5 results about "Lipid soluble vitamins" patented technology

The present invention provides a pharmaceutical composition, the composition comprises a therapeutically effective amount of bumetanib, one or more specific antioxidants and other necessary one or more pharmaceutically acceptable pharmaceutic adjuvants, and the specific antioxidants are selected from one or more of fat-soluble vitamin C derivatives or phenolic antioxidants. In addition, the invention also discloses a method for improving the stability of the bumetanib pharmaceutical composition. According to the technical scheme, the problems of generation and growth of N-nitroso bumetanib and other related substances in the production and storage process of the bumetanib solid preparation are effectively solved, and the drug stability and the medication safety are remarkably improved.

The application discloses a method for simultaneously detecting retinoids and lipid-soluble vitamin metabolic marker groups in biological samples and matching reagents. The application is based on magnetic bead solid-phase extraction technology, significantly improves sample purification effect, and reduces matrix interference; in combination with a high-aqueous-phase reversed-phase chromatography system and a positive-negative ion switching multi-reaction monitoring mode, simultaneous separation and detection of seven retinoid molecules and a full spectrum of lipid-soluble vitamins are realized. The method has high sensitivity, strong specificity and wide detection range, and for the first time realizes one-stop analysis across species and sample types, thereby providing reliable platform support for clinical and scientific research applications.

The present application provides a kind of pharmaceutical composition, the composition comprises therapeutically effective amount of bucumidol, one or more specific antioxidants and other necessary one or more pharmaceutically acceptable pharmaceutical adjuvant, the specific antioxidant is selected from one or more of the following: lipid-soluble vitamin C derivative, or phenolic antioxidant.In addition, a method for improving the stability of bucumidol pharmaceutical composition is also disclosed.The technical scheme of the present application effectively solves the problem of the generation and growth of N-nitroso-bumetanide and other related substances in the production and storage of bucumidol solid preparation, significantly improves the stability of the drug and the safety of drug use.

The invention belongs to the crossing field of plant-based food and nanotechnology, and particularly relates to a vitamin E-coffee nanoparticle compound as well as a preparation method and application thereof, the vitamin E-coffee nanoparticle compound comprises coffee nanoparticles and vitamin E loaded on the surfaces of the coffee nanoparticles; wherein the coffee nanoparticles are nanoscale particles separated from a coffee extracting solution, and the coffee nanoparticles naturally carry polyphenol compounds; the vitamin E is loaded on the surfaces of the coffee nanoparticles through non-covalent acting force. The vitamin E-coffee nanoparticle compound is used for replacing a traditional coffee polyphenol extract, so that the problems of protein aggregation, precipitation and phase separation caused by interaction of free phenolic acid and vegetable protein are effectively avoided, and the product can be kept in a uniform colloidal state for a long time in the storage period. Meanwhile, the dispersity and the stability of the fat-soluble vitamin E in a water-phase system are greatly improved, and coffee polyphenol carried by the fat-soluble vitamin E is also retained.

The present invention relates to a lipophilic compound, a preparation method therefor and the use thereof. The lipophilic compound has a structure as shown in formula I: R2-X-R1-OH (formula I); wherein R1 is C2-C26 alkylenecarboxyacyl which contains one carboxyacyl group; R2 is selected from hydrogen, C1-C24 alkylcarboxyacyl / alkenylcarboxyacyl / alkyl / alkenyl, C6-C16 (aryl / heteroaryl / arylalkenyl / aralkyl / polyene)ylcarboxyacyl, C8-C18 aryl / arylalkenyl, dehydroxylated residue of C5-C45terpene alcohol, dehydroxylated residue of C20-C30 lipid-soluble vitamins, dehydroxylated residue of C18-C29 sterols, and carboxyacyl of C19-C26 carboxyl-containing steroids; -OH and the carboxyacyl residue of R1 are covalently linked to form carboxyl; and X is a linking group and covalently links to both R1 and R2. The present invention further relates to the use of the compound in the preparation of a chemically modified drug and in the promotion of transdermal absorption of drug molecules.