Pharmacokinetic analyzing system and method

A pharmacokinetics, analysis and processing technology, applied in the field of pharmacokinetics analysis system, can solve the problems of difficult genetic polymorphism data, insufficient estimation accuracy, etc., and achieve the effect of improving estimation accuracy

Inactive Publication Date: 2007-10-10
HITACHI LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is difficult to obtain more individual polymorphism data in pharmacokinetic analysis, and there is a problem that the estimation accuracy of population haplotype frequencies and individual disomytypes is insufficient.

Method used

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  • Pharmacokinetic analyzing system and method
  • Pharmacokinetic analyzing system and method
  • Pharmacokinetic analyzing system and method

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Embodiment Construction

[0030] FIG. 1 is a schematic diagram showing an example of the device configuration of the pharmacokinetic analysis device of the present invention. The pharmacokinetic analysis device of the present invention is mainly composed of an electronic computer such as a so-called personal computer. The processing device 1 , memory 2 , input device 3 , display device 4 , and external storage device 10 are connected by a system bus 5 . The external storage device 10 stores the drug concentration data 11 of a plurality of individuals obtained from clinical trials, the gene data 12 of a plurality of individuals, the clinical data 13 of a plurality of individuals, and the pharmacokinetic data for the pharmacokinetic analysis of the present invention. Analysis handler 14. Of course, in addition to this, it is also equipped with databases and processing programs necessary for the functioning of electronic computers.

[0031] The pharmacokinetic analysis processing program 14 includes a p...

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Abstract

Systems and methods for analyzing pharmacokinetics in such a manner that the influence of genetic polymorphisms of an individual are taken into consideration, and for allowing implementation of high-accuracy haplotype frequency estimation and diplotype configuration estimation even in cases where the number of individuals is small from which data is obtainable when making pharmacokinetic analyses.

Description

technical field [0001] The present invention relates to a pharmacokinetic analysis system and method for analyzing individual blood drug concentration changes in consideration of the influence of gene polymorphisms. Background technique [0002] Drugs taken by people generally go through the so-called process of release, absorption, distribution, metabolism and excretion. The field of study that involves changes in drug concentration in body fluids (mainly in blood) during this process is called pharmacokinetics (Pharmacokinetics: PK). When studying human pharmacokinetics, it is based on statistical analysis of pharmacokinetic-related data such as blood drug concentration or urinary excretion obtained from clinical trials, and studies are conducted based on the results. [0003] When performing pharmacokinetic analysis on the blood drug concentration data obtained from clinical trials, the following two situations are generally considered: the situation of inferring the pha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B19/00A61B5/00G06F17/00G06F15/00G06Q50/00G16B20/20G01N33/15G06Q50/10G16B20/40G16B50/30G16H10/60
CPCG06F19/28G06F19/704G06F19/18G16B20/00G16B50/00G16C20/30G16B20/40G16B50/30G16B20/20
Inventor 斋藤聪谷川浩司吉川惠美子
Owner HITACHI LTD
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