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Lung cancer biomarkers

a technology for lung cancer and biomarkers, applied in the field of asay methods, can solve problems such as lack of efficient means

Inactive Publication Date: 2018-03-15
MESO SCALE TECH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Challenges in the field of oncology include the lack of efficient means for early cancer detection and for specific cancer subtyping and for measuring and / or predicting responsiveness to therapy.

Method used

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  • Lung cancer biomarkers
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Measurement of Biomarkers Indicative of Lung Cancer

[0111]Serum samples from 40 heavy smokers, 44 NSCLC patients (30 stage 1 / II), 20 SCLC patients, and 24 healthy controls were tested in randomized order on twelve MSD multiplex panels containing ˜100 assays. Samples were tested in duplicates. Each plate contained eight calibrators in triplicates and QC samples. In general, the assay format was as follows, with minor alterations for specific assay panels as indicated in the assay protocols provided with each assay kit (supplied by Meso Scale Discovery, Rockville, Md.): (1) block MSD MULTI-SPOT® plate for 1 hour with appropriate MSD® blocking solution and wash; (2) add 25 μl assay diluent to each well, if specified; (3) add 25 μl calibrator, or sample (diluted as appropriate) to each well; (4) incubate with shaking for 1-3 hours (time as specified) and wash the well; (5) add 25 μl labeled detection antibody solution to each well; (6) incubate with shaking for 1-2 hours (time as specifi...

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Abstract

The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and / or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present application is a divisional application of U.S. Ser. No. 14 / 447,691, filed Jul. 31, 2014, which claims benefit of U.S. Provisional Application No. 61 / 945,006, filed Feb. 26, 2014; U.S. Provisional Application No. 61 / 860,958, filed Aug. 1, 2013; and the disclosures of which are incorporated herein by reference in their entireties.STATEMENT REGARDING FEDERALLY-SPONSORED RESEARCH[0002]This invention was made with federal support under HHSN261201000018C awarded by the national Cancer Institute. The U.S. government has certain rights in the invention.FIELD OF THE INVENTION[0003]This application relates to assay methods useful in the detection and treatment of lung cancer.BACKGROUND OF THE INVENTION[0004]Challenges in the field of oncology include the lack of efficient means for early cancer detection and for specific cancer subtyping and for measuring and / or predicting responsiveness to therapy. There is a need for new cancer bioma...

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/574
CPCG01N33/57423G01N2800/52
Inventor AGHVANYAN, ANAHITGLEZER, ELI N.KENTEN, JOHNKUMAR, SUDEEPNIKOLENKO, GALINASTENGELIN, MARTINVAITHILINGAM, SRIKANT
Owner MESO SCALE TECH LLC