Orally taken granule for treating malaria and preparation method thereof

Abstract

The invention discloses an orally taken granule for treating malaria and a preparation method thereof. The orally taken granule contains artesunate, coating material, stabilizer, filler, preservative and corrigent. 1000mg of oral liquid contains 60g of artesunate, 5g of coating material, 0.35g of stabilizer, 550g of filler, 1.2g of preservative and 5g of corrigent. The orally taken granule can overcome the shortage of infant medicines and can meet the requirement of infant for taste; plenty of documents and practices prove that the medicinal saccharose is taken as main filler, and meanwhile, the covering function of different coating materials for the bitter and the guiding functions of acesulfame and natural plant essence for gustation are surveyed, and the optimal tasty formula is screened through plenty of blinding data model researches.

Description

technical field

[0001] The invention relates to an oral granule for treating malaria and a preparation method thereof, belonging to the field of chemical preparations. Background technique

[0002] Artemisinin is extracted from the stems and leaves of the plant Artemisia annua. It is the most effective antimalarial drug after pyrimethamine, chloroquine and primaquine, especially for cerebral malaria and chloroquine-resistant malaria. It has been called by the World Health Organization as the only effective malaria treatment drug in the world. Since 1999, many companies have produced artemisinin drugs.

[0003] Its derivatives currently include artemether, artesunate, dihydroartemisinin, etc. According to the "Guidelines for the treatment of malaria" issued by the World Health Organization (WHO), malaria is an important cause of morbidity and death among children and adults in tropical countries. The cause, currently, is that malaria is estimated to kill more than 1 million ...

Examples

Embodiment 1

[0019] Embodiment 1: Oral granules for treating malaria, said oral granules comprising artesunate, coating materials, stabilizers, fillers, preservatives, flavoring agents; in parts by weight, in every 1000mg oral liquid It contains the following ingredients: 60 grams of artesunate, 5 grams of coating materials, 0.35 grams of stabilizers, 550 grams of fillers, 1.2 grams of preservatives, and 5 grams of flavoring agents.

[0020] The stabilizer is one or more of disodium edetate, sodium sulfite, sodium thiosulfate and sodium metabisulfite.

[0021] The coating material is hydroxypropylmethylcellulose, methylcellulose, hydroxyethylcellulose, polyethylene glycol, polyvinylpyrrolidone, hydroxypropylcellulose, ethylcellulose, carboxymethylcellulose One or more of sodium, polyvinyl acetal diethylamine acetate, gastric soluble acrylic resin, shellac, etc., adding one or more of titanium dioxide, talcum powder, aluminum lake, silicon dioxide, aluminum stearate Various.

[0022] The ...

technical field

[0001] The invention relates to an oral granule for treating malaria and a preparation method thereof, belonging to the field of chemical preparations. Background technique

[0002] Artemisinin is extracted from the stems and leaves of the plant Artemisia annua. It is the most effective antimalarial drug after pyrimethamine, chloroquine and primaquine, especially for cerebral malaria and chloroquine-resistant malaria. It has been called by the World Health Organization as the only effective malaria treatment drug in the world. Since 1999, many companies have produced artemisinin drugs.

[0003] Its derivatives currently include artemether, artesunate, dihydroartemisinin, etc. According to the "Guidelines for the treatment of malaria" issued by the World Health Organization (WHO), malaria is an important cause of morbidity and death among children and adults in tropical countries. The cause, currently, is that malaria is estimated to kill more than 1 million ...

Examples

Embodiment 1

[0019] Embodiment 1: Oral granules for treating malaria, said oral granules comprising artesunate, coating materials, stabilizers, fillers, preservatives, flavoring agents; in parts by weight, in every 1000mg oral liquid It contains the following ingredients: 60 grams of artesunate, 5 grams of coating materials, 0.35 grams of stabilizers, 550 grams of fillers, 1.2 grams of preservatives, and 5 grams of flavoring agents.

[0020] The stabilizer is one or more of disodium edetate, sodium sulfite, sodium thiosulfate and sodium metabisulfite.

[0021] The coating material is hydroxypropylmethylcellulose, methylcellulose, hydroxyethylcellulose, polyethylene glycol, polyvinylpyrrolidone, hydroxypropylcellulose, ethylcellulose, carboxymethylcellulose One or more of sodium, polyvinyl acetal diethylamine acetate, gastric soluble acrylic resin, shellac, etc., adding one or more of titanium dioxide, talcum powder, aluminum lake, silicon dioxide, aluminum stearate Various.

[0022] The ...