The invention provides a high survival and life-saving inflatable boat with the function of protecting against a shark attack. The boat structurally comprises an air cushion outer layer, sixteen grips, a waterproof chain, sixteen stay buckles, a shark attack preventing manual control device, a stay handle and a ventilation board; the grips are fixedly installed on the top of the air cushion outerlayer, the waterproof chain is fixedly installed on the top face of the air cushion outer layer, and the stay buckles are embedded into an outer ring of the top of the shark preventing manual controldevice. Accordingly, due to the fact that a shark attack preventing frame extending drawing charging cylinder can control manual starting of an extending shark preventing safe mechanism, a shark preventing extending knife ball rack mechanism is made to stretch to be of a spheroid-like structure from a flat state so as to wrap the life-saving boat, the unfolded knife rack is provided with a knife pivot and a three-edged cavity machete controlled by the same, strike and bite of a shark can be effectively dealt with, and then a survivor can keep himself / herself safe even though he / she is attackedby sharks in the process of floating on the sea to wait for rescue.