5 results about "AXL Protein" patented technology

The present application relates to the field of biological medicine and clinical diagnosis, and more particularly, the present application relates to a polypeptide having binding affinity to AXL protein and application thereof; the polypeptide has binding affinity to AXL protein, and therefore can be used for detecting AXL protein, so that the polypeptide has diagnostic or therapeutic use as a drug or molecular targeting reagent.

To provide an antibody specifically binding to Axl protein, an immunoconjugate and a pharmaceutical composition.SOLUTION: Provided are single-chain antigen-binding antibodies that specifically bind to Axl proteins, comprising a heavy chain variable region and a light chain variable region having specific amino acid sequences, wherein all of the amino acid sequence mutations to the specific amino acid sequences occur only in the framework regions, and wherein the antibodies have higher binding affinities to Axl proteins at a pH of a tumor microenvironment ranging from pH7. 8 to 7.0 compared to a non-tumor microenvironment ranging from pH5. 2 to 7.6. Also provided is an immunoconjugate comprising the single-chain antigen-binding antibody, a linker molecule, and one or more cytotoxic agents covalently attached to the single-chain antigen-binding antibody and the linker molecule. Further provided is a pharmaceutical composition comprising said single-chain antigen-binding antibody for use as a medicament for the treatment of carcinoma.SELECTED DRAWING: None

The present invention provides an antibody or antigen-binding fragment thereof targeting AXL protein, a preparation method and use. It further provides an isolated polynucleotide encoding the antibody or antigen-binding fragment thereof targeting AXL protein, and a vector comprising the isolated polynucleotide. The antibody targeting AXL provided by the present invention specifically binds to AXL protein, and can be used to mediate ADCC effect to kill tumors, or as a target recognition domain of CART cells to exert anti-tumor effect and prevent or treat tumors.

Antibodies that bind to AXL protein and variants thereof are described herein. AXL exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the MAbs of the invention provide a diagnostic composition for the treatment and management of cancer.

Antibodies that bind to AXL protein and variants thereof are described herein. AXL exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the MAbs of the invention provide a diagnostic composition for the treatment and management of cancer.