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Compound nicotinamide medicine for antiphlogosis, wet storage and eliminating spot

A technology of nicotinamide and composition, applied in the field of compound nicotinamide medicinal composition, can solve problems such as unsatisfactory treatment effect and the like

Inactive Publication Date: 2007-08-22
HOSPITAL OF DERMATOLOGY CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, many diseases of the skin, such as eczema and dry skin diseases, are closely related to the loss of the integrity of the lipid barrier function of the stratum corneum. In addition, other causes cause a variety of acute and chronic syndromes, so the therapeutic effect of a single drug is often not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1, the compound niacinamide pharmaceutical composition for anti-inflammation, moisturizing and moisturizing, and reducing pigmentation, the mass percentage of each component is: 2% niacinamide and 0.05% all-trans retinoic acid. The rest are auxiliary materials and made into cream.

Embodiment 2

[0026] Example 2 is basically the same as Example 1, but the nicotinamide is 4%, and the retinoic acid is cis-retinoic acid 0.025%. The rest are auxiliary materials and made into ointment.

Embodiment 3

[0027] Example 3 is basically the same as Example 1, but the nicotinamide is 10%, and the retinoic acid is all-trans retinoic acid and cis retinoic acid 0.035%. The rest are auxiliary materials and made into gel.

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PUM

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Abstract

The compound nicotinamide medicine for antiphlogosis, wet storage and eliminating spot consists of nicotinamide 2-10 wt%, trans- or cis-vitamin A acid 0.025-0.05 wt%, and corticosteroid 0.025-1 wt%. It has functions of moistening skin, diminishing inflammation, inhibiting melanogenesis, and treating eczema, skin pruritus, acne, etc.

Description

technical field [0001] The invention relates to a compound skin external pharmaceutical composition of niacinamide, in particular to a compound niacinamide pharmaceutical composition with the characteristics of anti-inflammation, moisturizing and moisturizing, reducing skin pigmentation and anti-aging skin. Background technique [0002] Nicotinamide is an antioxidant that can effectively prevent cells and cell membranes from free radical damage, and can eliminate superoxide anion free radicals that play a role in inflammation; it also has anti-inflammatory activity, can inhibit phosphodiesterase and / or inhibit Mast cell degranulation can directly inhibit the release of histamine receptors and histamine, inhibit the chemotaxis of neutrophils, and inhibit the transformation of lymphocytes and the regulation of genes. [0003] It has been confirmed in keratinocyte culture that nicotinamide can increase the synthesis of ceramide, fatty acid and cholesterol, and has the effect of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/455A61K31/58A61K31/573A61K9/00A61K9/06A61P17/00A61P29/00A61K31/19
Inventor 申国庆
Owner HOSPITAL OF DERMATOLOGY CHINESE ACAD OF MEDICAL SCI