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Externally applied transdermal Chinese medicinal formulation for treating skin cancer

A technology for transdermal preparations and skin cancer, which is applied in the field of external transdermal preparations of traditional Chinese medicines, can solve problems such as the external transdermal preparations of traditional Chinese medicines that have no curative effect on skin cancer, and achieves significant anti-tumor effect, definite curative effect, and the effect of inhibiting cell proliferation.

Inactive Publication Date: 2009-01-21
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no external transdermal preparation of traditional Chinese medicine with definite curative effect and convenient use in the treatment of skin cancer

Method used

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  • Externally applied transdermal Chinese medicinal formulation for treating skin cancer
  • Externally applied transdermal Chinese medicinal formulation for treating skin cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of Curcuma curcuma supercritical extract:

[0045] Weigh 8kg of Curcuma curcuma curcuma powder, put it in the extractor, start the high-pressure carbon dioxide pump, and maintain the pressure of the extractor and the flow rate of carbon dioxide at the set parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, that is, the extraction pressure is 19MPa, and the extraction flow rate is 4.8kg / m 2 ·s Adjust the temperature of the heating system according to the fluctuation of pressure and flow, maintain the temperature of the extractor at 50 ℃, keep the system stable, and reflux for 3 hours to obtain the supercritical extract of Curcuma curcuma curcuma with good fluidity and darker color.

Embodiment 2

[0047] Preparation of Curcuma curcuma supercritical extract:

[0048] Weigh 8kg of Curcuma curcuma curcuma crude powder, put it in the extractor, start the carbon dioxide high-pressure pump, and adjust the pressure of the extractor and the flow rate of carbon dioxide at the set parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, that is, the extraction pressure is 25MPa, and the extraction flow rate is 1.2kg / m 2 ·s; According to the fluctuation of pressure and flow, adjust the temperature of the heating system, maintain the temperature of the extractor at 35 °C, keep the system stable, and reflux for 1 hour to obtain the supercritical extract of Curcuma curcuma curcuma with good fluidity and darker color.

Embodiment 3

[0050] Preparation of Curcuma curcuma supercritical extract:

[0051] Weigh 8kg of Curcuma curcuma, put it in the extractor, start the carbon dioxide high-pressure pump, and adjust the pressure of the extractor and the flow rate of carbon dioxide to maintain the optimized parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, that is, the extraction pressure is 22MPa, and the extraction flow rate is 1.8kg / m 2 ·s; According to the fluctuation of pressure and flow, adjust the temperature of the heating system, maintain the temperature of the extractor at 45°C, keep the system stable, and reflux for 1.5 hours to obtain the supercritical extract of Curcuma curcuma curcuma with good fluidity and darker color.

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Abstract

The invention discloses an externally-used Chinese transdermal preparation for treating skin cancer which mainly comprises supercritical extract of curcuma zedoaria rose, and can effectively inhibit skin cancer cells from proliferation with the advantages of precise curative effect, easiness in use, and non- toxicity and side actions.

Description

technical field [0001] The invention relates to a transdermal preparation for external use of a traditional Chinese medicine, in particular to a transdermal preparation for external use of a traditional Chinese medicine for treating skin cancer. Background technique [0002] Skin cancer refers to squamous cell carcinoma and basal cell carcinoma that occur in the skin, in addition to adnexal carcinomas such as sweat gland carcinoma, carcinoma in situ, and melanoma. Modern medicine believes that the cause of this disease is not clear, it may be related to skin diseases and physical and chemical stimuli such as ultraviolet rays, X-rays and other radiation. Most of them belong to the categories of "turning flowers", "stone boils" and "black boils" in the clinical practice of traditional Chinese medicine. They are nostalgic for the evil of wind toxin and dryness for a long time, causing dryness of liver blood and malignant sores on the skin. Treatment methods include surgical exc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/70A61K9/06A61P35/00A61M37/00
Inventor 沈平孃刘志远肖琼汤秀珍蓝闽波林志宏齐春华杜晨捷赵明张继全
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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