4results about How to "Improve antithrombotic properties" patented technology

The invention relates to an acellular matrix material with biological functional activity and a preparation method thereof. The preparation method comprises the following steps: 1) providing an acellular matrix material subjected to crosslinking treatment; 2) reacting the crosslinked acellular matrix material with a biocompatible polymer, wherein the biocompatible polymer has a reactive group and a first subject and / or guest molecule; the reactive group is covalently bonded to a functional group on the acellular matrix material; and 3) reacting the acellular matrix material obtained in the step 2) with a second subject and / or guest molecule modified by a biological functional active substance through subject-guest interaction. Through the mode, the anti-calcification performance and the biological activity of the acellular matrix material can be improved at the same time, and the acellular matrix material is flexibly endowed with various biological function activities.

The invention belongs to the technical field of artificial blood vessels, and provides a composite modified double-layer structure small-caliber artificial blood vessel which comprises an inner layer and an outer layer, the inner layer comprises a mixture of zwitterionic polyurethane and polycaprolactone, the outer layer comprises polycaprolactone, zwitterionic polyurethane contains zwitterionic sulfonic acid negative ions and ammonium positive ions, and the zwitterionic sulfonic acid negative ions and the ammonium positive ions are different. Inner and outer layers of the artificial blood vessel are modified by heparin; the invention further provides a preparation method of the artificial blood vessel, the double-layer artificial blood vessel with a zwitterionic polyurethane and polycaprolactone blend as an inner layer and polycaprolactone as an outer layer is prepared through electrostatic spinning, and heparin is used for surface modification of the double-layer artificial blood vessel. The size of the small-caliber artificial blood vessel can be effectively controlled, and the prepared small-caliber antithrombotic artificial blood vessel has excellent biocompatibility, tensile property, protein adsorption resistance and antithrombotic property and can be used for vascular tissue repair or replacement.

An outer skirt for a prosthetic heart valve is disclosed. As one example, a prosthetic heart valve may include an annular frame and an outer skirt disposed about an outer surface of the frame. The outer skirt may include: a first portion comprising a polymeric material; and a second portion comprising a fabric wherein the polymer material has a greater antithrombotic property than the fabric. The second portion is fixed to an inflow end of the frame and extends toward a middle portion of the frame, and the first portion extends from the second portion and toward an outflow end of the frame.

This invention relates to a recombinant hirudin fusion protein with collagen affinity, its preparation method, and its applications. The fusion protein is a recombinant hirudin fusion protein incorporating a collagen-binding domain (CBD). The fusion protein of this invention possesses affinity for type I and type III collagen, and can inhibit thrombin activity to exert an anticoagulant effect. Furthermore, it can bind well to collagen-based composite materials, making it suitable for use in cardiovascular implants such as heart valves, cardiac occluders, dialysis membranes, oxygenation membranes, artificial blood vessels, and vascular stents, as well as in extracorporeal circulation and blood purification devices, enhancing anticoagulant and antithrombotic effects.