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Method and apparatus for evaluating interaction between protein complexes

A complex and protein technology, applied in proteomics, data processing applications, special data processing applications, etc., can solve problems such as the evaluation of the validity of the interaction properties of protein complexes

Inactive Publication Date: 2009-12-02
FUJITSU LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0018] However, in the conventional techniques described above, the validity evaluation of the interaction properties between protein complexes was not performed at the above two levels

Method used

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  • Method and apparatus for evaluating interaction between protein complexes
  • Method and apparatus for evaluating interaction between protein complexes
  • Method and apparatus for evaluating interaction between protein complexes

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Experimental program
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Embodiment Construction

[0064] A number of exemplary embodiments according to the present invention will be described in detail below with reference to the accompanying drawings in the following sections 1 to 4:

[0065] 1. General overview of interaction assessment equipment ( figure 1 and 2 );

[0066] 2. The subunit forming unit of the interaction assessment device (Figures 3 to 10);

[0067] 3. The learning unit in the interaction assessment device ( Figures 11 to 23 );as well as

[0068] 4. The prediction target generation unit and execution unit in the interaction evaluation device ( Figures 24 to 32 ).

[0069]

[0070] Regarding the overall overview of the interaction evaluation device, the hardware configuration, functional configuration, etc. of the interaction evaluation device will be described below.

[0071] figure 1 is a block diagram showing a hardware configuration of an interaction evaluation device according to an embodiment of the present invention.

[0072] Such as ...

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Abstract

In an interaction evaluating apparatus, a sub-unit forming unit uses complex pair information as input information and refers to a family DB to make sub-units of the complex pair information. A GODB is a database that stores information relating to the protein attributes. A learning unit uses sub-unit complex pair information as input information and refers to the GODB to output a prediction rule set. An executing unit uses prediction target data obtained from a prediction-target generating unit as input information and refers to the prediction rule set to calculate an execution result, i.e., an attribute score that is validation evaluation of an interaction attribute of a sub-unit pair.

Description

technical field [0001] The present invention relates to techniques for assessing the validity of the interaction properties of protein complexes. Background technique [0002] In order to understand molecular biological mechanisms in organisms, it is beneficial to understand the interaction properties (such as direction and type of activation, phosphorylation, inhibition, etc.) of interactions between protein complexes. [0003] On the other hand, where protein complex interactions are predicted by trial and error techniques, usually only the existence of the interaction is predicted. Although interaction properties can be extracted by using natural language processing in conjunction with the literature, the results contain noise. At present, data concerning the interaction between protein complexes include KEGG (Kyoto Encyclopedia of Genes and Genomes, [online] [retrieved on February 27, 2006), Internet <URL: http: / / www.genome.jp / keg / pathway.html>]), etc. [0004]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/00G06F17/30G01N33/50G16B20/00G01N33/48G01N33/53G01N33/566G06Q10/04G16B20/20G16B20/30
CPCG06F19/18G06F19/24G16B20/00G16B40/00G16B20/30G16B20/20
Inventor 山川宏丸桥弘治仲尾由雄
Owner FUJITSU LTD