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Collunarium containing vitamin B12

A vitamin and B12 technology, which can be used in blood diseases, extracellular fluid diseases, medical preparations with inactive ingredients, etc., and can solve the problems of low absorption rate and poor stability.

Active Publication Date: 2007-08-08
ZHEJIANG ASEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Vitamin B available 12 The preparation for intranasal administration has a certain degree of irritation, and the stability is poor and the absorption rate is not high. After exploring, the present invention has found a non-irritating preparation composition, which overcomes the defects of the prior art

Method used

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  • Collunarium containing vitamin B12

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] Vitamin B 12 25g

[0162] Methylcellulose 50g

[0163] Glycerin 50g

[0164] Benzalkonium bromide solution (5%) 10ml

[0165] *Citrate buffer solution to 2300ml

[0166] Wherein the preparation of citrate buffer solution is as follows (100ml):

[0167] Citric acid 0.52g

[0168] Sodium citrate 1.58g

[0169] Add water for injection to 100ml

[0170] preparation:

[0171] (1). Prepare citrate buffer:

[0172] Weigh 26g of citric acid and 79g of sodium citrate, add water for injection to dissolve and dilute to 2300ml, measure the pH value at 4.5-5.5, filter and sterilize with a 0.22μm microporous membrane, and set aside.

[0173] (2). Prepare 2.0% methylcellulose liquid:

[0174] Weigh 50g of methyl cellulose, add 2500ml of citrate buffer solution, add 50g of glycerin, stir well, sterilize by circulating steam at 100°C for 30 minutes, put in the refrigerator overnight (to redissolve), and set aside.

[0175] (3). Preparation of vitamin B12 nasal...

Embodiment 2

[0179] Vitamin B 12 11.5g

[0180] Methylcellulose 25g

[0181] Glycerin 25g

[0182] Benzalkonium bromide solution (5%) 5ml

[0183] *Citrate buffer solution to 2300ml

[0184] Wherein the preparation of citrate buffer solution is as follows (100ml):

[0185] Citric acid 0.52g

[0186] Sodium citrate 1.58g

[0187] Add water for injection to 100ml

[0188] The preparation method is the same as in Example 1.

Embodiment 3

[0190] Vitamin B 12 50g

[0191] Methylcellulose 100g

[0192] Glycerin 100g

[0193] Benzalkonium bromide solution (5%) 20ml

[0194]*Citrate buffer solution to 2300ml

[0195] Wherein the preparation of citrate buffer solution is as follows (100ml):

[0196] Citric acid 0.52g

[0197] Sodium citrate 1.58g

[0198] Add water for injection to 100ml

[0199] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a vitamin B12 collunarium liquid preparation, which is prepared from vitamin B12, adhesion promoter, pH modifier, osmoregulation agent and preservative agent.

Description

Technical field: [0001] The present invention relates to a pharmaceutical preparation, in particular to a preparation containing vitamin B 12 nasal drops pharmaceutical preparations. Background technique: [0002] Vitamin B 12 English name: Vitamin B 12 Chemical name: Cyanocobalamin [0003] The chemical structural formula is as follows: [0004] [0005] Vitamin B 12 It is an essential vitamin for cell growth and reproduction, hematopoiesis, synthesis of nucleic acid and nerve myelin lipids, and maintenance of the functional integrity of sheathed nerve fibers. Vitamin B 12 Participate in methyl conversion and folic acid metabolism in the body, promote the conversion of 5-methyltetrahydrofolate into tetrahydrofolate, and act as vitamin B 12 When it is lacking, it can lead to folic acid deficiency and DNA synthesis disorder, affecting the maturation of red blood cells. Since this product can promote the transformation of methylmalonic acid into succinic acid and pa...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61K47/32A61K47/16A61K47/10A61K47/12A61K47/34A61K47/38A61P7/06A61P25/00
Inventor 邓金明吴海英
Owner ZHEJIANG ASEN PHARMA
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