Method to design temporal patterns of nervous system stimulation

Abstract

The present invention relates to methods that enable one to design temporal patterns for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention relates to methods to design improved stimulation patterns and / or genetic algorithms for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention utilizes a model-based design to achieve a more optimal stimulation pattern for use in connection with a nervous system, one or more nerve cells, or nervous tissue (e.g., a human nervous system). In another embodiment, the model-based design of the present invention utilizes a systematic search method to identify parameters (e.g., design variables) that minimize a cost function (e.g., optimize the fitness of a particular design). In one instance, the system and method of the present invention is demonstrated via optimal temporal patterns of electrical stimulation for a nervous system, one or more nerve cells, or nervous tissue.

Description

RELATED APPLICATION DATA[0001]This application is a continuation of U.S. Utility application Ser. No. 16 / 472,466 filed on Jun. 21, 2019 which is a 35 U.S.C. 371 national stage filing of PCT Application No. PCT / US2017 / 067878 filed on Dec. 21, 2017, which claims priority to and is a non-provisional of U.S. Provisional Patent Application No. 62 / 437,356 filed Dec. 21, 2016 and entitled “Optimized Temporal Pattern of Brain Stimulation Designed by Computational Evolution,” each of which are hereby incorporated herein by reference in their entireties.GOVERNMENT RIGHTS STATEMENT[0002]This invention was made with Government support under Federal Grant No. R37 NS040894 awarded by the NIH. The Federal Government has certain rights in this invention.FIELD OF THE INVENTION[0003]The present invention relates to methods that enable one to design temporal patterns for the optimal stimulation of the nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention ...

AI Technical Summary

Benefits of technology

[0010]In one embodiment, the present invention provides systems and methods for the use of model-based computational evolution to design temporal pattern of stimulation that reduces the average stimulation frequency of DBS and preserved efficacy.

[0012]In still another embodiment, the present invention provides a device and methods for obtaining neural recordings during non-regular patterns of brain stimulation using a time-domain solution. In some embodiments, the device comprises an implantable pulse generator that is capable of generating and delivering non-regular patterns of stimulation while simultaneously recording neural activity. In other embodiments, the implantable pulse generator uses an amplifier-blanking paradigm that briefly grounds the inputs during a short period encompassing the stimulation pulse, thereby preventing the violation of the input specifications of the amplifiers (railing the amplifiers), and the short gaps in the data can be overcome with real-time or post-processing analysis. In various non-limiting embodiments, the neurological disorder addressed comprises a neurological disease. In certain non-limiting embodiments, the neurological disease comprises Parkinson's disease.

Problems solved by technology

Although dopamine replacement therapy treats the symptoms of PD, long-term use is complicated by the requirement for higher and more frequent dosing, motor fluctuations, and dyskinesias.

However, this therapy has not been optimized, and there have been few improvements in DBS since its introduction.

Nevertheless, high stimulation frequencies can cause stronger side effects and consume more energy than low frequency stimulation, leading to frequent surgical replacement of battery-powered, implanted pulse generators (IPGs).

IPG replacement surgeries are expensive and carry risks, including infection and miss-programming

Random patterns of DBS, even when delivered at a high average frequency, are not effective in ameliorating parkinsonian symptoms in rats, tremor in persons with essential tremor or bradykinesia in patients with PD.

Images