Method for preparing radioactive nuclide magnetic microsphere used in vivo

A radionuclide and magnetic microsphere technology, applied in the field of magnetic materials, can solve the problems of large tissue damage, high radiation dose, and radionuclide troubles in clinical applications, and achieve the effect of solving rejection reactions

Inactive Publication Date: 2007-10-03
北京倍爱康生物技术有限公司
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  • Abstract
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Problems solved by technology

However, internal radiotherapy has not yet found an ideal path, and problems such as the accurate positioning and administration of target tissues and the diffusion of radionuclides have been plagued by clinical applications.
3) External irradiation therapy: widely used, but the facilities are expensive and technically difficult
The radiation dose is large, and normal tissue damage is large

Method used

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  • Method for preparing radioactive nuclide magnetic microsphere used in vivo

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Embodiment Construction

[0014] 1. Weigh 2700g of ferric chloride, 0.5g of ferric chloride, and 0.1g of aluminum nitrate to make a solution. After being filled with nitrogen for storage, add ammonia water dropwise and stir at room temperature at a speed of 2000rpm. After adding 10ml of ammonia water dropwise, heat up to Stir at the same speed at 75°C, react for 90 minutes, then add oleic acid to disperse it, and wash with purified water to obtain magnetic ferric oxide particles.

[0015] 2. Weigh 2g ferric oxide particles, add 20ml styrene, 6ml divinylbenzene, 0.3g benzoic acid peroxide, add each component separately, ultrasonically disperse for 90 minutes, adjust the pH to 11.0, and incubate at 67°C , mix, add 1ml of methacrylic acid, 5ml of potassium persulfate solution, and dilute to 1001 with pure flower water. Add 0.18 g of sodium dodecylbenzenesulfonate and 0.5 g of emulsifier toluene cellulose ether into 100 ml of aqueous solution, and stir at 500 rpm. Magnetic microspheres were prepared after...

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Abstract

The invention provides a method for preparing radioactive nuclide magnetic microsphere used in vivo for the treatment of vessel embolism and tumor, wherein the process by the invention comprises the steps of, preparing magnetic ferrosic oxide particles, preparing magnetic microballoons, marking protein #+[131] and preparing radioactive nuclide. The invention solves the problems of rejection reaction of heterology antibody and damage of normal tissues.

Description

technical field [0001] The invention belongs to the technical field of magnetic materials, and in particular provides a preparation method of radionuclide magnetic microspheres used in vivo, which are used for tumor blood vessel embolization and tumor treatment. Background technique [0002] Magnetic microspheres are composed of iron ferric oxide or ferric oxide of a single configuration, covered with polymer materials, and coupled with various biological macromolecules on the outside of the polymer, such as monoclonal antibodies, which are immune Microspheres. The use of magnetic microspheres in biological separation began in the 1970s, and is currently widely used in cell separation, protein separation and purification, nucleic acid separation, antibiotics, and microbial separation. In recent years, many researchers have devoted themselves to using magnetic microspheres as new carriers for targeted drug delivery, especially in tumor drugs, which have broad application pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02A61K9/14C01G49/08A61P35/00
Inventor 刘振世幺崇正张玉庆
Owner 北京倍爱康生物技术有限公司
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