Compositions and methods for treating CNS disorders

a technology of cns and compositions, applied in the field of compositions and methods for treating cns disorders, can solve the problems that progesterone is not consistently effective in the treatment of the aforementioned syndromes
US20190177358A1Inactive Publication Date: 2019-06-13SAGE THERAPEUTICS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
SAGE THERAPEUTICS
Publication Date
2019-06-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

Described herein are neuroactive steroids of the Formula (I):or a pharmaceutically acceptable salt thereof; wherein , A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and / or anesthesia.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation of U.S. Ser. No. 15 / 519,480 filed Apr. 14, 2017, which is a U.S. National Stage Application filed under 35 U.S.C. § 371 of International Patent Application No. PCT / US2015 / 056054, filed Oct. 16, 2015, which claims priority to U.S. Provisional Application No. 62 / 064,961, filed Oct. 16, 2014, the entire contents of which are incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] Brain excitability is defined as the level of arousal of an animal, a continuum that ranges from coma to convulsions, and is regulated by various neurotransmitters. In general, neurotransmitters are responsible for regulating the conductance of ions across neuronal membranes. At rest, the neuronal membrane possesses a potential (or membrane voltage) of approximately −70 mV, the cell interior being negative with respect to the cell exterior. The potential (voltage) is the result of ion (K+, Na+, Cl−, organic anions) balance across the neuron...

Claims

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