Herba polygonic avicularis total flavones and its preparing method and medicine use

A technology for extract and total flavonoids, which is applied in the field of total flavonoid extract and its preparation, can solve the problems of unclear curative substances, inconvenient use, difficult quality control, etc. Effect

Inactive Publication Date: 2007-11-14
郭伟英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the decoction of traditional Chinese medicine, it is inconvenient to use, the curative substances are not clear, and the quality is not easy to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Adding the coarse powder of flat storage to water-containing ethanol and extracting 3-5 times by means of reflux or ultrasonic circulation, and the mass concentration of said water-containing ethanol is 50-95%. Wherein the weight ratio of flat storage and water-containing ethanol is 1:9~1:11, the solutions obtained from each extraction are combined, filtered, and after recovering ethanol, the extract is vacuum-dried to obtain extract powder, and then purified by an adsorption resin column , the aqueous solution of the extract powder is passed through the macroporous adsorption resin, then washed with water of 5-10 times the volume of the resin column, then eluted with 5-12 times the volume of the resin column, and the mass concentration is 30-40% ethanol, concentrated, and The concentrated solution is vacuum-dried to obtain a flavonoid extract. The sum of the weights of the flavonoids in the extract is 25% to 80% of the total weight of the extract. Dihydroflavonoids, di...

Embodiment 2

[0022] ultrasonic loop extraction

[0023] 1. Extraction

[0024] Take 200g of the original medicinal material of flat storage, pulverize it, and carry out ultrasonic circulation extraction for 3 times at 40°C with 2000mL of 65% ethanol at a power of 800W and a rotation speed of 1000r / min, each time for 35min. The solutions obtained from the various extracts were combined, filtered to remove the precipitate, the filtrate was concentrated under reduced pressure (55-65°C, 0.06-0.1Mpa), and then vacuum-dried to obtain the extract powder. Use purified water to configure an appropriate concentration according to the amount of resin to over-large porous adsorption resin D 101 Column, flow rate 1-2mL / min, then wash with 500-1000mL water, discard the wash, elute with 500-1000mL40% ethanol, elution rate 1-2mL / min, collect the eluate and concentrate under reduced pressure (60°C, 0.06-0.1Mpa) to nearly dry, and dried in a vacuum oven (60°C, 0.08-0.1Mpa, silica gel desiccant) for 3 hour...

Embodiment 3

[0031] Reflux extraction

[0032] Add the coarse powder of the lentils into ethanol with a mass concentration of 85% for reflux extraction for 3-5 times, wherein the weight ratio of the lentils to the water-containing ethanol is 1:9 to 1:11, combine the solutions obtained from each extraction, filter, and recover the ethanol Finally, vacuum-dry the extract to obtain extract powder, then use an adsorption resin column to carry out purification treatment, pass the aqueous solution of the extract powder through the macroporous adsorption resin, then wash with water 5-10 times the volume of the resin column, and then use 5-12 Times resin column volume, mass concentration is 30~40% ethanol eluting, concentrating, and concentrated solution is vacuum-dried, obtain flavonoid extract, the sum of the weight of flavonoid compound in the extract is 25%~of the total weight of extract 80%, the flavonoids refer to the chemical structure belonging to flavonoids, flavonols, dihydroflavonoids, ...

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Abstract

The present invention relates to a knotgrass total flavone extract, in which the weight of flavone compound is 25-80% of total weight of said extract. Its preparation method includes the following steps: firstly; adding knotgrass crude powder into aqueous ethyl alcohol for making extraction for 3-5 times, in which the weight rato of knotgrass crude powder and aqueous ethyl alcohol is 1:9-1:11, combining all the obtained solutions, filtering, recovering ethyl alcohol, vacuum-drying so as to obtain extract powder, making purification treatment so as to obtain the invented knotgrass flavone extract. Said knotgrass flavone extract can be used for preparing medicine for reducing blood sugar, and said medicine can be made into tablet preparation or capsule preparation.

Description

technical field [0001] The invention relates to an extract of total flavonoids from lentils, a preparation method thereof, and an application of the extract in hypoglycemic drugs. Background technique [0002] Flat storage (Polygonum aviculare L.) is also known as flat bamboo, bamboo grass, pig's tooth grass, etc. The source is the flat aboveground part of Polygonaceae plants, which are produced in most parts of the country. Biancu is a commonly used traditional Chinese medicine, which has the effects of diuresis, detoxification and antipruritic. For bladder hot stranguria, short red urine, stranguria pain, skin eczema, pruritus vaginal discharge. Plenum contains a variety of medicinal active ingredients, mainly including flavonoids principitin and quercetin. Among them, lentoside has antiviral, anti-inflammatory and diuretic and hypotensive effects; quercetin has antiviral effect and can be used as anti-inflammatory and diuretic. According to modern clinical medicine re...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/704A61P3/10C07D311/30C07H1/08
Inventor郭伟英袁春玲
Owner郭伟英