to high manufacturing, shipping, and storage costs.

Shortages can also occur.

These problems are not mitigated by on-site dialysate preparation because the source water must still meet high fluid purity and sterility characteristics.

Such standards may be difficult to meet, particularly for continuous, automatic peritoneal dialysis machines designed for home use.

Known systems and methods require significant space to store peritoneal dialysate prior to use.

The known systems and methods require significant storage space and can deter the adoption of CAPD, APD, or TPD.

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