Supercritical impact flow method for wrapping micro granule

A supercritical and impinging flow technology, applied in the field of material engineering, can solve the problem of difficult fluidization of particles

Inactive Publication Date: 2007-11-28
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of this invention is to provide a kind of supercritical impinging flow particle coating method, this method can effectively combine existing supercritical fluidized bed coating method and impinging flow technology, make full use of both advantages separately, thereby Solve the problem that the existing fluidized bed coating method is difficult to fluidize when the particles are small

Method used

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  • Supercritical impact flow method for wrapping micro granule

Examples

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Embodiment Construction

[0012] The coated wall material and coated particles are added to the dissolution mixer 3 through the feeding port 10, and the CO in the storage tank 1 2 After the pressure is boosted by the high-pressure diaphragm pump 2, it is added to the dissolution mixer 3, and the temperature of the dissolution mixer 3 is raised by the constant temperature bath 4, so that the coating wall material is dissolved in supercritical CO 2 A solution is formed in the solution, and the coated particles are uniformly dispersed in the solution to form a suspension by stirring; the suspension is sprayed into the coating device 5 through a pair of coaxial nozzles 6 to form a collision flow; dissolved in the supercritical CO 2 The coated wall material in the solution is separated out from the solution rapidly due to the great supersaturation caused by the expansion and decompression of the solution through the nozzle 6, and is deposited on the surface of the coated particles to form a uniform skin lay...

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Abstract

The invention relates to a ultra-critical impact flow particle packing method, which is characterized in that: adding the wall material into the mixer to be dissolved into solution; mixing and dispersing the particle uniformly, to form suspension; using a couple of coaxial nozzles to output the wall material to be deposited on the surface of packed particle to form the coat, and separated by the separator to obtain the micro capsule product. The invention can combine the advantages of present packing fluid bed packing method and impact flow method, to be used in food industry, paper production, etc.

Description

technical field [0001] The invention belongs to the technical field of material engineering, relates to a preparation method of a microcapsule material, in particular to a supercritical impinging flow particle coating method. Background technique [0002] The drug microcapsule material can be prepared by using the drug as the core material and coating it with an appropriate wall material. Drug microcapsules have the functions of sustained release, controlled release, targeted drug delivery, immune isolation, etc., and can achieve timing, quantitative, and localized release, so as to prolong the drug delivery cycle, reduce the drug dose, reduce side effects, change the way of drug delivery, and improve The purpose of drug efficacy. [0003] In addition to the attractive application prospects in the field of medicine, microcapsules are also widely used in the fields of food, health products, pesticides, feed, coatings, textiles, printing and dyeing, papermaking and functional...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/04
Inventor 李志义
Owner DALIAN UNIV OF TECH
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