Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
41results about How to "Improve antithrombotic properties" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Heart valve prosthesis
ActiveUS20100023121A1Restrict blood backflowPreventing possibility of generationHeart valvesBone implantBlood flowThrombus
A medical device in cardiac surgery for replacement of the diseased native heart valves in humans increases thromboresistance of heart valve prosthesis. A heart valve prosthesis comprising an annular housing with the inner surface defining the blood flow I through the valve prosthesis and leaflets mounted within the annular housing with the possibility to pivot around the reference axis between an open position which allows the passage of the direct blood flow I, and a closed position which restricts the blood backflow II. Each leaflet has an upstream surface facing the direct blood surface I, a downstream surface facing the blood backflow II, a coaptation surface, and a side surface. Console projections radially oriented are provided at the inner surface of the housing, and each leaflet has a slot which corresponds to the projection. The inner surface of the housing is mainly cylindrical, and the downstream surface of each leaflet is in the form of the crossing cylindrical and conical surfaces. The upstream surface of each leaflet is in the form of the cylindrical surface. Higher thromboresistance of the heart valve prosthesis is achieved through elimination of the elements which introduce disturbances into the blood flow and reduction of the number of hinged joints.
Owner:MEDENG
Medical device and method for producing the same
ActiveUS20110027757A1Good antithrombotic propertiesImprove concentrationDental implantsImpression capsAdhesion processPhosphorylcholine
An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
Owner:KYOCERA CORP +1
Medical material and hollow fiber membrane module
ActiveUS20130306544A1Improve antithrombotic propertiesMembrane performance is stableSemi-permeable membranesMembranesHollow fibre membraneParticulates
The present invention provides a medical material and a blood purification apparatus each having high anti-thrombotic properties and high safety. The apparatus is produced by incorporating therein a medical material which has a hydrophilic copolymerization polymer present on a surface thereof which is to be in contact with blood, wherein particulate protuberances each having a particle diameter of 50 nm or more are present on the surface which is to be in contact with blood at a density of 3 particles / μm2 or less and the relaxation time of adsorbed water in the hydrophilic copolymerization polymer is 2.5×10−8 seconds or shorter and 5.0×10−10 seconds or longer at −40° C.
Owner:TORAY IND INC
Chinese medicine effective part composition for supplementing qi and recovering pulse
InactiveCN1899352AImprove microcirculationLong-lasting microcirculationMetabolism disorderAntineoplastic agentsDiabetes mellitusCoronary heart disease
The present invention discloses a kind of Chinese medicine composition of effective components for supplementing qi and restoring pulse, and belongs to the field of medicine preparing technology. The medicine composition is prepared with total ginsenoside and total dogwood glycoside in certain weight ratio. The medicine composition has the functions of invigorating primodial qi, astringing qi, restoring pulse, etc. and is suitable for treating shock caused by different causes, multiple organ failure, coronary heart disease, etc.
Owner:罗益民
Block copolymer and antithrombotic coating agent
ActiveUS20140235748A1Improve balanceImprove solubilityPharmaceutical containersDead animal preservationPolymer scienceMeth-
The object of the present invention is achieved by providing a copolymer, in particular, a block copolymer which has excellent coating formation ability, adhesive properties to a substrate, and does not adsorb protein; an antithrombotic coating agent which has superior antithrombotic properties and adhesive properties to a substrate to those of the conventional antithrombotic coating agent; and a medical instrument which is obtained by coating the antithrombotic coating agent, and the block copolymer includes a polymer (A) containing a (meth)acrylic ester monomer and a polymer (B) containing a (meth)acrylamide monomer and has excellent coating formation ability and high adhesive properties to a substrate.
Owner:KAWAMURA INST OF CHEM RES +1
Gluconic acid modified chitosan nucleophilic NO donator and synthesizing method thereof
InactiveCN101195031APromote healingImprove antithrombotic propertiesPharmaceutical non-active ingredientsCardiovascular disorderO carboxymethyl chitosanSodium methoxide
A gluconic acid modified chitosan nucleophilic NO donor and synthesizing method belongs to the medicine engineering technical field. The invention modifies the carboxylation reaction to NH2 group on chitosan or O-carboxymethyl chitosan for leading the NH2 group to produce nucleophilic NH group which can react with NO. Secondary amine NH group on gluconic acid modified chitosan or O-carboxymethyl chitosan molecules carries out reaction in a methanol solution of sodium methoxide with NO gas molecules, wherein, Na+ / NH=2, the [N(O)NO]- group is produced, and the molecular structural formula of the achieved gluconic acid modified chitosan or O-carboxymethyl chitosan nucleophilic NO donor is as follows.s The nucleophilic NO donor of the invention has different NO release speeds and larger load capacity, can simultaneously overcome cytotoxicity of nucleophilic reagent (polyamines) and avoid from producing oncogenicity coproduct of nitrosamine, and has a certain targeting capacity. R=H, CH2COONa.
Owner:SHANGHAI JIAO TONG UNIV
Ocean Sipunculus nudus plasmin and its preparation and application
InactiveCN103382463AImprove microcirculationAvoid damagePeptide/protein ingredientsEnzymesPlasminMarine invertebrates
The invention relates to an ocean invertebrate plasmin which is a protein obtained by steps of homogenizing an ocean Sipunculus nudus digestive gland fluid, filtering to remove grease, freeze-drying, salting-out, desalinizing and carrying out DEAE chromatography and gel filtration chromatography. Amino acid sequence of the N-terminal part is Seq.2, and molecular weight is 15 KDa. It proves through experiment research that the plasmin has good effects of resisting thrombus and preventing and curing stroke.
Owner:许瑞安
Medical semi-maglev centrifugal pump based on steel ball
ActiveCN104373356APrevent leakageAvoid pollutionSpecific fluid pumpsPump componentsEngineeringMagnet
The invention relates to a medical semi-maglev centrifugal pump based on a steel ball. The centrifugal pump comprises a motor, a driving magnet ring and a driven magnet ring, wherein the driving magnet ring is connected with a motor rotor, and the driven magnet ring is arranged in the manner of not making contact with the driving magnet ring and transmits torque through magnetic force. An isolation seal cartridge is arranged in an air gap between the driving magnet ring and the driven magnet ring. The driven magnet ring and an impeller rotor are fixedly connected together. The impeller rotor is supported through a driven side base in the radial direction and limited through the steel ball in the axial direction in a unidirectional mode. The impeller rotor presses against the steel ball through an upper ejecting block, the steel ball is arranged on the driven side base, and the lower end of the steel ball presses against a pump case base through a lower ejecting block. By the adoption of the technical scheme, compared with a general sliding bearing, mechanical friction contact is reduced, heat productivity is also reduced, and therefore the antithrombotic ability of a blood pump can be improved.
Owner:SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
Plasma film coating apparatus for particle surface modification
InactiveCN101294279AImprove surface performance Adsorption performanceImprove hydrophilicityChemical vapor deposition coatingMicrometerPlasma coating
The invention relates to a plasma coating device used for particle surface modification, which comprises a reaction chamber, a radio-frequency power supply, a monomer steam generating bottle, a dielectric gas bottle and a vacuum pump; the monomer steam generating bottle, the dielectric gas bottle and the vacuum pump are respectively connected with the reaction chamber through a pipeline, the radio-frequency power supply is connected with a radio-frequency discharge coil, and the radio-frequency discharge coil is wound on the outer wall of the container of the reaction chamber. The plasma coating device has the advantages that evenly controllable plasma coating on the particle surface can be realized; the components of the thin film are diversified; the thickness of the thin film is controllable between a few nanometers and a few micrometers; the thin film is of continuity, has no pinhole and can adopt a three-dimensional crosslinked way; specific thin film can be coated on the surface of the special particle.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
DGAT1 Inhibitor and Preparation Method and Use Thereof
ActiveUS20160272651A1Improve performanceLow cytotoxicityOrganic active ingredientsOrganic chemistryHypertriglyceridemiaFamilial hyperchylomicronemia
The present invention discloses a novel DGAT1 inhibitor, especially the compound of formula (I) or a pharmaceutically acceptable salt thereof, preparation and pharmaceutical composition thereof, as well as their uses in the preparation of a medicament for the prevention and treatment of Familial hyperchylomicronemia (FCS), obesity, hyperlipoproteinemia or hypertriglyceridemia.
Owner:QINGDAO HUANGHAI PHARM CO LTD
Medical device and method for producing the same
ActiveUS9216241B2Improve antithrombotic propertiesAvoid depositionDental implantsImpression capsAdhesion processSilicon dioxide
An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
Owner:KYOCERA CORP +1
Folic acid modification of chitosan nucleophilic NO donator and compounding method thereof
InactiveCN101224305AChemically stableLong release half-lifePharmaceutical non-active ingredientsHalf-lifeCytotoxicity
The invention relates to a folic acid modified chitosan nucleophilic NO donor and a synthetic method for the folic acid modified chitosan NO donor and belongs to the field of medical engineering technology. The invention makes acylation modification to NH2 group on the chitosan to lead the NH2 to generate nucleophilic NH group which can react with NO; a secondary amine NH group on a folic acid modified chitosan molecule reacts with NO air molecules in methanol solution of sodium methylate to generate an (N(O)NO) <minus> group, and Na <plus> / NH is equal to 2 and a molecular structural formula of the obtained folic acid modified chitosan Nitric Oxide donor is provided. The nucleophilic NO donor of the invention provided with different NO release rates and longer half-life periods can overcome the weak points of non-specificity and targeting of the NO release, improve the utilization efficiency of NO and at the same time, the invention can overcome the cytotoxicity of nucleophilic agents (polyamines) and prevent the generation of carcinogenic by-product nitrosamine.
Owner:SHANGHAI JIAO TONG UNIV
Heart valve prosthesis
ActiveUS9095429B2Improve antithrombotic propertiesRestrict the blood backflowHeart valvesThrombusHeart operations
A medical device in cardiac surgery for replacement of the diseased native heart valves in humans increases thromboresistance of heart valve prosthesis. A heart valve prosthesis comprising an annular housing with the inner surface defining the blood flow I through the valve prosthesis and leaflets mounted within the annular housing with the possibility to pivot around the reference axis between an open position which allows the passage of the direct blood flow I, and a closed position which restricts the blood backflow II. Each leaflet has an upstream surface facing the direct blood surface I, a downstream surface facing the blood backflow II, a coaptation surface, and a side surface.
Owner:MEDENG
Medical mechanical micro-power pump for treating cardiovascular disease
InactiveCN104740704ASimple ingredientsImprove antithrombotic propertiesBlood pumpsIntravenous devicesImpellerHemolysis
The invention provides a medical mechanical micro-power pump for treating cardiovascular disease. The medial mechanical micro-power pump comprises a pump body, and an impeller mounted in the pump body, wherein the impeller comprises a casting titanium alloy impeller body, and a zirconium oxide ceramic material layer at the outside of the impeller body; the pump body comprises a casting titanium alloy pump, a titanium nitride ceramic material layer on the outer surface of the pump body, and a titanium carbide ceramic material layer on the inner surface of the pump body. According to the medial mechanical micro-power pump, the zirconium oxide ceramic material layer coats the surface of the pump body according to the type and speed of the impeller in contact with human cells, so that the anti-hemolysis performance and antithrombus and other performances of the material can be improved.
Owner:傅风荣
Tetrahydro-beta-carbolinyl-3- formyl-diethylenetriamino-beta-cyclodextrin copper complex, and preparation, antithrombotic action and application thereof
InactiveCN103446589AGood water solubilityImprove antithrombotic propertiesPharmaceutical non-active ingredientsBlood disorderIn vivoBioavailability
The invention discloses complexes formed by 6-[(1,2,3,4-tetrahydro-beta-carbolinyl-3)-formacyl-diethylenetriamino]-6-desoxy-beta-cyclodextrin (formed by connecting tetrahydro-beta-carbolinylcarboxylic acid to cyclodextrin by using diethylenetriamine as a connecting arm) and copper and a preparation method thereof. The invention further discloses favorable in-vivo antithrombotic activity and in-vitro vasodilatation action of the copper complexes. The invention provides excellent candidate compounds for developing medicines with high bioavailability and strong antithrombotic activity.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Medical intracardiac pump device
InactiveCN104857583ASimple ingredientsGood compatibilityBlood pumpsIntravenous devicesImpellerOxide ceramic
The invention discloses a medical intracardiac pump device which comprises a pump body and an impeller mounted in the pump body, wherein the pump body comprises a cast titanium alloy pump body, a zirconia ceramic material layer on the outer surface of the pump body, and a titanium oxide ceramic material layer on the inner surface of the pump body; the impeller comprises a cast titanium alloy impeller body and a titanium carbide ceramic material layer on the outer surface of the cast titanium alloy impeller body. According to the situation that the pump body is in contact with different types of human body cells at different speeds, the inner surface and outer surface of the pump body are coated with the titanium oxide ceramic material layer and zirconia ceramic material layer respectively to improve the compatibility between the material and blood.
Owner:傅风荣
Preparation method and application of anticoagulant copolymer
ActiveCN113045695AImprove anticoagulationImproved resistance to protein adsorptionSurgeryPharmaceutical delivery mechanismPolymer scienceSide chain
The invention belongs to the technical field of medical treatment, and discloses a preparation method and application of an anticoagulant copolymer; the polymer is formed by adding and polymerizing a monomer A, a monomer B and a monomer C in proportion, the monomer A contains a double bond and a sulfonic acid group, the monomer B is a hydrophilic substance containing a double bond and a pyrrole ring, and the monomer C is a hydrophobic substance containing a double bond; and a pyrrole ring of a side chain of the polymer is opened, and vitamins and diosgenin are grafted through esterification reaction. The copolymer can be used for modifying the surface of a polyurethane material, and the modified polyurethane surface has good anticoagulation, anti-infection, anti-protein adsorption and anti-thrombus properties at the same time, and has a good application prospect.
Owner:WUHAN YONGSEN BIOTECH
Drug formulation containing fibrate medicament and process for producing the same
InactiveCN101534825AReduce the original concentrationReduce secretion abnormalitiesMetabolism disorderDigestive systemPitavastatinFibrinogen
A preparation (pharmaceutical composition) reducing a concentration of a free fatty acid and / or fibrinogen in the blood is prepared. The preparation contains a statin agent comprising at least a statin compound having a benzopyridine skeleton (e.g., pitavastatin) and a fibrate agent (e.g., fenofibrate). The preparation is useful as a preventive or treating agent for hyper-free fatty acidemia, metabolic syndrome, or type II diabetes.
Owner:ASKA PHARMACEUTICAL CO LTD
Composition for daily prevention and treatment of microthrombus and application
PendingCN112603994AImprove antithrombotic propertiesImprove antioxidant capacityPeptide/protein ingredientsGinkgophyta medical ingredientsAntioxidant capacityInflammatory factors
The invention belongs to the technical field of biological medicines, and particularly relates to a composition for daily prevention and treatment of microthrombus and application. The composition is prepared from the following substances in parts by weight: earthworm protein, nattokinase and corn stigma in a weight ratio of (3-1): (3-1): (3-1). According to the invention, earthworm protein and nattokinase are utilized to directly dissolve fibrin in microthrombus or indirectly activate other plasmin so as to play a role in prevention and treatment; corn stigma is used for improving the antioxidant capacity of the body, reducing inflammatory factors and enhancing the antithrombotic effect of earthworm protein and nattokinase, and can remarkably dissolve microthrombus, improve old thrombus, reduce blood viscosity and improve the blood microenvironment.
Owner:陕西中鸿科瑞再生医学研究院有限公司
A kind of Tibetan medicine composition with antithrombotic effect
ActiveCN106913712BStrong antithrombotic effectImprove antithrombotic propertiesUnknown materialsBlood disorderMedicinal herbsFormulary
The invention discloses a Tibetan medicine composition with antithrombotic effect. On the basis of a traditional eight-medicine aquilaria wood pill, addition and deletion of medicinal materials in a prescription for the pill are carried out so as to allow the pill to have improved prevention and treatment effect on thrombotic diseases. Results of in-vitro and in-vivo antithrombotic experiments show that the traditional Tibetan eight-medicine aquilaria wood pill has strong antithrombotic effect after deletion of olibanum and travertine and presents substantially improved antithrombotic effect after further addition of long pepper, Chinese asafoetida and the dried heart of Bosgrunnien Linnaens, especially after addition of betel nut, and the improved antithrombotic effect is obviously better than the effect of the traditional eight-medicine aquilaria wood pill.
Owner:SHANDONG JINHE DRUG RES DEV
Compound preparation for treating thrombosis
InactiveCN106729678AIncreased serum half-lifeImprove antithrombotic propertiesHydrocarbon active ingredientsPeptide/protein ingredientsHalf-lifeApocynum venetum
Owner:JIESHOU JINGHUA TECH INFORMATION CONSULTING SERVICE CO LTD
Gluconic acid modified chitosan nucleophilic NO donator and synthesizing method thereof
InactiveCN101195031BPromote healingImprove antithrombotic propertiesPharmaceutical non-active ingredientsCardiovascular disorderO carboxymethyl chitosanSodium methoxide
A gluconic acid modified chitosan nucleophilic NO donor and synthesizing method belongs to the medicine engineering technical field. The invention modifies the carboxylation reaction to NH2 group on chitosan or O-carboxymethyl chitosan for leading the NH2 group to produce nucleophilic NH group which can react with NO. Secondary amine NH group on gluconic acid modified chitosan or O-carboxymethyl chitosan molecules carries out reaction in a methanol solution of sodium methoxide with NO gas molecules, wherein, Na<+> / NH=2, the [N(O)NO]<-> group is produced, and the molecular structural formula of the achieved gluconic acid modified chitosan or O-carboxymethyl chitosan nucleophilic NO donor is as follows. The nucleophilic NO donor of the invention has different NO release speeds and larger load capacity, can simultaneously overcome cytotoxicity of nucleophilic reagent (polyamines) and avoid from producing oncogenicity coproduct of nitrosamine, and has a certain targeting capacity.
Owner:SHANGHAI JIAO TONG UNIV
Artificial lung of membrane type
InactiveUS6967003B2Improve antithrombotic propertiesSemi-permeable membranesOther blood circulation devicesOxygenPermeation
A membrane artificial lung performs gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane. The membrane has a hollow fiber membrane of poly-4-methylpentene-1 and an oxygen permeation rate Q(O2) at 25° C. of from 1×10−6 to 3×10−3 (cm3(STP) / cm2·sec·cmHg) and an ethanol flux of from 0.1 to 100 ml / min·m2. The membrane has, in the side of the blood flow, a surface having an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative. The quaternary alkylammonium salts are a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.
Owner:DAINIPPON INK & CHEM INC +1
DGAT1 inhibitor and preparation method and use thereof
ActiveUS9809604B2Low cytotoxicityImprove antithrombotic propertiesOrganic active ingredientsOrganic chemistryHypertriglyceridemiaFamilial hyperchylomicronemia
The present invention discloses a novel DGAT1 inhibitor, especially the compound of formula (I) or a pharmaceutically acceptable salt thereof, preparation and pharmaceutical composition thereof, as well as their uses in the preparation of a medicament for the prevention and treatment of Familial hyperchylomicronemia (FCS), obesity, hyperlipoproteinemia or hypertriglyceridemia.
Owner:QINGDAO HUANGHAI PHARM CO LTD
Copolymer, antithrombotic coating agent using same and medical device
InactiveUS20190091380A1Efficient use ofExcellent film formation propertyPharmaceutical containersMedical packagingEthyl groupBiocompatibility
A biocompatible material, which has excellent film formation properties and resistance to water dissolution, and is easily applied on various bases as a coating, while having excellent antithrombotic properties, and to provide an antithrombotic coating agent and an antithrombotic coating film produced by using the biocompatible material, and a medical device provided with the antithrombotic coating film. A copolymer, containing at least one repeating unit (A) represented by formula (1) (wherein, n represents an integer of 2 to 10 and R1 represents a methyl group or an ethyl group), and at least one repeating unit (B) represented by formula (2) (wherein R2 represents an aliphatic hydrocarbon group); an antithrombotic coating agent containing the copolymer and an organic solvent; an antithrombotic coating film formed of the copolymer; and a medical device provided with the coating film.
Owner:MARUZEN PETROCHEMICAL CO LTD +1
Block copolymer and antithrombotic coating agent
ActiveUS9474835B2Improve solubilityGood dispersibilityPharmaceutical containersMedical packagingPolymer scienceCoating
The object of the present invention is achieved by providing a copolymer, in particular, a block copolymer which has excellent coating formation ability, adhesive properties to a substrate, and does not adsorb protein; an antithrombotic coating agent which has superior antithrombotic properties and adhesive properties to a substrate to those of the conventional antithrombotic coating agent; and a medical instrument which is obtained by coating the antithrombotic coating agent, and the block copolymer includes a polymer (A) containing a (meth)acrylic ester monomer and a polymer (B) containing a (meth)acrylamide monomer and has excellent coating formation ability and high adhesive properties to a substrate.
Owner:KAWAMURA INST OF CHEM RES +1
Chinese medicine effective part composition for supplementing qi and recovering pulse
InactiveCN1899352BImprove microcirculationLong-lasting microcirculationOrganic active ingredientsMetabolism disorderDiabetes mellitusCoronary heart disease
The present invention discloses a kind of Chinese medicine composition of effective components for supplementing qi and restoring pulse, and belongs to the field of medicine preparing technology. Themedicine composition is prepared with total ginsenoside and total dogwood glycoside in certain weight ratio. The medicine composition has the functions of invigorating primodial qi, astringing qi, restoring pulse, etc. and is suitable for treating shock caused by different causes, multiple organ failure, coronary heart disease, etc.
Owner:罗益民
Nucleophilic N0 donor of alkyl modified amido glucose, and synthetic method
This invention discloses a method for synthesizing alkyl-modified amino glucose as a nucleophilic NO donor. The method comprises: performing alkyl-modification on the NH2 groups of amino glucose to form nucleophilic NH groups, and reacting with NO molecules in sodium methoxide / methanol solution under 5 atm for 5 d to form [N(O)NO]- groups. The chemical formula of alkyl-modified amino glucose is shown in the formula. The obtained alkyl-modified amino glucose nucleophilic NO donor has different NO releasing rate and long half life, can overcome cytotoxicity of nucleophilic reagent and avoid the formation of oncogenic byproduct of nitrosamine, and have important clinical applications.
Owner:SHANGHAI JIAO TONG UNIV
Tetrahydro-beta-carbolinyl-3- formyl-diethylenetriamino-beta-cyclodextrin copper complex, and preparation, antithrombotic action and application thereof
InactiveCN103446589BGood water solubilityImprove antithrombotic propertiesPharmaceutical non-active ingredientsBlood disorderHydrogenDiethylenetriamine
The invention discloses complexes formed by 6-[(1,2,3,4-tetrahydro-beta-carbolinyl-3)-formacyl-diethylenetriamino]-6-desoxy-beta-cyclodextrin (formed by connecting tetrahydro-beta-carbolinylcarboxylic acid to cyclodextrin by using diethylenetriamine as a connecting arm) and copper and a preparation method thereof. The invention further discloses favorable in-vivo antithrombotic activity and in-vitro vasodilatation action of the copper complexes. The invention provides excellent candidate compounds for developing medicines with high bioavailability and strong antithrombotic activity.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Use of calcium metaphosphate as non-hard tissue engineering material
InactiveCN101357239BImprove adhesionImprove anticoagulationProsthesisHydroxybutyric acidCell adhesion
Owner:GUANGDONG GENERAL HOSPITAL
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com