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Schizandrol dripping pills for decreasing aminopherase and method for preparing the same

The technology of ester dripping pills and alanine aminotransferase is applied in the directions of medical preparations containing active ingredients, pill delivery, pharmaceutical formulations, etc. level and other issues, to achieve the effect of benefiting labor protection and environmental protection, improving bioavailability, and drug safety

Inactive Publication Date: 2008-03-19
北京旷博生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] Now with several groups of specific examples, the preparation method of the five ester dripping pills of the present invention will be further described.

[0028] [Group 1: Trials with a single substrate]

[0029] 1. Drug raw material: Southern Schisandra Alcohol Extract

[0030] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0031] 3. Proportion: take g or kg as the unit, southern schisandra alcohol extract (calculated as schisandra ester A): matrix = 1:1 ~ 1:9;

[0032] 4. Prepare according to the process given in [Preparation Method] 4-7, and you can get five ester dripping pills of different specifications.

[0033] [test results]

[0034] Experiment 1: In order to observe the difference in quality of the five ester drop pills prepar...

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PUM

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Abstract

The invention discloses a schizandrol dripping pills for decreasing aminopherase and method for preparing. The objective of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, easy administration, low price, and causing no pollution during production. The drop pill is prepared from schizandrol concrete as raw material, and medicinal carrying agent as the base material.

Description

technical field [0001] The invention relates to a pharmaceutical composition capable of reducing serum alanine aminotransferase, which can be used for the treatment of patients with chronic and persistent hepatitis with elevated alanine aminotransferase, in particular to an oral preparation prepared from traditional Chinese medicine schisandra extract . Background technique [0002] According to the preparation method given in the national drug standard WS-10557 (ZD-0557)-2002, the five-ester tablet is a kind of tablet that can reduce serum alanine aminotransferase and can be used for chronic and persistent hepatitis with elevated alanine aminotransferase Oral tablets for the treatment of patients, clinically verified, definite curative effect, is a commonly used drug for clinical and family treatment of the above-mentioned diseases. [0003] The following is the formula, process and brief description given in the drug standard WS-10557 (ZD-0557)-2002: [0004] Prescriptio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/57A61P1/16A61P31/14
Inventor 曲韵智
Owner 北京旷博生物技术股份有限公司
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