Hydrogel formulation with mild adhesion

a technology of hydrogel and mild adhesion, which is applied in the direction of antibacterial agents, capsules, aerosol delivery, etc., can solve the problems of hydrogel shrinkage, significant shrinkage, and hydrogel properties change, and achieve the effect of reducing the period of tim

Active Publication Date: 2018-06-05
ZOETIS SERVICE LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]By rapidly forming the hydrogel when applied, the method of forming a teat sealant is fast, clean, “touchless” (hands free), and simple. Because it forms in situ, the sealant is highly conformal to the teat interior or exterior surface which ensures a better seal against infection and that any included active agents are more efficiently delivered directly to the teat.
[0023]In another aspect, the present invention provides methods for reducing the withholding time of milk obtained from an animal being treated for mastitis for the production of a milk product, wherein the Hydrogel Composition is administered to the animal. The present invention also provides methods for reducing the withholding time of milk obtained from an animal being prophylactically treated for mastitis for the production of a milk product, wherein a Hydrogel Composition is administered to the animal.
[0177]The administering can be effective for treating or preventing a microbial infection in the mammary tissue of the animal. In particular, the microbial infection can be mastitis.
[0184]The treatment can be effective to reduce the period of time during which milk obtained from the animal must be withheld from use in the production of a milk product.
[0185]The treatment can be effective to reduce the period of time during which milk obtained from an animal being prophylactically treated for mastitis must be withheld from use in the production of a milk product.

Problems solved by technology

PVA macromer in water may be unstable under certain sterilization and storage conditions.
A pure PVA hydrogel tends to dry out over a few hours, and this drying leads to a significant shrinkage and property changes of the hydrogel.

Method used

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  • Hydrogel formulation with mild adhesion
  • Hydrogel formulation with mild adhesion
  • Hydrogel formulation with mild adhesion

Examples

Experimental program
Comparison scheme
Effect test

example 1

Formulations

[0277]Hydrogel formulations were prepared from two solutions, an oxidant solution and a reductant solution, which were combined to form the hydrogel. The two solutions contained some ingredients in equal parts (macromer and glycerol) but only the oxidant solution contained hydrogen peroxide and only the reductant solution contained Fe(II), ascorbic acid, and calcium chloride.

[0278]The components of the oxidant were mixed into a homogeneous solution. Once fully mixed, the oxidant component was dispensed into one part of a dual barrel syringe. The components of the reductant were similarly mixed into a homogenous solution. After thorough mixing, the reductant component was dispensed into the second part of the dual barrel syringe.

[0279]The macromers used in the formulations were PVA of the molecular weights noted, substituted with the noted amounts of N-acrylamidoacetaldehyde dimethyl acetal (NAAADA). The macromers were prepared applying the method of Example 15 from U.S. ...

example 2

Swelling and Adhesion Testing

[0284]For adhesion testing, samples were conditioned at 37° C. for 2 hrs prior to testing. Adhesion data were generated between 0 to 2 hours after in situ formation of the hydrogel composition. The swelling values provided herein were read after 72 hours of swelling time. Swelling to the recorded values occurred during the noted time frame, and it is understood that readings taken between in situ formation and the final reading time would have been less than the value recorded at 72 hours.

[0285]For adhesion testing, peel test samples were made using a 60 mm×50 mm×3 mm mold attached to damp (or wet) collagen with an affixed gauze backing to facilitate the peeling. To assess adhesion on these samples, a modified procedure from the standard 180° peel test was performed with the principal modification of setting the sample horizontally as opposed to vertically. A high-precision universal peel tester was used to measure the force to pull the backing “on itsel...

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Abstract

The present disclosure relates to methods, compositions, and devices for treatments related to mammary tissue in subjects, including reducing the incidence of mastitis. In particular, the disclosure can relate to creating a physical barrier on a teat surface, in a teat canal, or in a teat cistern for prophylactic treatment of mammary disorders.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims priority to U.S. Provisional Pat. App. No. 62 / 157,627, filed May 6, 2015, the disclosure of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention is generally in the field of compositions having mild adhesion and medical and health related uses of such compositions. The invention is also in the field of methods, compositions, and devices for protecting the udder from pathogenic load and the resultant decrease in the incidence of mastitis in an animal. In one embodiment, the invention is methods, compositions, and devices for creating a physical barrier on the teat and udder surface or in the teat canal of an animal for prevention and / or treatment of mammary disorders. In one embodiment, the methods and compositions are designed for use in mid- to late-gestation and during the animal's dry period. In one embodiment, the methods and compositions are designed for placement ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K47/32A61K9/00A61K45/06A61K9/06A61K31/546A61K31/745
CPCA61K47/32A61K9/0017A61K45/06A61K31/546A61K31/745A61K9/06A61P31/04A61K9/00A61K9/51C08L29/00
Inventor ZOOK, CHRISTOPHER A.SWEENEY, MICHAEL T.QUESNELL, REBECCA R.CLEMENTS, FIONA PATRICIARENE, CLAUDE-RAYMONDASFAW, BRUKTAWITKOKOTOFF, SARAH BARBARAUGBEDAH, DOMINIC DOMINICOVICH
Owner ZOETIS SERVICE LLC
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