Black and white medicinal composition for improving sleep and adjusting sleep-rhythm functions

A technology for improving sleep and composition, which is applied in the field of black and white pharmaceutical compositions, can solve the problems of no breathing inhibition, practicability, curative effect, drug economy, and no interaction, so as to prevent platelet aggregation and prevent cardiovascular and cerebrovascular diseases. disease, curative effect

Inactive Publication Date: 2007-09-05
陈彦方
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] An ideal sedative-hypnotic drug should meet the following conditions: 1) quickly induce sleep; 2) have no effect on sleep structure; 3) have no drug residual effect the next day; 4) do not affect cognitive and memory functions; 5) have no inhibition on breathing 6) long-term use without drug dependence; 7) no interaction with alcohol and other drugs
However, so far, there is no sleeping drug that ful

Method used

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Examples

Experimental program
Comparison scheme
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Example Embodiment

[0042] In order to prepare a pharmaceutical composition and more specifically an administration unit, the present invention further includes a method comprising diphenhydramine and vitamin B 6 And a method for preparing two pharmaceutical compositions of aspirin and caffeine, the method comprising combining a certain amount of diphenhydramine (or a pharmaceutically acceptable salt thereof) and a certain amount of vitamin B 6 The step of mixing one or more pharmaceutical excipients to make a black preparation and the step of mixing a certain amount of aspirin and a certain amount of caffeine into one or more pharmaceutical excipients to make a white preparation.

[0043] Recently, it is more common to prescribe a pharmaceutical composition in the form of a "patient medication package" to a patient, which contains a certain number of administration units or a unit dose given in different treatment periods, usually a single package in a blister pack. Other utensils used. Patient medi...

Example Embodiment

[0070] Example 1: Verification of practicality

[0071] Because drugs are special commodities, they must be approved by the drug administration of various countries in accordance with the new drug review and registration management measures before they can be marketed. However, new drugs that cannot be approved cannot be marketed and are not practical. The drug administration laws of various countries all define new compound preparations as: the excipient composition of two or more active ingredients and inactive ingredients. In China and most countries in the world, 5-hydroxytryptophan and melatonin are active food additives rather than medicines. Any new compound drug in the formula that contains excipients that are neither the active ingredient nor the inactive ingredient of the drug violates the relevant regulations of the drug administration and cannot be approved for marketing. Drugs that have not been approved for marketing are defined as fake drugs.

[0072] The prescripti...

Example Embodiment

[0079] Example 2: Verification of drug economy

[0080] Governments of various countries define the attributes of drugs as: safe, effective, economical, stable and uniform. The so-called economy means that the price is cheap, and the price is composed of raw material costs, manufacturing costs, taxes, and profits. In general industrial products, raw material costs account for 35%-50% of the price.

[0081] Product name

[0082] Product name

[0083] Vitamin B6

[0084] The raw material cost (RMB / 1000 single dose) of the black and white pharmaceutical composition of the present invention is 44.2 RMB. The raw material cost (yuan / single dose) of the Chinese invention patent "A black and white pharmaceutical composition for treating insomnia" (Patent No. ZL 200510093405.5) is RMB 249.05, and the raw material cost is 5.63 times that of the present invention (249.05 / 44.2). Calculated on the basis that the cost of raw materials in general industrial products...

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PUM

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Abstract

A composite black-white medicine for improving sleep quality and regulating sleep rhythm is composed of a black component taken at night and containing diphenhydramine and VB6 and a white component taken in the day and containing aspirin and caffeine.

Description

technical field [0001] The invention relates to a black-and-white pharmaceutical composition, in particular to a pharmaceutical composition including diphenhydramine for improving sleep and adjusting sleep-wake rhythm. Background technique [0002] The most basic definition of insomnia refers to often not getting enough sleep, that is, lack of sleep, or sleep not deeply or well, generally showing three characteristics of initial insomnia, intermittent insomnia and terminal insomnia. Occasional insomnia doesn't matter much, and only those who can't sleep for a long time are considered to have insomnia. The incidence of insomnia is very high. According to foreign data surveys, the incidence of insomnia in the American population is 32%-35%, and Japan is 20%. There are also a large number of insomnia patients in China, especially the number of middle-aged and elderly people who suffer from insomnia. Foreign statistics show that the elderly suffer from insomnia as high as 70%....

Claims

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Application Information

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IPC IPC(8): A61K31/4415A61K31/616A61K31/522A61P25/20A61K31/138
Inventor 陈彦方汪光亮
Owner 陈彦方
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