76 results about "Lipid soluble vitamins" patented technology

The invention discloses a method for detecting multiple lipid-soluble vitamins in a blood sample simultaneously. The method comprises the steps of preprocessing a biological sample by a simple liquid-liquid extraction method, then carrying out chromatographic separation and mass spectrometric detection, respectively selecting a pair of qualitative ions and a pair of quantitative ions according to each vitamin, wherein the relative retention time and qualitative ion pairs of the various vitamins are taken as qualitative basis, and a standard curve for quantitation is formed by standard substances. Meanwhile, according to the method, three levels of quality control substances are used for inspecting the accuracy and effectiveness of the method, and the distortion of the detection result is avoided. According to the method, the purpose that six lipid-soluble vitamins in one serum sample can be simultaneously detected can be realized for the first time by applying an LC-MS technology, the influence caused by interferents can be alleviated, the operation is simple, convenient and rapid, the analysis time is only 4.8min, the throughput is high, the cost is low, the levels of lipid-soluble vitamins in a human body are effectively monitored, and the method has guiding significance on the reasonable and safe supplementation of vitamins, and is liable to clinical promotion and popularization.

The present invention relates to amino acid humanized infant formula milk powder and a preparation method thereof. The amino acid humanized infant formula milk powder comprises the following materials by a certain weight percent: lactose, demineralised whey powder, vegetable oil, skimmed milk powder, hydrolyzed whey protein, galactooligosaccharides, fructo oligosaccharide, a mineral premix, ARA, casein hydrolysate, whey protein concentrate, soybean phospholipids, DHA, a water-soluble vitamin premix, casein phosphopeptides, lactoferrin, L-tyrosine, nucleotide, a lipid soluble vitamin premix, L-tryptophan, L-methionine and taurine. The present invention also includes a method for preparing the amino acid humanized infant formula milk powder. The present invention can effectively solve the problem of pool protein absorption and digestion effect and the low protein utilization rate of infants during infant period.

The invention provides a method for preparing hydrophobic vitamin microcapsules, and relates to vitamin microcapsules. The method comprises the following steps: (1) adding an oil-phase core material in an agitating pan, and melting the oil-phase core material to prepare vitamin oil containing antioxidant, wherein the oil-phase core material comprises lipid-soluble vitamin, an antioxidant and other greases; (2) dissolving a wall material in water to prepare a water solution with solid content of 20-60wt% to obtain a water phase; (3) adding the vitamin oil containing antioxidant prepared in the step (1) into the water phase obtained in the step (2), and emulsifying and homogenizing to form uniform emulsion; (4) adding protein active enzyme into the emulsion prepared in the step (3), granulating, performing a crosslinking reaction, and drying to obtain the hydrophobic vitamin microcapsules. According to the method, other toxic or strong oxidizing chemical substances are not added, the prepared microcapsules are safer and more environment-friendly, has longer shelf life, and is high in embedding rate and low in surface oil, so that the microencapsulation efficiency can be further improved.

The invention discloses a composite vitamin immunopolysaccharide nano micro-emulsion for livestock and poultry. The micro-emulsion comprises the following raw materials: active ingredients, an emulsifier, a co-emulsifier and a solvent, wherein the active ingredients comprise the following components by weight parts: 8.3-21 parts of lipid-soluble vitamin, 45.5-67.3 parts of water-soluble vitamin, 1.1-10.2 parts of amino acid, 110-170 parts of immunopolysaccharide, 0.5-1.5 parts of an antioxidant and 3-8 parts of a preservative. The micro-emulsion provided by the invention has the characteristics that the emulsifier consumption is reduced, the use is convenient, double effects of improving immunity, disease resistance and nutrient uptake of the livestock and poultry are achieved, the loss in a processing process is low and the properties in a storage process are stable. The invention further provides a preparation method and application of the composite vitamin immunopolysaccharide nano micro-emulsion for livestock.

The invention comprises compounds, methods of making, and methods of using. A group of polymer-cyclodextrin-lipid conjugates having a center backbone and three or four appended functional groups are disclosed, wherein one of the hydrophilic components is cyclodextrin. The compounds may have a backbone with three or four appended functional groups: one or two lipophilic compounds including sterols or “fat soluble” vitamins or fatty acids, one or two hydrophilic polymer and one cyclodextrin. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the center backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

The invention discloses a functional liquid vitamin premix and a preparation method thereof. The functional liquid vitamin premix is prepared from an emulsifying agent, an auxiliary emulsifying agent, a stabilizing agent, liposoluble vitamin, water soluble vitamin, chitosan oligosaccharide, glucose oxidase, threonine, tryptophan and water. The preparation method comprises the following steps of: adding the liposoluble vitamin into the emulsifying agent and the auxiliary emulsifying agent to obtain solution A; adding the water soluble vitamin into water to obtain solution B; adding the chitosan oligosaccharide, the glucose oxidase, the threonine and the tryptophan into water and then adding the stabilizing agent dissolved into water to obtain solution C; adding water into the solution A toobtain solution D; adding the solution B and the solution C into the solution D, so that the volume of the solution reaches 1 liter or the volume of the solution reaches 1 liter by supplementing water; and filtering by using a filter membrane with the thickness of 0.45 mu m to perform degerming. The functional liquid vitamin premix prepared by the method is clear and transparent, has high stability, can be mixed with water according to any ratio, can supplement vitamin and amino acid required by an organism quickly, can keep chicken intestinal tract healthy, enhance organism immunity, and improve growth and production properties of poultry comprehensively.

The invention relates to a weight reducing and fat reducing special type clinic nutrition recipe, which comprises 20 to 38 parts of protein, 8 to 12 parts of fat, 40 to 50 parts of carbohydrate, 5 to 8 parts of dietary fiber, 0.3 to 1.5 parts of macro elements, 0.01 to 0.04 part of trace elements, 0.005 to 0.015 part of lipid-soluble vitamin, 0.01 to 0.3 part of water-soluble vitamin, 0.05 to 1 part of dietary essence, 0.1 to 2 parts of medical and edible ingredients, 0.1 to 3 parts of natural plant compounds and 0.005 to 2 parts of new resource food, wherein the medical and edible ingredients are selected from at least one of poria cocos, fructus lycii, lotus leaves, semen cassiae, radix platycodi, rhizoma dioscoreae, fructus crataegi and coix seeds; each ingredient is prepared into powder in advance; the fat and the vitamin are prepared into powder by using a micro-capsule embedding technology. Through the screening and the proportioning of the ingredients, the nutrition recipe provides reasonable and overall nutrition support for patients with adiposity; meanwhile, the medical and edible ingredients, the natural plant compounds and the new resource food with the effects of replenishing qi to invigorate the spleen, eliminating phlegm, removing dampness and reducing weight and fat are added, so that the effects of preventing and treating the adiposity are achieved.

The invention provides a method for simultaneously detecting multiple lipid-soluble vitamin contents in blood. The method comprises the following steps: detecting at least three standard solutions byutilizing a high-performance liquid chromatograph tandem mass spectrometer so as to obtain a corresponding chromatogram, wherein each standard solution contains multiple vitamins and internal standardsubstances thereof with known concentrations; fitting to obtain standard curve equations of various vitamins according to the concentration specific value of various vitamins and the internal standard substances thereof in the standard solutions, and the peak area specific value of the vitamin and the internal standard substance in the corresponding chromatogram; treating to-be-detected blood toobtain a blood sample, and adding multiple internal standard substances with known concentrations, and performing sample pre-treatment to obtain a to-be-detected sample; detecting the to-be-detected sample under the same detection condition to obtain the chromatogram thereof; substituting the peak area specific value of each vitamin and the internal standard substance thereof in the chromatogram into the corresponding standard curve equation, and computing the content of each vitamin in the to-be-detected blood according to the concentration of the added internal standard substances thereof. Through the method provided by the invention, the contents of various lipid-soluble vitamin contents in the blood can be detected at the same time.

The invention relates to a detection method for the content of lipid-soluble vitamins. The detection method comprises the steps that a classical pretreatment mode of a saponification reaction is adopted, but traditional liquid-liquid extraction is replaced with ultrasonic extraction, and a to-be-detected solution and a standard solution are obtained through pretreatment; the standard solution and the to-be-detected solution are detected through liquid chromatography to obtain the retention time and the peak area of all components in a lipid-soluble vitamin standard substance and all components in to-be-detected feed, and a corresponding curve of the concentration and the peak area of the lipid-soluble vitamin standard substance is drawn; the retention time and the peak area of all the components of the to-be-detected feed are compared with a standard curve, and the content of the lipid-soluble vitamins in the to-be-detected feed is calculated. Compared with the prior art, the detection method has the advantages that the pretreatment process is simple, the usage amount of poisonous and harmful petroleum ether is decreased, and the method is more environmentally friendly and safer; in addition, a detection result is high in precision, the effect is good, and simultaneous separation and detection on the vitamin A, the vitamin D3 and the vitamin E are achieved in a short time.

The present invention relates to an improved somatotropin composition consisting of somatotropin having in vivo, at least one of lipid-soluble vitamins and at least one of pharmaceutically acceptable lubricants, which improves poor syringeability under cold temperature which has been a defect of the conventional somatotropin formulation using vitamins, and which shows at least the equivalent effect to that of the conventional formulation.

The invention discloses a bottled grease micro emulsion freeze-dried preparation with 13 composite vitamins. The preparation is prepared by wrapping lipid-soluble vitamins A, D, E and K in grease micro emulsion of which the particle size is smaller than 120nm, mixing with water-soluble vitamins B and C, folic acid, nicotinamide and the like, adding a freeze-drying forming agent and a redissolution additive, and freeze-drying. The novel freeze-dried preparation, which contains 13 vitamins and is developed according to the above formula and the preparation method, is simple in process, the stability of the vitamins can be improved, and the side effect caused by medicine decomposition and decomposition products is alleviated; the problem of codissolution of lipid-soluble vitamins and water-soluble vitamins is effectively solved, sufficient dissolution of medicine compounds is ensured, and the side effect of undissolved substances on human bodies is avoided.

Saponin (quillaja and yucca) and terpenoid (mono- and di-) botanicals are used for emulsion-based lipids to produce stable nanoparticles of the active nutrients or pharmaceuticals by reducing surfactant usage (less than 5%) and by reducing particle size (less than 600 nm). Non-synthetic emulsion-based formulations enhance bioavailability and mitigate safety concerns. This nanoemulsion technology is suitable for oil-in-water ingredients including vitamin E tocotrienols, CoQ10s, curcuma terpenoids, symmetrical carotenoids, phenolics, lipid-soluble vitamins, and lipid-soluble pharmaceuticals.

The invention discloses a preparation method of corn peptide glycosylation product nano particles embedding lipid-soluble vitamins. The method comprises the following steps: firstly dissolving a corn peptide and a polysaccharide into a phosphate buffer respectively, mixing the corn peptide solution with the polysaccharide solution, then freeze-drying the mixture, and putting the obtained dry powder in a closed dryer to carry out dry hot reaction at 55-65 DEG C for 4-7 days; obtaining a corn peptide glycosylation product; then adding the corn peptide glycosylation product to water, stirring the solution fully, and adjusting the pH value; dropwise adding a lipid-soluble vitamin ethanol solution, stirring the solution fully, and carrying out rotary evaporation, thus obtaining the corn peptide glycosylation product nano particles embedding lipid-soluble vitamins. The preparation method has the advantages and beneficial effects that the corn peptide glycosylation product nano particles embedding lipid-soluble vitamins have high lipid-soluble vitamin embedding rates and small particle sizes; the solution has better transparency and pH stability; the corn peptide glycosylation product nano particles can be applied to dairy products and drinks as ingredients; the method is simple in process, low in cost and strong in operability.

The invention relates to a medicinal composition of a liposoluble vitamin injection (I) and a water-soluble vitamin for injection, in particular to a combined application package. The medicinal composition contains the liposoluble vitamin injection (I) and the water-soluble vitamin for injection. When in use, the medicinal composition is dissolved or diluted by using water for injection or glucose injection firstly, and then is subjected to intravenous drip respectively. In the combined application package, vitamins required by a human body are comprehensively implemented, the defect caused by using a single vitamin is overcome, and the treatment effect is greatly improved.

The invention belongs to the technical field of chemical ingredient detection, and particularly relates to a method for detecting multiple kinds of vitamin simultaneously. According to the detecting method, multiple lipid-soluble vitamin samples contained in a sample can be fast and accurately measured simultaneously through a two-dimensional liquid chromatographic analysis method. According to the method, effluent in a specific period of a one-dimensional chromatographic column is injected to a two-dimensional chromatographic column, effluent of the two-dimensional chromatographic column is subjected to vitamin D measurement, the other effluent of the one-dimensional chromatographic column is subjected to measurement of non-vitamin D lipid-soluble vitamin, peakoverlap of vitamin D and other lipid-soluble vitamin can be avoided, and the influence of lipid matter in the sample on the detection accuracy of vitamin D is effectively reduced. According to the detecting method, the normal-phase column purifying process on vitamin D in a traditional method can be omitted, tedious detecting steps are simplified, detection time is saved, and high accuracy can be guaranteed.

The invention comprises compounds, methods of making, and methods of using. The compounds may have a linear or cylic backbone and three or four appended functional groups: one or two lipohilic compounds including sterols or "fat soluble" vitamins, one or two hydrophilic polymer, and one or two carbohydrate. A group of polymer-carbohydrate conjugates having a central backbone and three appended functional groups are disclosed whereinone lipophilic compound is void of both steroid acids. The conjugate may have fatty acids as the primary lipophilic carrier, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

The invention discloses edible oil. The edible oil is characterized in that the formula of the edible oil comprises the following components in part by weight: 80-100 parts of olive oil, 46-60 parts of sunflower seed oil, 10-14 parts of arochidonic acid oil, 2-5 parts of taurine components, 3-4 parts of DHA components, 0.7-1.2 parts of EPA components, 0.2-0.4 part of zinc-enriched yeast, 0.1-0.2 part of selenium supplement ingredients, 2-2.3 parts of hemerythrin, 1.1-1.3 parts of hemocyanin, 3-4 parts of nutritious protein components, 3-6 parts of lipid-soluble vitamin, 2-4 parts of antioxidants and 2.2-4.1 parts of emulsifiers. The edible oil disclosed by the invention has the advantages that an iron supplement agent can be added to the oil environment because the hemerythrin is added as a carrier of iron; a human body can obtain the needed copper element on the one hand and the copper element can also promote the absorption of the iron on the other hand because the hemocyanin is added as a copper supplement agent; and the edible oil can also have multiple other health care effects.

The invention relates to a pharmaceutical composition comprising lipid-soluble vitamin for injection, which improves water solubility, and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises vitamin A palmitate, vitamin D2, vitamin E, vitamin K1, water-soluble carboxylation chitosan and mannite. The preparation method comprises the steps of medicine liquid preparation, activated carbon adsorption, decarburization, filtering sterilization, filling, freeze-drying and the like. The pharmaceutical composition comprising lipid-soluble vitamin for injection utilizes the water-soluble carboxylation chitosan as a solubilizer, and has the advantages of few accessories, good water solubility, stable and controllable quality, high safety, simple preparation method, easiness in industrialization and the like.

A composite vitamin ADE oil injection for veterinary use and a preparing method thereof are disclosed. Each 100 mL of the injection comprises 5 million IU to 15 million IU of vitamin A palmitate, 100 thousand IU to 800 thousand IU of vitamin D3, 1-5 g of vitamin E acetate and 0.01-0.1 g of butylated hydroxyanisole, with the balance being oil used for injections. In normal shelf life, the injection keeps a clear state and is free of turbidness, layering and other instable phenomena. Lipid-soluble vitamins are prepared into the oil injection that is good in stability, and therefore difficult problems of dissolving the lipid-soluble vitamins and keeping a clear solution state are overcome.

The present invention describes a formulation comprising a prune and / or plum concentrate, and one or more water-soluble, non-digestible, prebiotic oligosaccharides. Optionally, one or more low calorie sweeteners, an antioxidant, calcium sennosides, or sennosides extract, PEG-3350, licorice, cocoa, coffee, tea flavors; fruit flavorings and spice flavorings, gelatin, agar-agar, carrageenan, pectin or cocoa powder are added. Other ingredients may be present as dietary supplements such as water-soluble vitamins, lipid-soluble vitamins; amino acids, maltodextrin, resveratrol, caffeine, mineral supplements, or natural sleep aids for use as a laxative, A variety of formulations are possible, such as premix, a laxative+energy power drink or power bar, or as a prebiotic supplement in probiotic yogurts, or in the form of gummies, chocolates, candies, and desserts such as red beans Japanese desserts. These present formulations are improved for taste, fast acting, portable and palatable laxatives, and as dietary supplements.

The invention discloses a liquid chromatography-tandem mass spectrometry detection method for a plurality of lipid-soluble vitamins in dried blood spots. The method comprises the following steps: preparing 1 to 3 blood stain samples, placing the 1 to 3 blood stain samples in a centrifugal tube, adding first extraction liquid, and performing vortex treatment for 25 to 35 minutes; adding an internalstandard solution and second extraction liquid, and performing vortex treatment for 2 to 4 minutes; centrifuging the mixture, transferring a supernatant into another centrifugal tube, performing blowdrying with nitrogen gas, adding reconstitution fluid, performing vortex treatment for 2 to 3 minutes, and sampling the reconstitution fluid for analysis; injecting a dry blood spot sample solution prepared in the step (1) into a LC-MS / MS (Liquid Chromatograph-Tandem Mass Spectrometer), and recording a chromatogram; and acquiring the retention time and mass spectrum data of the plurality of lipid-soluble vitamins. The detection method has the advantages of easiness, sensitivity, rapidness, accuracy, high specificity and high repeatability, and can be used for detecting the plurality of lipid-soluble vitamins in the dried blood spots.

The invention refers to a blood processing hollow fiber membrane, a blood purifier and a manufacturing method thereof. The subject aims to obtain a blood processing hollow fiber membrane which maintain oxidation resistance under harsh environment such as high temperature preservation and change less due to lipid-soluble vitamin. The blood processing hollow fiber membrane comprises A-D; the surface of the blood processing hollow fiber membrane contains, calculating by membrane area, lipid-soluble vitamin in a scope above 10 mg / m2 and below 300 mg / m2; the content of the lipid-soluble vitamin on the surface of the blood processing hollow fiber membrane is over 50 mass % of the whole content of the lipid-soluble vitamin of a blood processing hollow fiber membrane, wherein A is polyether sulfone resin, B is hydrophilic polymer, C is lipid-soluble vitamin and D is ketone and / or alcohol with less than four carbons.

The invention provides a serum-free insect cell culture medium and a preparation method and application thereof. The serum-free insect cell culture medium is prepared from basic components, protein components, lipid components and auxiliaries, wherein the basic components include, by weight, 9-14 parts of inorganic salt, 3.3-5 parts of amino acid or salt, 0.17-0.26 part of water soluble vitamins, 0.0016-0.0024 part of hormones and 0.0024-0.0036 part of microelements; the protein components include, by weight, 1.6-2.4 parts of animal protein hydrolysate, 2.4-3.6 parts of plant protein hydrolysate and 2.4-3.6 parts of a yeast extract; the lipid components include, by weight, 0.14-0.22 part of fatty acid, 0.028-0.042 part of lipid-soluble vitamins and 0.24-0.36 part of cholesterol; the auxiliaries include, by weight, 7.2-10.8 parts of a defoaming agent and 2.6-4 parts of a surface active agent. The serum-free insect cell culture medium is low in cost, good in long-term storage stability, high in cell density during insect cell culture and capable of achieving large-scale production and application easily.

The invention discloses a bamboo shoot fiber nutrition powder and a manufacturing method thereof. The nutrition powder is characterized by comprising corn flour, black rice flour, sesame powder, phospholipid and xylooligosaccharide, and further comprising bamboo shoot fiber powder, and the weight ratio is as follows: 30-40 parts of corn flour, 25-30 parts of black rice flour, 10-15 parts of sesame powder, 2-3 parts of phospholipid, 5-10 parts of xylooligosaccharide and 5-10 parts of bamboo shoot fiber powder. Compared with the prior art, the bamboo shoot nutrition powder has the following advantages of containing rich lipid-soluble vitamins E, protein, carbohydrate, vitamins B, calcium, phosphorus, potassium, magnesium, iron, zinc and other nutrient elements, low fat, low sugar, multiple fibers, enhancing immunity and regenerative capacity of human bodies, reducing a PH (potential of hydrogen) value of an intestinal tract and inhibiting growth of harmful germs.

The invention provides a special clinical nutrition formula of fatty acid metabolism disorder. The nutrition formula is characterized by comprising, by weight, 15-28 parts of protein, 8-12 parts of fat, 48-65 parts of carbohydrate, 3-6 parts of dietary fiber, 0.6-1.2 parts of macro-elements, 0.01-0.04 part of microelement, 0.005-0.03 part of lipid-soluble vitamin, 0.08-0.2 part of water soluble vitamin, 0.06-2 parts of medicinal and edible components, 0.02-3 parts of natural plant compounds and 0.02-2 parts of new resource food; the invention further provides a preparation method of the aboveclinical nutrition formula. The formula can supplement nutrition required by patients suffering from fatty acid metabolism disorder, improve multi-fat metabolism disorder, promote normal fat metabolism, relieve fat metabolism disorder symptoms, and relieve pain of patients.

The invention provides a complementary food nutrient supplementing food coating containing nuts for infants and children and relates to the technical field of complementary food nutrient supplementing foods for the infants and the children. The formula of the complementary food nutrient supplementing food coating contains following components in percentage by mass: 80-90% of nut jam, 6-8% of edible oil and / or DNA (Deoxyribose Nucleic Acid) algae oil, 0.05-0.1% of a multivitamin premix and 2-5% of a multi-mineral-substance premix, wherein the multivitamin premix comprises lipid-soluble vitamin and water soluble vitamin; the apparent viscosity of the coating is 20000-80000 centipoises and the content of fat is 8-40%. According to physiological functions of the infants and the children and a knowing and diet principle of growth and development, many vitamins and mineral substances which have high density are added into the nut jam and are used as the nutrient supplementing food for the infants and the children, so as to improve the nutrition and the health of the infants and the children.

The invention relates to a pharmaceutical composition of lipid-soluble vitamin and a preparation method thereof. The composition comprises the following ingredients: 0.30 to 1.50mg of vitamin A palmitate, 2 to 15mu g of vitamin D2, 3 to 12g of vitamin E3, 0.05 to 0.5mg of vitamin K1, 0.1 to 2g of injection soybean oil, 0.1 to 0.36g of injection lecithin, and 0.1 to 0.6g of glycerol. The preparation is an injection or freeze-dried powder injection. The pharmaceutical composition with multiple vitamins is strong in stability, and is suitable for clinical application.

The invention relates to a detection method for the content of lipid-soluble vitamins. The detection method comprises the steps that a classical pretreatment mode of a saponification reaction is adopted, but traditional liquid-liquid extraction is replaced with ultrasonic extraction, and a to-be-detected solution and a standard solution are obtained through pretreatment; the standard solution and the to-be-detected solution are detected through liquid chromatography to obtain the retention time and the peak area of all components in a lipid-soluble vitamin standard substance and all components in to-be-detected feed, and a corresponding curve of the concentration and the peak area of the lipid-soluble vitamin standard substance is drawn; the retention time and the peak area of all the components of the to-be-detected feed are compared with a standard curve, and the content of the lipid-soluble vitamins in the to-be-detected feed is calculated. Compared with the prior art, the detection method has the advantages that the pretreatment process is simple, the usage amount of poisonous and harmful petroleum ether is decreased, and the method is more environmentally friendly and safer; in addition, a detection result is high in precision, the effect is good, and simultaneous separation and detection on the vitamin A, the vitamin D3 and the vitamin E are achieved in a short time.