2results about How to "Improve antithrombotic properties" patented technology

An outer skirt for a prosthetic heart valve is disclosed. As one example, a prosthetic heart valve may include an annular frame and an outer skirt disposed about an outer surface of the frame. The outer skirt may include: a first portion comprising a polymeric material; and a second portion comprising a fabric wherein the polymer material has a greater antithrombotic property than the fabric. The second portion is fixed to an inflow end of the frame and extends toward a middle portion of the frame, and the first portion extends from the second portion and toward an outflow end of the frame.

This invention relates to a recombinant hirudin fusion protein with collagen affinity, its preparation method, and its applications. The fusion protein is a recombinant hirudin fusion protein incorporating a collagen-binding domain (CBD). The fusion protein of this invention possesses affinity for type I and type III collagen, and can inhibit thrombin activity to exert an anticoagulant effect. Furthermore, it can bind well to collagen-based composite materials, making it suitable for use in cardiovascular implants such as heart valves, cardiac occluders, dialysis membranes, oxygenation membranes, artificial blood vessels, and vascular stents, as well as in extracorporeal circulation and blood purification devices, enhancing anticoagulant and antithrombotic effects.